Abstract:The plant homeodomain zinc finger protein 6 (PHF6) is affected by germline mutations in patients with cognitive disabilities and somatic mutations in acute T-cell leukemia (T-ALL). We and others previously obtained evidence for a key role of PHF6 in hematopoietic precursor cell self-renewal capacity and lineage commitment during differentiation, while recent work revealed a role in non-homologous end joining and G2 checkpoint recovery. In this study, we identified the ribonucleotide reductase subunit M2 (RRM2)… Show more
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