The Formation of a Homologue of Cystine by the Decomposition of Methionine With Sulfuric Acid

Butz, Lewis W.; Vigneaud, Vincent du

doi:10.1016/s0021-9258(18)76074-2

Cited by 124 publications

(23 citation statements)

References 6 publications

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“…Homocysteine was discovered in 1932 by Butz and du Vigneaud (7). In the early 1960s, several independent groups reported the presence of homocystinuria in children with congenital anomalies and mental retardation (8,9).…”

Section: Early History Of Homocysteinementioning

confidence: 99%

Assessing Plasma Total Homocysteine in Patients with End-Stage Renal Disease

Urquhart

House

2007

Perit Dial Int

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Elevated plasma total homocysteine (tHcy) is a risk factor for cardiovascular disease; however, in light of several recent randomized trials, the issue of causality has been cast into doubt. Patients with end-stage renal disease are particularly interesting as they consistently have elevated tHcy and their leading causes of morbidity and mortality are related to cardiovascular disease. In the present article, we review the early evidence for the homocysteine theory of atherosclerosis, homocysteine metabolism, mechanisms of toxicity, and pertinent available clinical investigations. Where appropriate, the sparse evidence of homocysteine in peritoneal dialysis is reviewed. We conclude by addressing the difficulties associated with lowering plasma tHcy in patients with end-stage renal disease and suggest some novel methods for lowering tHcy in this resistant population. Finally, to address the issue of causality, we recommend that clinicians and scientists await the results of the FAVORIT trial before abandoning homocysteine as a modifiable risk factor for cardiovascular disease, as this study has recruited patients from a population with consistently elevated plasma tHcy who are known to respond to vitamin therapy.

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Section: Early History Of Homocysteinementioning

confidence: 99%

Assessing Plasma Total Homocysteine in Patients with End-Stage Renal Disease

Urquhart

House

2007

Perit Dial Int

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Section: Introductionmentioning

confidence: 99%

“…Homocysteine has been under a lot of speculation since its discovery in 1932 9 . It is known that a high plasma level of homocysteine significantly increases the incidence of vascular damage in both small and large vessels 9,10 . Hyperhomocysteinemia has neurotoxic, neuroinflammatory, neurodegenerative, proatherogenic, prothrombotic, and prooxidative effects 11 .…”

Section: Introductionmentioning

confidence: 99%

COVID‐19 spreading across world correlates with C677T allele of the methylenetetrahydrofolate reductase (MTHFR) gene prevalence

Ponti

Pastorino

Manfredini

et al. 2021

Clinical Laboratory Analysis

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Background Homocysteine assessment has been proposed as a potential predictive biomarker for the severity of COVID‐19 infection. The purpose of this review was to analyze the correlation between the prevalence of MTHFR C677 T gene polymorphism and COVID‐19 incidence and mortality worldwide. Methods Data regarding MTHFR C677 T gene mutation were obtained from the interrogation of the Genome Aggregation Database (genomAD), which is publicly available from the web“ https://gnomad.broadinstitute.org .” COVID‐19 cases, including prevalence and mortality, were obtained from“ https://www.worldometers.info/coronavirus ” 27 August 2020. Results There is a clear trend toward the worldwide prevalence of MTHFR 677 T and COVID‐19 incidence and mortality. The prevalence of MTHFR 677 T allele in the Latino population, and the incidence and mortality for COVID‐19 was higher for this ethnic group than that reported for most other populations globally. Statistical analysis showed a relatively strong correlation between C677 T and death from coronavirus. Conclusions Genetic polymorphism of MTHFR C677 T may modulate the incidence and severity of COVID‐19 pandemic infection.

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“…Hcy, the third mammalian sulfur amino acid, is known since 1932 as a byproduct of the incubation of methionine with sulfuric acid (32), and emerges here as a transsulfuration intermediate. Methionine and cysteine have a proteinogenic role and can be targets for modifications (25,386).…”

Section: Introductionmentioning

confidence: 99%

Mammalian Sulfur Amino Acid Metabolism: A Nexus Between Redox Regulation, Nutrition, Epigenetics, and Detoxification

Pajares

2018

Antioxidants & Redox Signaling

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Increasing the knowledge on transsulfuration outside the liver, understanding the protein-protein interaction networks involving these enzymes, the functional role of their PTMs, or the mechanisms controlling their nucleocytoplasmic shuttling may provide further insights into the pathophysiological implications of this pathway, allowing design of new therapeutic interventions. Antioxid. Redox Signal. 29, 408-452.

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The Formation of a Homologue of Cystine by the Decomposition of Methionine With Sulfuric Acid

Cited by 124 publications

References 6 publications

Assessing Plasma Total Homocysteine in Patients with End-Stage Renal Disease

Assessing Plasma Total Homocysteine in Patients with End-Stage Renal Disease

COVID‐19 spreading across world correlates with C677T allele of the methylenetetrahydrofolate reductase (MTHFR) gene prevalence

Mammalian Sulfur Amino Acid Metabolism: A Nexus Between Redox Regulation, Nutrition, Epigenetics, and Detoxification

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