The Fortunate Professor

The history of , the causative agent of bacillary dysentery, is a long and fascinating one. This brief historical account starts with descriptions of the disease and its impact on human health from ancient time to the present. Our story of the bacterium starts just before the identification of the dysentery bacillus by Kiyoshi Shiga in 1898 and follows the scientific discoveries and principal scientists who contributed to the elucidation of pathogenesis in the first 100 years. Over the past century, has proved to be an outstanding model of an invasive bacterial pathogen and has served as a paradigm for the study of other bacterialpathogens. In addition to invasion of epithelial cells, some of those shared virulence traits include toxin production, multiple-antibiotic resistance, virulence genes encoded on plasmids and bacteriophages, global regulation of virulence genes, pathogenicity islands, intracellular motility, remodeling of host cytoskeleton, inflammation/polymorphonuclear leukocyte signaling, apoptosis induction/inhibition, and "black holes" and antivirulence genes. While there is still much to learn from studying pathogenesis, what we have learned so far has also contributed greatly to our broader understanding of bacterial pathogenesis.

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“…In 1961, Stanley Falkow (Fig. 4) also received his Ph.D. in Biology from Brown University under the direction of Doc Stuart (167,168).…”

Section: Acknowledgmentsmentioning

confidence: 99%