The flexibility of cognitive reserve in regulating the frontoparietal control network and cognitive function in subjects with white matter hyperintensities

Chen, Huiping; Zhu, Huahong; Huang, Lili; Chen, Haifeng; Liu, Renyuan; Qin, Ruomeng; Shao, Pengfei; Xu, Hengheng; Ma, Jun; Cheng, Yue; Xu, Yun; Ye, Qing

doi:10.1016/j.bbr.2022.113831

Cited by 13 publications

(11 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In cross-sectional study, except for VAN-VN connectivity, VAN-DMN, VAN-FPCN, and VAN-RN connectivity were also associated with normal-cognition. Previous studies found that DMN, FPCN, and RN were all associated with cognition [31][32][33]. As VAN participates in stimulus-driven attention allocation [27,28], higher VAN-DMN, VAN-FPCN, and VAN-RN connectivity may indicate more efficient stimulus-driven cognitive processing.…”

Section: Discussionmentioning

confidence: 90%

Higher Functional Connectivity of Ventral Attention and Visual Network to Maintain Cognitive Performance in White Matter Hyperintensity

Zhu¹,

Zhou²,

Zhong³

et al. 2022

Aging and disease

View full text Add to dashboard Cite

Ventral attention network (VAN), associated with cognitive performance, is one of the functional networks that are most vulnerable in white matter hyperintensity (WMH). Considering the global interaction of networks for cognitive performance, we hypothesized that VAN-related between-network connectivity might play a role in maintaining cognition in patients with WMH. We included 139 participants for both cross-sectional and longitudinal analysis from CIRCLE study (ClinicalTrials.gov ID: NCT03542734) between January 2014 and January 2021. Differences of VAN-related between-network connectivity were compared between normalcognition (NC) and cognitive-impairment (CI) groups cross-sectionally, and between cognitive-decline (CD) and cognitive non-decline (CND) groups longitudinally by using t-test. False Discovery Rate was used for multiple comparison correction. The relationship between the network connectivity and WMH was tested on linear and quadratic models. Subgroup analysis of different WMH burdens were performed to test the difference of network connectivity between NC and CI groups. Among VAN-related between-network connectivity, only VAN-Visual Network (VN) connectivity was higher both in NC (n = 106) and CND (n = 113) groups versus CI (n = 33) and CD groups (n = 26), respectively. There was an inverted U-shaped relation between periventricular WMH (PWMH) burden and VAN-VN connectivity. Normal-cognition participants had higher VAN-VN connectivity among high, but not low PWMH burden subgroups. These findings suggest that the VAN-VN connectivity plays an important role in maintaining cognitive performance in WMH patients. It may serve as a unique marker for cognitive prediction and a potential target for intervention to prevent cognitive decline in WMH patients.

show abstract

Section: Discussionmentioning

confidence: 90%

Higher Functional Connectivity of Ventral Attention and Visual Network to Maintain Cognitive Performance in White Matter Hyperintensity

Zhu¹,

Zhou²,

Zhong³

et al. 2022

Aging and disease

View full text Add to dashboard Cite

show abstract

“…The FPN, on the other hand, is intricately linked with cognitive control and executive functions ( Ptak, 2012 ). Greater FPN within-network connectivity was found to mitigate the effect of white matter lesions on executive dysfunction and is relevant to greater cognitive reserve ( Chen et al, 2022 ). In light of the well-recognized bidirectional relationship between cognition and mobility ( Camicioli, 2017 ), the merits of modular network organization may be extrapolated to mobility and postural control.…”

Section: Discussionmentioning

confidence: 99%

Six month lower-leg mechanical tactile sensory stimulation alters functional network connectivity associated with improved gait in older adults with peripheral neuropathy – A pilot study

Hsu

Manor

Iloputaife

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

Foot sole somatosensory impairment associated with peripheral neuropathy (PN) is prevalent and a strong independent risk factor for gait disturbance and falls in older adults. Walkasins, a lower-limb sensory prosthesis, has been shown to improve gait and mobility in people with PN by providing afferent input related to foot sole pressure distributions via lower-leg mechanical tactile stimulation. Given that gait and mobility are regulated by sensorimotor and cognitive brain networks, it is plausible improvements in gait and mobility from wearing the Walkasins may be associated with elicited neuroplastic changes in the brain. As such, this study aimed to examine changes in brain network connectivity after 26 weeks of daily use of the prosthesis among individuals with diagnosed PN and balance problems. In this exploratory investigation, assessments of participant characteristics, Functional Gait Assessment (FGA), and resting-state functional magnetic resonance imaging were completed at study baseline and 26 weeks follow-up. We found that among those who have completed the study (N = 8; mean age 73.7 years) we observed a five-point improvement in FGA performance as well as significant changes in network connectivity over the 26 weeks that were correlated with improved FGA performance. Specifically, greater improvement in FGA score over 26 weeks was associated with increased connectivity within the Default Mode Network (DMN; p < 0.01), the Somatosensory Network (SMN; p < 0.01), and the Frontoparietal Network (FPN; p < 0.01). FGA improvement was also correlated with increased connectivity between the DMN and the FPN (p < 0.01), and decreased connectivity between the SMN and both the FPN (p < 0.01) and cerebellum (p < 0.01). These findings suggest that 26 weeks of daily use of the Walkasins device may provide beneficial neural modulatory changes in brain network connectivity via the sensory replacement stimulation that are relevant to gait improvements among older adults with PN.

show abstract

“…Lesion Segmentation Toolbox version 2.0.15 ( www.statistical-modelling.de/lst.html ) for Statistical Parametric Mapping software (SPM) 12 ( http://www.fil.ion.ucl.ac.uk/spm ) was used to semi‐automatically quantify WMH volume based on 3D‐T1 weighted and FLAIR images. The detailed procedures were described in our previous study (H. Chen et al, 2022 ). In brief, the Lesion Growth Algorithm function was applied at a threshold of κ = 0.15 and the resulting individual WMH volume presented in an HTML report.…”

Section: Methodsmentioning

confidence: 99%

Subsystem mechanisms of default mode network underlying white matter hyperintensity‐related cognitive impairment

Yang

et al. 2023

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

Functional changes of default mode network (DMN) have been proven to be closely associated with white matter hyperintensity (WMH) related cognitive impairment (CI). However, subsystem mechanisms of DMN underlying WMH‐related CI remain unclear. The present study recruited WMH patients ( n = 206) with mild CI and normal cognition, as well as healthy controls (HC, n = 102). Static/dynamic functional connectivity (FC) of the DMN's three subsystems were calculated using resting‐state functional MRI. K‐means clustering analyses were performed to extract distinct dynamic connectivity states. Compared with the WMH‐NC group, the WMH‐MCI group displayed lower static FC within medial temporal lobe (MTL) and core subsystem, between core‐MTL subsystem, as well as between core and dorsal medial prefrontal cortex subsystem. All these static alterations were positively associated with information processing speed (IPS). Regarding dynamic FC, the WMH‐MCI group exhibited higher dynamic FC within MTL subsystem than the HC and WMH‐NC groups. Altered dynamic FC within MTL subsystem mediated the relationship between WMH and memory span (indirect effect: −0.2251, 95% confidence interval [−0.6295, −0.0267]). Additionally, dynamic FCs of DMN subsystems could be clustered into two recurring states. For dynamic FCs within MTL subsystem, WMH‐MCI subjects exhibited longer mean dwell time (MDT) and higher reoccurrence fraction (RF) in a sparsely connected state (State 2). Altered MDT and RF in State 2 were negatively associated with IPS. Taken together, these findings indicated static/dynamic FC of DMN subsystems can provide relevant information on cognitive decline from different aspects, which provides a comprehensive view of subsystem mechanisms of DMN underlying WMH‐related CI.

show abstract

The flexibility of cognitive reserve in regulating the frontoparietal control network and cognitive function in subjects with white matter hyperintensities

Cited by 13 publications

References 48 publications

Higher Functional Connectivity of Ventral Attention and Visual Network to Maintain Cognitive Performance in White Matter Hyperintensity

Higher Functional Connectivity of Ventral Attention and Visual Network to Maintain Cognitive Performance in White Matter Hyperintensity

Six month lower-leg mechanical tactile sensory stimulation alters functional network connectivity associated with improved gait in older adults with peripheral neuropathy – A pilot study

Subsystem mechanisms of default mode network underlying white matter hyperintensity‐related cognitive impairment

Contact Info

Product

Resources

About