The Force Required to Induce Hemivein Pulsation Is Associated with the Site of Maximum Field Loss in Glaucoma

Morgan, William H.; Balaratnasingam, Chandrakumar; Hazelton, Martin L.; House, Philip; Cringle, Stephen J.; Yu, Dao‐Yi

doi:10.1167/iovs.04-1126

Cited by 41 publications

(37 citation statements)

References 33 publications

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“…Still, improved SVP monitoring could benefit subjects requiring regular or long term ICP monitoring. 7 Various associations have also been reported between SVP and glaucoma: (1) venous pulsation evoked by ophthalmodynamometry indicates higher venous pressure in glaucoma subjects, [8][9][10] (2) SVP incidence is lower in glaucoma, [11][12][13][14] (3) SVP is related to the severity of functional damage, 11,13,15,16 and (4) SVP is predictive of disease progression. [17][18][19] Obviously, SVP could be employed more efficiently if its etiology was better understood.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of Fundus-Image Sequences Reveals Phase of Spontaneous Venous Pulsations

Moret

Reiff

Lagrèze

et al. 2015

Trans. Vis. Sci. Tech.

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Purpose: Spontaneous venous pulsation correlates negatively with elevated intracranial pressure and papilledema, and it relates to glaucoma. Yet, its etiology remains unclear. A key element to elucidate its underlying mechanism is the time at which collapse occurs with respect to the heart cycle, but previous reports are contradictory. We assessed this question in healthy subjects using quantitative measurements of both vein diameters and artery lateral displacements; the latter being used as the marker of the ocular systole time.Methods: We recorded 5-second fundus sequences with a near-infrared scanning laser ophthalmoscope in 12 young healthy subjects. The image sequences were coregistered, cleaned from microsaccades, and filtered via a principal component analysis to remove nonpulsatile dynamic features. Time courses of arterial lateral displacement and of diameter at sites of spontaneous venous pulsation or proximal to the disk were retrieved from those image sequences and compared.Results: Four subjects displayed both arterial and venous pulsatile waveforms. On those, we observed venous diameter waveforms differing markedly among the subjects, ranging from a waveform matching the typical intraocular pressure waveform to a close replica of the arterial waveform. Conclusions:The heterogeneity in waveforms and arteriovenous phases suggests that the mechanism governing the venous outflow resistance differs among healthy subjects.Translational relevance: Further characterizations are necessary to understand the heterogeneous mechanisms governing the venous outflow resistance as this resistance is altered in glaucoma and is instrumental when monitoring intracranial hypertension based on fundus observations.

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Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of Fundus-Image Sequences Reveals Phase of Spontaneous Venous Pulsations

Moret

Reiff

Lagrèze

et al. 2015

Trans. Vis. Sci. Tech.

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“…The Sisler device was less comfortable for volunteers than the others and so it was impractical to routinely take three measurements with this device. However, previously published venous COV data [13] were compared and found to be significantly higher (21.0%) than the OcuDyn (p=0.0014, one-way ANOVA on ranks) but not different from Meditron (p=0.63, one-way ANOVA on ranks).…”

Section: Comparison Of Three Ophthalmodynamometersmentioning

confidence: 83%

“…This provides excellent visualization of the fundus and improved reproducibility of measurements, with coefficients of variation of 16.3% for retinal vein and 8.5% for retinal arterial diastolic forces [11]. This compares favorably to the Sisler ophthalmodynamometer [12], which has a retinal vein coefficient of variation of 21% [13]. All ophthalmodynamometer measurements are in force units without a known intraocular pressure (IOP) correlate so that the induced IOP remains unknown.…”

Section: Introductionmentioning

confidence: 97%

Optimizing the calibration and interpretation of dynamic ocular force measurements

Morgan

Cringle

Kang

et al. 2010

Graefes Arch Clin Exp Ophthalmol

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Linearity between induced IOP and ODF is strong, suggesting that calibration of 0.32 mmHg/g for OcuDyn or using two point blood pressure measures allows for valid interpolation. The better optics of the Meditron and OcuDyn result in more repeatable end-point determination and outweigh benefits conferred by signal averaging or slit lamp mounting. We calculate calibration factors of 0.89 mmHg/arbitrary unit for Meditron and 0.82 mmHg/g for Sisler. These factors may be useful in the estimation of ocular vascular, orbital, and cerebrospinal fluid pressures.

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“…The study may add to the clinical application of modern ophthalmodynamometry as already demonstrated in previous investigations on glaucoma, measurement of intracerebral pressure, assessment of tissue pressure in the orbit in patients with endocrine orbitopathy, ischaemic ophthalmopathy and retinal vein occlusions. [4][5][6][7][8][9][10][11][12] …”

Section: Resultsmentioning

confidence: 99%

Central retinal artery and vein collapse pressure in giant cell arteritis versus nonarteritic anterior ischaemic optic neuropathy

Jonas

Harder

2007

Eye

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Arteritic anterior ischaemic optic neuropathy and nonarteritic anterior ischaemic optic neuropathy are acute optic neuropathies, which have to be differentiated from each other. It was the purpose of this study to assess whether ophthalmodynamometry with an assessment of the collapse pressure of the central retinal artery (CRA) and vein (CRV) is helpful for that. Using a Goldmann contact lens-associated ophthalmodynamometer, the diastolic collapse pressure of the CRA and CRV were measured in six patients (eight eyes) with giant cell arteritis-induced anterior ischaemic optic neuropathy (GC-AION) and in 10 patients (12 eyes) with acute non-arteritic anterior ischaemic optic neuropathy (NAION). CRA collapse pressure was significantly (P ¼ 0.001; 95% confidence interval (CI): À68.7, À20.0) lower in the GC-AION group (52.7724.6 arbitrary units) than in the NAION group (97.0725.8 arbitrary units). CRV collapse pressure did not vary significantly (P ¼ 0.47). As measured by ophthalmodynamometry, CRA pressure is significantly lower in GC-AION than in NAION. CRV pressure does not vary markedly. These finding may be helpful for the clinical differentiation between GC-AION and NAION, and may give hints for the pathogenesis.

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The Force Required to Induce Hemivein Pulsation Is Associated with the Site of Maximum Field Loss in Glaucoma

Abstract: These venous pulsation findings in glaucoma are independent of blood pressure. The hemifield and hemivein association suggests that the major hemivein change is adjacent to the site of major disc damage.

Cited by 41 publications

References 33 publications

Quantitative Analysis of Fundus-Image Sequences Reveals Phase of Spontaneous Venous Pulsations

Quantitative Analysis of Fundus-Image Sequences Reveals Phase of Spontaneous Venous Pulsations

Optimizing the calibration and interpretation of dynamic ocular force measurements

Central retinal artery and vein collapse pressure in giant cell arteritis versus nonarteritic anterior ischaemic optic neuropathy

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