Abstract:Background
Genes involved in lung development may become dysregulated in adult life and contribute to the pathogenesis of lung diseases. Multiple genes regulate lung development, including Forkhead box protein P1-4 (FoxP1-4).
Methods
We examined the association between variants in the FoxP1-4 genes and lung function using data from a GWAS that included close to 400,000 individuals and 20 million SNPs.
Results
More than 100 variants in the FoxP1 gene, but none in the FoxP2-4 genes, are associated with lung f… Show more
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