The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment: Discriminative Accuracy and Neural Correlates

Horta‐Barba, Andrea; Pagonabarraga, Javier; Martínez‐Horta, Saül; Marín‐Lahoz, Juan; Sampedro, Frederic; Fernández-Bobadilla, Ramón; Botí, Mariángeles; Bejr‐Kasem, Helena; Aracil‐Bolaños, Ignacio; Pérez‐Pérez, Jesús; Pascual-Sedano, Berta; Campolongo, Antònia; Izquierdo, Cristina; Gómez‐Anson, Beatriz; Kulisevsky, Jaime

doi:10.3389/fneur.2020.00240

Cited by 7 publications

(7 citation statements)

References 34 publications

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“…Recent meta-analyses and lesion-based studies have also shown that verbal fluency is supported by standard language networks and underlying white-matter connectivity (Griffis et al ., 2017; Costafreda et al ., 2006; Baldo et al ., 2006). Therefore, the ERP pattern associated with lower verbal fluency – suggestive of less efficient predictive processing mechanisms, as previously dicussed – may reflect not only executive dysfunction, but also disruption in semantic networks, in line with recent findings of difficulties in temporal-dependent functions in PD and PD-MCI (Horta-Barba et al ., 2020; Martínez-Horta et al ., 2019; Lang et al ., 2019).…”

Section: Discussionsupporting

confidence: 86%

Neural signatures of predictive language processing in parkinson’s disease with and without mild cognitive impairment

León-Cabrera

Pagonabarraga

Morís³

et al. 2020

Preprint

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Cognitive deficits are common in Parkinson’s disease (PD), with some PD patients meeting criteria for mild cognitive impairment (MCI). An unaddressed question is whether linguistic prediction is preserved in PD. This ability is nowadays deemed crucial in achieving fast and efficient comprehension, and it may be negatively impacted by cognitive deterioration. To fill this gap of knowledge, we used event-related potentials (ERPs) to evaluate mechanisms of linguistic prediction in a sample of PD patients (on dopamine compensation) with and without MCI. To this end, participants read sentence contexts that were predictive or not about a sentence-final word. The final word appeared after 1 second, matching or mismatching the prediction. The introduction of the interval allowed to capture neural responses both before and after sentence-final words, reflecting semantic anticipation and processing. PD patients with normal cognition (N = 58) showed ERP responses comparable to those of matched controls. Specifically, in predictive contexts, a slow negative potential developed prior to sentence-final words, reflecting semantic anticipation. Later, expected words elicited reduced N400 responses (compared to unexpected words), indicating facilitated semantic processing. Besides, PD patients with MCI (N = 20) showed a prolongation of the N400 congruency effect (compared to matched PD patients without MCI), indicating that further cognitive decline impacts semantic processing. Finally, lower verbal fluency scores correlated with prolonged N400 congruency effects and with reduced pre-word differences in all PD patients (N = 78). This relevantly points to a role of deficits in temporal-dependent mechanisms in PD, besides prototypical frontal dysfunction, in altered semantic anticipation and semantic processing during sentence comprehension.

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Section: Discussionsupporting

confidence: 86%

Neural signatures of predictive language processing in parkinson’s disease with and without mild cognitive impairment

León-Cabrera

Pagonabarraga

Morís³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recent meta-analyses and lesion-based studies have also shown that verbal fluency is supported by standard language networks and underlying whitematter connectivity (Griffis et al, 2017;Costafreda et al, 2006;Baldo et al, 2006). Therefore, the ERP pattern associated with lower verbal fluencysuggestive of less efficient predictive processing mechanisms, as previously dicussedmay reflect not only executive dysfunction, but also disruption in semantic networks, in line with recent findings of difficulties in temporaldependent functions in PD and PD-MCI (Horta-Barba et al, 2020;Martínez-Horta et al, 2019;Lang et al, 2019).…”

Section: Pd-mci Impacts Late Semantic Processing In Predictive Contextssupporting

confidence: 76%

“…Furthermore, both executive dysfunction and damage within semantic networks may underlie these difficulties, as suggested by their association with low verbal fluency scores. Along with recent research (Horta-Barba et al, 2020;Martínez-Horta et al, 2019;Lang et al, 2019), these findings emphasize the value of examining cognitive changes in PD and PD-MCI in domains beyond executive functions, like the language domain. Interestingly, altered N400 effects are associated with a higher risk of transiting to dementia in individuals with amnesic MCI (Olichney et al, 2008).…”

Section: Concluding Remarks and Future Directionsmentioning

confidence: 57%

“…Crucially, up to 40% of individuals with PD will develop mild cognitive impairment (PD-MCI) within the first 5 years of disease (Aarsland et al, 2010;Litvan et al, 2011), which is a robust predictor of further conversion to dementia (PDD). Among the several cognitive phenotypes characterizing PD-MCI, changes in visuoperceptive skills, memory or language have been highlighted to be good predictors of the conversion from PD-MCI to PDD (Horta-Barba et al, 2020;Martínez-Horta et al, 2019;Lang et al, 2019). Based on this, we hypothesized that deficits in predictive language processing might contribute to sentence comprehension difficulties in PD and in PD-MCI.…”

Section: Introductionmentioning

confidence: 92%

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Neural signatures of predictive language processing in Parkinson's disease with and without mild cognitive impairment

León-Cabrera

Pagonabarraga

Morís

et al. 2021

Cortex

Self Cite

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Cognitive deficits are common in Parkinson's disease (PD), with some PD patients meeting criteria for mild cognitive impairment (MCI). An unaddressed question is whether linguistic prediction is preserved in PD. This ability is nowadays deemed crucial in achieving fast and efficient comprehension, and it may be negatively impacted by cognitive deterioration. To fill this gap of knowledge, we used event-related potentials (ERPs) to evaluate mechanisms of linguistic prediction in a sample of PD patients (on dopamine compensation) with and without MCI. To this end, participants read sentence contexts that were predictive or not about a sentence-final word.The final word appeared after 1 second, matching or mismatching the prediction. The introduction of the interval allowed to capture neural responses both before and after sentence-final words, reflecting semantic anticipation and processing. PD patients with normal cognition (N = 58) showed ERP responses comparable to those of matched controls. Specifically, in predictive contexts, a slow negative potential developed prior to sentence-final words, reflecting semantic anticipation. Later, expected words elicited reduced N400 responses (compared to unexpected words), indicating facilitated semantic processing. Besides, PD patients with MCI (N = 20) showed a prolongation of the N400 congruency effect (compared to matched PD patients without MCI), indicating that further cognitive decline impacts semantic processing. Finally, lower verbal fluency scores correlated with prolonged N400 congruency effects and with reduced pre-word differences in all PD patients (N = 78). This relevantly points to a role of deficits in temporal-dependent mechanisms in PD, besides prototypical frontal dysfunction, in altered semantic anticipation and semantic processing during sentence comprehension.

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“…Table 2 summarizes the seven studies which employed dMRI to explore neural correlates of memory in PD (Carlesimo et al., 2012; Chung et al., 2019; Gargouri et al., 2019; Horta‐Barba et al., 2020; Wang et al., 2020; Yao et al., 2016; Zheng et al., 2014). Three of these studies did not reveal any significant relationship between measures of verbal or visual episodic memory and diffusion characteristics of the hippocampus (Chung et al., 2019; Wang et al., 2020; Yao et al., 2016).…”

Section: Discussionmentioning

confidence: 99%

Hippocampal correlates of episodic memory in Parkinson’s disease: A systematic review of magnetic resonance imaging studies

Pourzinal,

Yang,

Bakker

et al. 2021

J of Neuroscience Research

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The present review asks whether magnetic resonance imaging (MRI) studies are able to define neural correlates of episodic memory within the hippocampus in Parkinson's disease (PD). Systematic searches were performed in PubMed, Web of Science, Medline, CINAHL, and EMBASE using search terms related to structural and functional MRI (fMRI), the hippocampus, episodic memory, and PD. Risk of bias was assessed for each study using the Newtown–Ottawa Scale. Thirty‐nine studies met inclusion criteria; eight fMRI, seven diffusion MRI (dMRI), and 24 structural MRI (14 exploring whole hippocampus and 10 exploring hippocampal subfields). Critical analysis of the literature revealed mixed evidence from functional and dMRI, but stronger evidence from sMRI of the hippocampus as a biomarker for episodic memory impairment in PD. Hippocampal subfield studies most often implicated CA1, CA3/4, and subiculum volume in episodic memory and cognitive decline in PD. Despite differences in imaging methodology, study design, and sample characteristics, MRI studies have helped elucidate an important neural correlate of episodic memory impairment in PD with both clinical and theoretical implications. Natural progression of this work encourages future research on hippocampal subfield function as a potential biomarker of, or therapeutic target for, episodic memory dysfunction in PD.

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The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment: Discriminative Accuracy and Neural Correlates

Cited by 7 publications

References 34 publications

Neural signatures of predictive language processing in parkinson’s disease with and without mild cognitive impairment

Neural signatures of predictive language processing in parkinson’s disease with and without mild cognitive impairment

Neural signatures of predictive language processing in Parkinson's disease with and without mild cognitive impairment

Hippocampal correlates of episodic memory in Parkinson’s disease: A systematic review of magnetic resonance imaging studies

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