The frail elderly: role of dendritic cells in the susceptibility of infection

Uyemura, Koichi; Castle, Steven; Makinodan, Takashi

doi:10.1016/s0047-6374(02)00033-7

Cited by 108 publications

(74 citation statements)

References 38 publications

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“…The immune response in the 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 3 frail elderly however, differs to that of the healthy elderly (Jing et al, 2009). Of note, the proportion of elderly within the general population who fulfil strict inclusion criteria of the SENIEUR protocol is low; only 10-15% (Uyemura et al, 2002) meaning that the results from studies using the SENIEUR protocol for subject recruitment may not be representative of the majority of elderly people within the general population.…”

Section: Immunosenescence and Inflammagingmentioning

confidence: 99%

“…DCs are capable of activating naïve T cells (Uyemura et al, 2002). They capture antigens via various mechanisms including micropinocytosis, phagocytosis of pathogenic material, internalisation of heat shock proteins via receptors and by receptor-mediated endocytosis using the pattern recognition receptors (PRRs) C-type lectins and Fcγ receptors (Agrawal et al, 2007b).…”

Section: Apc In Aging: Dcsmentioning

confidence: 99%

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Nutrition, diet and immunosenescence

Maijó

Clements

Ivory

et al. 2014

Mechanisms of Ageing and Development

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Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly. We would like to thank the reviewers for their careful review of our manuscript, which has been revised accordingly. Below, we have provided a point-by-point reply to the issues raised: AbstractAgeing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly.

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Section: Immunosenescence and Inflammagingmentioning

confidence: 99%

Section: Apc In Aging: Dcsmentioning

confidence: 99%

Nutrition, diet and immunosenescence

Maijó

Clements

Ivory

et al. 2014

Mechanisms of Ageing and Development

View full text Add to dashboard Cite

show abstract

“…1). Moreover, aging is associated with a reduction in the number of DC derived from myeloid precursors (18), which also have a more mature phenotype and an impaired ability to produce IL-12 with age (17,108). Other functions such as macropinocytosis, endocytosis, response to chemokines, and cytokine secretion are impaired, probably as a consequence of decreased activation of the phosphoinositide-3 kinase pathway (2).…”

Section: Dendritic Cellsmentioning

confidence: 99%

Aging of the Immune System as a Prognostic Factor for Human Longevity

et al. 2008

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“…Several recent reviews have addressed the impact of aging on aspects of the adaptive immune system (Chakravarti & Abraham, 1999;Aspinall, 2003;Effros et al ., 2003;McGlauchlen & Vogel, 2003;Schroder & Rink, 2003;Linton & Dorshkind, 2004), dendritic cells (Uyemura et al ., 2002), and the effects of aging on genomic and proteomic aspects of macrophage function . This review focuses on the impact of aging on macrophage function in innate immunity.…”

Section: Introductionmentioning

confidence: 99%

Innate immunity in aging: impact on macrophage function

et al. 2004

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SummaryInnate and adaptive immune functions decline with age, leading to increased susceptibility to infectious diseases and cancer, and reduced responses to preventive vaccination in the elderly population. Macrophages function as 'pathogen sensors' and play an important role in the initiation of inflammatory responses, elimination of pathogens, manipulation of the adaptive immune response and reparation of damaged tissue. In this paper, we review the literature addressing the impact of aging on the macrophage population.

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The frail elderly: role of dendritic cells in the susceptibility of infection

Cited by 108 publications

References 38 publications

Nutrition, diet and immunosenescence

Nutrition, diet and immunosenescence

Aging of the Immune System as a Prognostic Factor for Human Longevity

Innate immunity in aging: impact on macrophage function

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