The Flow’s the Thing…︁Or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow

Valera, Fernando; Quaranta, Michela; Morán, Antonio; Blacker, John; Armstrong, Alan; Cabral, João T.; Blackmond, Donna G.

doi:10.1002/anie.200906095

Cited by 185 publications

(128 citation statements)

References 28 publications

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“…With this in mind, the calculation of rate constants has many purposes, including the determination of the rate-determining step and effects of structure and the medium on reactivity [3,57,[85][86][87]. The few examples in the following illustrate the power of chemical kinetics in probing reaction mechanism.…”

Section: Mechanistic Interpretationmentioning

confidence: 99%

Practical Chemical Kinetics in Solution

Seoud

Baader

Bastos

2016

Encyclopedia of Physical Organic Chemistry, 5 Volume Set

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Section: Mechanistic Interpretationmentioning

confidence: 99%

Practical Chemical Kinetics in Solution

Seoud

Baader

Bastos

2016

Encyclopedia of Physical Organic Chemistry, 5 Volume Set

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“…"流动化学(Flow chemistry)" [1d] : 或称为"连续流化学(Continuous flow chemistry)" [19] , 是指通过泵输送物料并以连续流动模式进行化学反应的技术. 尽管流动化学在诸如石油化工行业的大宗化学品生产中是非常成熟的技术, 但在药物合成等精细化工行业尤其是实验室研发阶段, 该技术还是相对较新的概念.…”

Section: 相关术语介绍unclassified

Updated Applications of Flow Chemistry in Pharmaceutical Synthesis

Zhao¹

2013

Chin. J. Org. Chem.

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As a further-developing process intensification technology, flow chemistry has achieved a striking development either in academic or industrial area in the past decade. Updated applications of flow chemistry in pharmaceutical synthesis are overviewed. Compared with its early research and development (R&D), current flow chemistry has already shown a lot of breakthroughs. For instance, no more limitations to the proof of feasibility concept for some certain reaction, public development of this technology by more and more distinguished international pharmaceutical companies and quite a few corresponding reports of successful examples about multistep total synthesis of active pharmaceutical ingredients (APIs). Different process categorizations are emphasized with many API syntheses to demonstrate the up-to-date progress of this topic, after a brief introduction of the advantages, existing challenges and the corresponding solutions for flow chemistry.

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“…Several micro-and mesofluidic systems were developed and characterized [12][13][14][15], such as medical diagnostic devices with integrated biosensors [16], circulating tumor cell capture systems [17], gradient concentration generators [18], photocatalytic water purification [19], and organic and inorganic synthetic flow reactors [9]. Despite good results, the main disadvantage of small-scale reactors is the relatively high cost combined with the low output of a single reactor and the unfeasibility of production on a commercial scale [20]. Nevertheless, a continuous-flow reactor can be numbered-up without further testing for a large-scale production; another alternative is scaling-up the volume of the flow reactor system with a mesoreactor device for industrial application [21].…”

Section: Introductionmentioning

confidence: 99%

Prototyping of Meso- and Microfluidic Devices with Embedded TiO2 Photocatalyst for Photodegradation of an Organic Dye

Sá¹,

Marinković²,

Romani³

et al. 2016

J Flow Chem

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We present prototyping of meso-and microfluidic photocatalytic devices, functionalized through incorporation of TiO 2 nanoparticles in polydimethylsiloxane (PDMS), and comparison of their efficiencies for the degradation of rhodamine B (10 −5 mol/L). The prototyping of the photocatalytic devices involves simple and low-cost procedures, which includes microchannels fabrication on PDMS, deposition and impregnation of TiO 2 on PDMS, and, finally, plugging on the individual parts. For the microfluidic device with 13 μL internal volume, photocatalytic TiO 2 -PDMS composite was sealed by another PDMS component activated by O 2 plasma (PDMS-TiO 2 -PDMS). For the mesofluidic device, a homemade polyetheretherketone (PEEK) flow cell with 800 μL internal volume was screwed on a steel support with a glass slide and the photocatalytic composite. The photocatalytic activities of the devices were evaluated using two different pumping flow systems: a peristaltic pump and a syringe pump, both at 0.05 mL/min under the action of 365 nm ultraviolet (UV) light. The characterization of TiO 2 -PDMS composite was performed by confocal Raman microscopy, scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS). The photocatalytic microreactor was the most efficient, showing high organic dye photodegradation (88.4% at 12.5 mW/cm 2 ).

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The Flow’s the Thing…︁Or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow

Cited by 185 publications

References 28 publications

Practical Chemical Kinetics in Solution

Practical Chemical Kinetics in Solution

Updated Applications of Flow Chemistry in Pharmaceutical Synthesis

Prototyping of Meso- and Microfluidic Devices with Embedded TiO2 Photocatalyst for Photodegradation of an Organic Dye

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