The forgotten electrolyte, when hypercalcaemia manifest as gait instability and altered mental status

Ugalde, Israel; Segura, Manuel Bello; Oneto, Sabrina; Ciment, Ari

doi:10.1136/bcr-2017-224089

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…It is generally defined as the disease of stones, bones, abdominal cavity, and psychogenic complaints. Besides typical symptoms, gait disorder, disequilibrium, and psychiatric disorders, as well as nonspecific symptoms such as cervical and mediastinal hemorrhaging which occurs due to spontaneous laceration of parathyroid adenoma, may appear 6,[24][25][26][27][28] .…”

Section: Discussionmentioning

confidence: 99%

Should We Look For Blood Parathormone in Patients with Vertigo?

Demirbilek¹,

Evren²

2019

Kafkas J Med Sci

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Aim: Though vertigo is a symptom which is defined by an individual as spinning of themselves or an object, it is generally defined by the patients as the sensation of falling, disequilibrium, dizziness and fainting. The main problem on the patients is the determination of the underlying illness. Most of vertigos have peripheral causes and benign paroxysmal positional vertigo takes the first place. It is followed by peripheral and central causes. Patients usually consult the policlinics of Ear, Nose and Throat, internal medicine, neurology in addition to emergency departments with balance disorders. These patients undergo examinations, screening methods, audiology and balance tests and routine blood tests. Material and Method: In this study in which 397 patients who consulted the hospital with complaints of vertigo between 2011 and 2017 evaluated retrospectively. Results: In our study, first of all peripheral causes and 44.8% of these were benign paroxysmal positional vertigo. Hyperparathyroidism was detected in 4 (1%) of the cases in our patient groups that the only complaint was dizziness and there were no other characteristics in the examinations. Parathyroid adenoma was detected in three of them and hyperplasia was detected in the other. In the ones who had adenoma after parathyroidectomy and in the other case after bisphosphonate treatment, both parathormone levels decreased to normal and vertigo complaints totally disappeared. Conclusion: It is recommended that parathormone values should be taken into account in the blood tests during the process of diagnosis in vertigo patients.

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Section: Discussionmentioning

confidence: 99%

Should We Look For Blood Parathormone in Patients with Vertigo?

Demirbilek¹,

Evren²

2019

Kafkas J Med Sci

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“…Low calcium can lead to circumoral or peripheral paranesthesia, tetany, carpopedal spasm, laryngospasm, and ECG changes from long QT interval to VT arrest [1,2]. While high calcium can cause fatigue, polyuria, polydipsia, nephrolithiasis, peptic ulcer disease, altered mental status, gait instability [3][4][5], myalgia, arthralgia, abdominal pain [4], rare submandibular gland atrophy and sialolithiasis, metastatic pulmonary calcification [6,7], sometimes even inducing acute kidney injury or acute pancreatitis [8][9][10][11][12][13], or being life-threatening [14,15]. The parathyroid gland is an adjacent organ of the thyroid.…”

Section: Introductionmentioning

confidence: 99%

Effect of Parathyroid Function After Thyroidectomy and Radioactive-Iodine Therapy for Thyroid Disease

Xiao¹,

Zhang²,

Li³

2019

BJSTR

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Objective: Thyroidectomy and radioactive-iodine (RAI) treatment are two important methods for benign and malignant thyroid diseases. Thyroidectomy and RAI treatment may influence parathyroid gland function. This paper systematically reviewed the literatures on the effect of thyroidectomy and RAI on parathyroid gland function in patients with benign and maligant thyroid disease. Subjective and Methods:We searched PubMed for English literautres by using terms of "thyroidectomy" or "radioactive iodine" and "hyperthyroidism" or "Graves' disease" or "toxic multinodular goiter" or "toxic adenoma" or "differentiated thyroid carcinoma" and "parathyroid gland" or "calcium" or "parathyroid hormone" to review the effect of thyroidectomy and RAI on parathyroid gland function.Result: Thyroidectomy may lead to hypocalcaemia and hypoparathyroidism both for benign thyroid disease and DTC. For benign thyroid disease, RAI treatment may cause increasing PTH in the short term and may induce parathyroid adenoma or hyperplasia in the long term. For DTC patients, parathyroid gland function may transiently decline after RAI treatment. Conclusion:Thyroidectomy and RAI treatment may influence the parathyroid function in both benign and DTC patients. Thus, it is important to monitor PTH and blood calcium regularly in order to detect early abnormal parathyroid function for those patients.

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Hypercalcaemic encephalopathy as a presenting manifestation of sarcoidosis

et al. 2021

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A 66-year-old woman presented to us with features of encephalopathy with asterixis, preceded by unsteadiness of gait and behavioural abnormalities. On subsequent investigations, hypercalcaemic crisis and compromised renal function were noted. Stepwise approach to determine the cause behind hypercalcaemia with compromised renal function revealed underlying granulomatous disease (sarcoidosis). Later, development of maculopapular rash and subsequent biopsy from the lesion confirmed the diagnosis of sarcoidosis. Her clinical and biochemical parameters improved considerably on initiation of conservative pharmacological therapy.

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The forgotten electrolyte, when hypercalcaemia manifest as gait instability and altered mental status

Cited by 3 publications

References 8 publications

Should We Look For Blood Parathormone in Patients with Vertigo?

Should We Look For Blood Parathormone in Patients with Vertigo?

Effect of Parathyroid Function After Thyroidectomy and Radioactive-Iodine Therapy for Thyroid Disease

Hypercalcaemic encephalopathy as a presenting manifestation of sarcoidosis

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