The Follicular IGFBP Changes after Metformine Administration in Polycystic Ovary Syndrome and its Impact on the Fertility Rate. A randomized Study

Surcel, Mihai

doi:10.4183/aeb.2013.383

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“…We identified 41 studies that reported on OHSS. Low‐quality evidence suggested that antagonist protocols are associated with a lower risk for developing OHSS than are agonist protocols.…”

Section: Resultsmentioning

confidence: 99%

Strategies for improving outcome of assisted reproduction in women with polycystic ovary syndrome: systematic review and meta‐analysis

Kollmann

Martins

Lima

et al. 2016

Ultrasound in Obstet & Gyne

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“…We identified 41 studies that reported on OHSS. Low‐quality evidence suggested that antagonist protocols are associated with a lower risk for developing OHSS than are agonist protocols.…”

Section: Resultsmentioning

confidence: 99%

Strategies for improving outcome of assisted reproduction in women with polycystic ovary syndrome: systematic review and meta‐analysis

Kollmann

Martins

Lima

et al. 2016

Ultrasound in Obstet & Gyne

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show abstract

“…Insulin sensitizers and antiandrogens may have complementary effects in the treatment of PCOS. Metformin ameliorates hyperinsulinemia and hirsutism, and restores regular menses and spontaneous ovulation (14)(15)(16). Another drug, finasteride, is a competitive inhibitor of 5-alpha-reductase, which converts testosterone into its more potent androgenic metabolite, dihydrotestosterone (DHT).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Finasteride, Metformin, and Finasteride Plus Metformin in PCOS

et al. 2017

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The effects of finasteride on insulin resistance and of metformin on hyperandrogenism in patients with polycystic ovary syndrome (PCOS) are not clear. This study therefore compared the effects of finasteride, metformin, and finasteride plus metformin treatments on hormone levels, insulin resistance, and hirsutism score in women with PCOS. Fifty-two patients with PCOS were randomly assigned to receive finasteride 5 mg/day, metformin 1700 mg/day or finasteride plus metformin for 12 months. Body mass index (BMI), Ferriman Gallway score (FGS), serum concentrations of estradiol, sex hormone-binding globulin, free testosterone, dehydroepiandrosterone sulfate (DHEAS), androstenedione, and homeostasis model assessment of insulin resistance (HOMA-IR) index and areas under the curve (AUC) for insulin and glucose were evaluated before and after 12 months of treatment. Reductions in FGS, free testosterone, DHEAS, androstenedione, HOMA-IR, AUCinsulin, and AUC-glucose were significant within each group, whereas BMI and estradiol were not. Comparisons of changes in parameters in the 3 groups did not clearly show the superiority of any treatment modality. The treatment with finasteride alone significantly reduced both androgen levels and parameters of insulin resistance. In addition, metformin alone was effective, and not inferior to finasteride, in the treatment of hyperandrogenism.

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The Follicular IGFBP Changes after Metformine Administration in Polycystic Ovary Syndrome and its Impact on the Fertility Rate. A randomized Study

Cited by 2 publications

References 0 publications

Strategies for improving outcome of assisted reproduction in women with polycystic ovary syndrome: systematic review and meta‐analysis

Strategies for improving outcome of assisted reproduction in women with polycystic ovary syndrome: systematic review and meta‐analysis

Comparison of Finasteride, Metformin, and Finasteride Plus Metformin in PCOS

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