The Follicular Endocrine Environment in Stimulated Cycles of Women with Endometriosis: Steroid Levels and Embryo Quality

Pellicer, A.; Valbuena, Diana; Bauset, C; Albert, Carmela; Bonilla‐Musoles, Fernando; Remohı́, José; Simón, Carlos

doi:10.1016/s0015-0282(98)00085-5

Cited by 70 publications

(50 citation statements)

References 21 publications

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“…We have found a significantly decreased follicular fluid concentration of estradiol in endometriosis patients compared to controls, but no difference in progesterone levels which is in contrast to Pellicer et al (19) who found that these levels were increasing with the severity of the disease. This discrepancy is difficult to explain, but it may be related to lower numbers in the mentioned study (particularly the controls) and to different distribution of the patients between the various types of infertility (tubal vs. male) in the control group.…”

Section: Discussioncontrasting

confidence: 85%

Steroids and protein markers in the follicular fluid as indicators of oocyte quality in patients with and without endometriosis

Wunder

Mueller

Birkhäuser

et al. 2005

J Assist Reprod Genet

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Section: Discussioncontrasting

confidence: 85%

Steroids and protein markers in the follicular fluid as indicators of oocyte quality in patients with and without endometriosis

Wunder

Mueller

Birkhäuser

et al. 2005

J Assist Reprod Genet

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“…Previous studies by Pellicer et al (2) have shwon that, although the steroid levels in FF differ significantly between follicles of women with and without endometriosis, there is no way to predict the differences in embryo quality between the two groups. In contrast, the values for progesterone and the estradiol/ testosterone ratio were higher in oocytes with poorer prognosis (endometriosis).…”

Section: Discussionmentioning

confidence: 96%

“…Since the corona-cumulus-oocyte complex is in close contact with FF, an association is believed to exist between the hormonal content of FF and the quality and degree of oocyte maturity, and therefore FF hormonal content is presumed to be related to fertilization and embryo development and implantation rate (1,2).…”

Section: Introductionmentioning

confidence: 99%

Estradiol and testosterone concentrations in follicular fluid as criteria to discriminate between mature and immature oocytes

Costa

Mendes

Ferriani

et al. 2004

Braz J Med Biol Res

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The objective of the present study was to examine the association between follicular fluid (FF) steroid concentration and oocyte maturity and fertilization rates. Seventeen infertile patients were submitted to ovulation induction with urinary human follicle-stimulating hormone, human menopausal gonadotropin and human chorionic gonadotropin (hCG). A total of 107 follicles were aspirated after hCG administration, the oocytes were analyzed for maturity and 81 of them were incubated and inseminated in vitro. Progesterone, estradiol (E2), estrone, androstenedione, and testosterone were measured in the FF. E2 and testosterone levels were significantly higher in FF containing immature oocytes (median = 618.2 and 16 ng/ml, respectively) than in FF containing mature oocytes (median = 368 and 5.7 ng/ml, respectively; P < 0.05). Progesterone, androstenedione and estrone levels were not significantly different between mature and immature oocytes. The application of the receiver-operating characteristic curve statistical approach to determine the best cut-off point for the discrimination between mature and immature oocytes indicated levels of 505.8 ng/ml for E2 (81.0% sensitivity and 81.8% specificity) and of 10.4 ng/ ml for testosterone (90.9% sensitivity and 82.4% specificity). Follicular diameter was associated negatively with E2 and testosterone levels in FF. There was a significant increase in progesterone/testosterone, progesterone/E2 and E2/testosterone ratios in FF containing mature oocytes, suggesting a reduction in conversion of C21 to C19, but not in aromatase activity. The overall fertility rate was 61% but there was no correlation between the steroid levels or their ratios and the fertilization rates. E2 and testosterone levels in FF may be used as a predictive parameter of oocyte maturity, but not for the in vitro fertilization rate.

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“…A function defect in the oocyte due to abnormal follicle function might be the result of this ovulatory dysfunction (Wardle et al, 1985). Supporting this hypothesis, clinical studies involving IVF and some programs of oocyte donation have pointed out the importance of impaired oocyte quality in the pathogenesis of infertility associated with endometriosis (Pellicer et al, 1998;Garrido et al, 2002).…”

Section: Endometriosis Steroidogenesis and Folliculogenesismentioning

confidence: 97%

Endometriosis and Infertility: The Role of Oxidative Stress

Barcelos¹,

Navarro²

2012

Endometriosis - Basic Concepts and Current Research Trends

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The Follicular Endocrine Environment in Stimulated Cycles of Women with Endometriosis: Steroid Levels and Embryo Quality

Cited by 70 publications

References 21 publications

Steroids and protein markers in the follicular fluid as indicators of oocyte quality in patients with and without endometriosis

Steroids and protein markers in the follicular fluid as indicators of oocyte quality in patients with and without endometriosis

Estradiol and testosterone concentrations in follicular fluid as criteria to discriminate between mature and immature oocytes

Endometriosis and Infertility: The Role of Oxidative Stress

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