The Formidable yet Unresolved Interplay between Endometriosis and Obesity

Pantelis, Athanasios; Machairiotis, Nikolaos; Lapatsanis, Dimitris P.

doi:10.1155/2021/6653677

Cited by 24 publications

(24 citation statements)

References 68 publications

(93 reference statements)

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“…To date, there is convincing evidence for an inverse association of endometriosis and BMI [ 231 ]. Low overall adiposity and a preferred localization of fat below the waist were found to be related to endometriosis [ 232 ].…”

Section: Endometriosismentioning

confidence: 99%

“…In later life, abdominal fat distribution contributes to the development of endometriosis [ 233 ]. Overweight/obesity is a risk factor for various diseases, and obesity as well as endometriosis are associated with low-grade inflammation and higher estrogens, and thus an inverse relation is exceptional [ 231 ]. Associations of endometriosis with body-fat distribution and metabolic diseases, such as insulin resistance, have not been resolved.…”

Section: Endometriosismentioning

confidence: 99%

See 1 more Smart Citation

The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis

Schüler-Toprak¹,

Ortmann²,

Buechler³

et al. 2022

Biomedicines

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Polycystic ovary syndrome (PCOS) and endometriosis are frequent diseases of the female reproductive tract causing high morbidity as they can significantly affect fertility and quality of life. Adipokines are pleiotropic signaling molecules secreted by white or brown adipose tissues with a central role in energy metabolism. More recently, their involvement in PCOS and endometriosis has been demonstrated. In this review article, we provide an update on the role of adipokines in both diseases and summarize previous findings. We also address the results of multi-omics approaches in adipokine research to examine the role of single nucleotide polymorphisms (SNPs) in genes coding for adipokines and their receptors, the secretome of adipocytes and to identify epigenetic alterations of adipokine genes that might be conferred from mother to child. Finally, we address novel data on the role of brown adipose tissue (BAT), which seems to have notable effects on PCOS. For this review, original research articles on adipokine actions in PCOS and endometriosis are considered, which are listed in the PubMed database.

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Section: Endometriosismentioning

confidence: 99%

Section: Endometriosismentioning

confidence: 99%

The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis

Schüler-Toprak¹,

Ortmann²,

Buechler³

et al. 2022

Biomedicines

View full text Add to dashboard Cite

show abstract

“…Dziunycz et al obtained opposite results [ 10 ]. Based on the data on increased leptin and ghrelin levels in the PF, Pantelis et al suggested that endometriosis is associated with obesity, despite an obvious decrease in BMI in patients with endometriosis [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

The Levels of Ghrelin, Glucagon, Visfatin and Glp-1 Are Decreased in the Peritoneal Fluid of Women with Endometriosis along with the Increased Expression of the CD10 Protease by the Macrophages

Krasnyi

Sadekova

Smolnova

et al. 2022

IJMS

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The aim of this study was to evaluate the levels of ten energy metabolism factors: C-peptide, ghrelin, GIP, GLP-1, glucagon, insulin, leptin, PAI-1 (total), resistin, and visfatin, and to determine the expression of GLP1R receptors, CD10, CD26 proteases, and pro-inflammatory marker CD86 by macrophages in the peritoneal fluid (PF) in patients with endometriosis. The study included 54 women with endometriosis and a control group of 30 women with uterine myoma without signs of endometriosis. The levels of factors in PF were assessed by a multiplex method. Expression of GLP1R receptors, CD10, CD26 proteases, and CD86 by macrophages was evaluated using flow cytometry. It was found that in women with endometriosis, the concentrations of ghrelin, GLP-1, glucagon, and visfatin in PF were reduced (p = 0.007, p = 0.009, p = 0.002, p = 0.008, respectively). At the same time, there was a noted increase in the CD10 protease expression by peritoneal macrophages (p = 0.044). Correlation analysis showed a positive correlation of ghrelin and GLP-1 levels with CD86 macrophage expression (p = 0.044, p = 0.022, respectively) in the study group; a positive correlation was also found between the levels of GLP-1, glucagon, and visfatin with CD26 macrophage expression (p = 0.041, p = 0.048, p = 0.015, respectively) in PF. No correlations were found in the control group. These results indicate that a decrease in the levels of ghrelin, GLP-1, glucagon, and visfatin in PF may contribute to endometriosis development through their impact on the expression of pro-inflammatory markers of PF macrophages.

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“…Recent evidence highlights the multiple links between endometriosis and systemic diseases with immunologic and metabolic changes and has identified comorbidities associated with endometriosis such as autoimmune diseases, cancers, and cardiovascular disease [ 54 , 55 ]. Therefore, studies targeting biological substances that specifically function in both adipose tissue metabolism and endometriosis could help better understand the observed relationship between adiposity and the establishment or behavior of endometriosis [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical studies on body mass index (BMI) and endometriosis have demonstrated mixed results. There is evidence of an inverse correlation between endometriosis and BMI, and obesity is often associated with a lower incidence of endometriosis [ 23 , 24 , 25 , 26 ]. In a meta-analysis of studies on BMI and endometriosis from 2019, lower BMI increases the relative risk of endometriosis.…”

Section: Introductionmentioning

confidence: 99%

Leptin Stimulates Endometriosis Development in Mouse Models

et al. 2022

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Endometriosis is a chronic inflammatory condition in women, and obesity leads to an inflammatory condition that is directly involved in the etiology of endometriosis. However, observational studies have shown an inverse correlation between endometriosis and a low body mass index (BMI). Obesity does not protect against endometriosis, and on the contrary, an increased BMI may lead to more severe forms of the disease. To determine the effect of obesity on endometriosis, diet-induced and genetically engineered obese mouse models were integrated with endometriosis mouse models with fluorescence-tagged ectopic lesions. High-fat diet-induced obese mice revealed a significant increase in endometriosis development compared with regular-diet control mice. However, obese recipient mice with leptin deficiency and leptin receptor deficiency showed suppressed endometriosis development compared with control mice. Furthermore, donor uterine tissues with leptin deficiency and leptin receptor deficiency suppressed endometriosis development compared with control donor in control recipient mice. Importantly, we revealed that aberrant high levels of leptin concentration significantly increased endometriosis development compared with vehicle treatment group in control mice with normal body weight. Our results suggest that leptin and its receptor are critical for endometriosis development.

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The Formidable yet Unresolved Interplay between Endometriosis and Obesity

Cited by 24 publications

References 68 publications

The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis

The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis

The Levels of Ghrelin, Glucagon, Visfatin and Glp-1 Are Decreased in the Peritoneal Fluid of Women with Endometriosis along with the Increased Expression of the CD10 Protease by the Macrophages

Leptin Stimulates Endometriosis Development in Mouse Models

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