The Formation of the C  F Bond: The Last Twelve Years

Abstract

Introduction Nucleophilic Fluorinating Reagents Electrophilic Fluorinating Reagents Synthesis of Compounds Containing The 18 F Isotope For Use In Positron‐Emitting Tomography Recent Reviews on Selective Fluorination Methods

Fluorinated Isatin Derivatives. Part 2. New N-Substituted 5-Pyrrolidinylsulfonyl Isatins as Potential Tools for Molecular Imaging of Caspases in Apoptosis

“…Halofluorination of unsaturated compounds is a versatile method to introduce fluorine and, in addition, a second reactive function into organic compounds. − One of the most common procedures for bromofluorination uses N -bromosuccinimide (NBS) as the source of the bromonium ion and different amine−HF complexes. , A detailed account of regioselectivity of bromofluorination of functionalized olefins was provided by our research group a few years ago . Furthermore, Katzenellenbogen et al have previously demonstrated that bromofluorination could also serve as a radiochemical tool for introducing fluorine-18 into medicinally relevant compounds and thereby facilitate their use as imaging agents for PET. − …”

“…Halofluorination of unsaturated compounds is a versatile method to introduce fluorine and, in addition, a second reactive function into organic compounds. [41][42][43][44][45][46] One of the most common procedures for bromofluorination uses N-bromosuccinimide (NBS) as the source of the bromonium ion and different amine-HF complexes. 46,47 A detailed account of regioselectivity of bromofluorination of functionalized olefins was provided by our research group a few years ago.…”