The flavonoids of okra insulates against oxidative stress, neuroinflammation and restores BDNF levels in Aβ1–42 induced mouse model of Alzheimer's disease

Effects of okra (Abelmoschus esculentusL) on inflammatory mediators: a systematic review of preclinical studies

“…The flavonoid contents found in okra fruit were reported to diminish the TNF-α release by inhibiting NF-κB as an oxidative product that contributed to the expression of genes involved in inflammation. 28 It has been shown that oxidative stress has a serious role in the pathogenesis of alcoholic liver diseases as well as the accumulation of fat in hepatic tissue as a result of alcohol consumption, thereby leading to the activation of the inflammatory system and cytokine release. 30 Okra extracts have also been effective in the substantial reduction of TNF-α levels in animals with tetrachloride carbon-induced liver injuries.…”

“…Considering the inclusion criteria, 16 animal studies were included in the current systematic review (Table 2). Yan et al 28 reported that 100 and 300 mg per kg body weight (BW) of fla-vonoids of okra fruit for 4 weeks significantly reduced IL-1β and TNF-α in the hippocampus and cerebral cortex in mice with Aβ1-42 induced Alzheimer's disease compared with the lesioned control group. In a study in mice with induced acute pancreatitis, Xiong et al 29 reported that 200 mg per kg BW okra pectin and/or crude okra pectin for 5 days significantly reduced the IL-6 levels in serum, pancreas, and colon compared to acute pancreatitis controls.…”

Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer’s Disease: Beneficial Effects of Flavonoids for Neuroprotection

“…Melatonin also influences CREB expression. Yan et al reported the beneficial effect of flavonoids extracted from okra fruit (FOF), which is a tropical vegetable that has been used as a natural drug in east and west Africa for many centuries [ 84 ]. Intragastric infusion of FOF for 4 weeks in acute model of AD (with intracerebroventricular injection of Aβ1–42) upregulated BDNF expression levels and activated CREB/ERK and PI3K/Akt/GSK-3β signaling pathways and was accompanied by an improvement in cognitive deficits.…”

Identification and Quantification of Flavonoids in Okra (Abelmoschus esculentus L. Moench) and Antiproliferative Activity In Vitro of Four Main Components Identified

“…Long-term eating of flavonoid-rich foods has been associated with reduced risk for certain pathogens and a number of health benefits [1,2], such as resisting bacterial and viral infections, attenuating oxidative stress, cytoprotection, preventing platelet aggregation, cardiovascular and age-related neurodegenerative diseases prevention [3,4], and reducing the Alzheimer's associated symptoms [5,6].…”

“…Okra (Abelmoschus esculentus L. Moench) is an annual plant and is believed to originate near Ethiopia in Africa [7,8], which was used for both medicinal and culinary purposes. A variety of health functions of okra, such as reducing blood-sugar and fat [9,10], antifatigue [11], antioxidant capacity and reducing inflammatory response in ethanol-induced acute gastricmucosal injury and providing neuroprotection in neurodegeneration diseases such as Alzheimer's disease have been reported in recent years [6,11,12].…”