The foveal photoreceptor layer and visual acuity loss in central serous chorioretinopathy

Piccolino, Felice Cardillo; Longrais, R. Rigault de la; Ravera, Giambattista; Eandi, Chiara M.; Ventre, Luca; Abdollahi, Ali; Manea, Marilisa

doi:10.1016/j.ajo.2004.08.037

Cited by 283 publications

(204 citation statements)

References 25 publications

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“…8 Distortion, shortening, or absence of IS/OS may indicate pathologic changes in photoreceptors as shown in RP 16 as well as in macular hole, 20 retinal detachment, 14 retinal vein occlusion, 21 central serous chorioretinopathy, 13,15,22 or multiple evanescent white dot syndrome. 23 Also in our patients, complete disappearance of IS/OS detected by OCT was correlated with decrease in VA, as expected.…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomographic pattern and focal electroretinogram in patients with retinitis pigmentosa

Oishi

Nakamura

Tatsumi

et al. 2008

Eye

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Section: Discussionmentioning

confidence: 99%

Optical coherence tomographic pattern and focal electroretinogram in patients with retinitis pigmentosa

Oishi

Nakamura

Tatsumi

et al. 2008

Eye

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“…[7][8][9] CSC has a high spontaneous remission rate, but there is evidence of the benefit of early treatment. [10][11][12] CSC with single, extrafoveal leaking point can be treated using focal photocoagulation to shorten the duration of symptoms without altering the final visual outcomes and the recurrent rate. [13][14][15] This method, however, has a significant adverse effect such as symptomatic scotomas, secondary choroidal neovascularization (CNV), and so on.…”

Section: Introductionmentioning

confidence: 99%

“…However, these findings should be interpreted cautiously because of the self-limiting characteristics of CSC, which can show spontaneous improvement within months. 1,2,12,[22][23][24][25] Therefore, we performed a meta-analysis of the efficacy of IVB in terms of visual acuity and macular thickness to gain a better perspective regarding the therapeutic options in CSC.…”

Section: Introductionmentioning

confidence: 99%

Lack of positive effect of intravitreal bevacizumab in central serous chorioretinopathy: meta-analysis and review

Younghae

et al. 2013

Eye

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Purpose To review and evaluate the effects of intravitreal bevacizumab injection (IVB) in centralserous chorioretinopathy (CSC) by meta-analysis. Patients and methods Clinical controlled studies that evaluated the effect of IVB in CSC were identified through systematic searches of Embase, PubMed, and the Cochrane Central Register of Controlled Trials. Data on the bestcorrected visual acuity (BCVA) in logMAR and central macular thickness (CMT) in mm at baseline and 6 months after IVB were extracted and compared with those treated by simple observation.Results Four clinical controlled studies were included in the meta-analysis. The IVB injection group achieved better BCVA at a follow-up of 6 months. However, the analysis showed that there were no significant differences of BCVA at 6 months after injection between IVB group and the observation group ( À 0.02 logMAR, 95% CI À 0.14 to 0.11, P ¼ 0.80). The analysis of the reduction in CMT revealed that the difference between groups was not statistically significant ( À 8.37 lm, 95% CI À 97.26 to 80.52, P ¼ 0.85). No report assessed severe complications or side effects of IVB in patients with CSC. Conclusions Meta-analysis failed to verify the positive effect of IVB in CSC based on the epidemiological literature published to date.

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“…This third high reflectance band is depicted as the outer boundary of the retina, and it has been suggested that it represents the photoreceptor inner segment/outer segment junction (IS/OS). 17 As OCT can observe the status of IS/OS, it has been used to study various aetiologies, including those of central serous chorioretinopathy, [18][19][20] retinal vein occlusion, [21][22][23] macular hole, 24 retinal detachment, 25 and multiple evanescent white dot syndrome. 26 All of the reports have consistently shown that the status of IS/OS is closely correlated with the visual function and/or the pathological change.…”

Section: Introductionmentioning

confidence: 99%

Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa

Oishi

Otani

Sasahara

et al. 2008

Eye

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Aims To assess the correlation between macular morphology and visual acuity in retinitis pigmentosa (RP) patients with cystoid macular oedema (CME). Design Retrospective cross-sectional study. Patients and methods Forty-one eyes of 25 RP patients with CME. Patients underwent cross-sectional scans with optical coherence tomography (Stratus OCT). Age, total retinal thickness, photoreceptor thickness, and the transverse and vertical lengths of the cystoid space were measured. Correlation between visual acuity and each of the measurements were examined. Additionally, the status of the inner segment/outer segment junction (IS/OS) was classified as being absent, discontinuous, or distinct. Measurements were then compared among the three groups. Results Total retinal thickness or photoreceptor thickness was not correlated with visual acuity. There was a correlation between the transverse length of the cystoid space and visual acuity, although the correlation coefficient was weak (r ¼ 0.30). The logMAR visual acuity in the IS/OS absent group (0.67±0.43) was worse than that seen in the IS/OS discontinuous (0.22 ± 0.19) or IS/OS distinct groups (0.07 ± 0.16) (Po0.001). Conclusions When monitoring CME associated with RP, the status of IS/OS is the essential parameter that needs to be examined.

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The foveal photoreceptor layer and visual acuity loss in central serous chorioretinopathy

Cited by 283 publications

References 25 publications

Optical coherence tomographic pattern and focal electroretinogram in patients with retinitis pigmentosa

Optical coherence tomographic pattern and focal electroretinogram in patients with retinitis pigmentosa

Lack of positive effect of intravitreal bevacizumab in central serous chorioretinopathy: meta-analysis and review

Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa

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