The flavonoid quercetin inhibits titanium dioxide (TiO 2 )-induced chronic arthritis in mice

Borghi, Sérgio M.; Mizokami, Sandra S.; Pinho‐Ribeiro, Felipe A.; Fattori, Victor; Crespigio, Jefferson; Clemente-Napimoga, Juliana Trindade; Napimoga, Marcelo Henrique; Pitol, Dimítrius Leonardo; Issa, João Paulo Mardegan; Fukada, Sandra Yasuyo; Casagrande, Rúbia; Verri, Waldiceu A.

doi:10.1016/j.jnutbio.2017.10.010

Cited by 69 publications

(57 citation statements)

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“…The red arrows represent endogenous pathways that are inhibited by flavonoids resulting in reduced pain and inflammation. , NF-κB [51] and Nrf2 [52], Quercetin: MAPK [53], NF-κB [53][54][55], AKT [56], Nrf2 [33,54], and NLRP3 [57] and Naringenin: NF-κB [58][59][60] and Nrf2 [59,61,62]. (B) Ion channels expressed by neurons that are targeted by Vitexin, Quercetin, and Naringenin to reduce pain.…”

Section: Pre-clinical Evidence Of Flavonoids For Pain Controlmentioning

confidence: 99%

“…Flavonoids are known to have analgesic, anti-inflammatory, and antioxidant properties. These effects are related to the inhibition of NF-κB-dependent pro-inflammatory cytokines [33], VEGF, ICAM-1, STAT3 [34], and activation of antioxidant transcription factor Nrf2 [33]. Many flavonoids, as apigenin and vitexin, were reported to be safe natural alternative therapeutic against neuroinflammatory diseases as such Multiple Sclerosis (MS) [35,36].…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

et al. 2020

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Pathological pain can be initiated after inflammation and/or peripheral nerve injury. It is a consequence of the pathological functioning of the nervous system rather than only a symptom. In fact, pain is a significant social, health, and economic burden worldwide. Flavonoids are plant derivative compounds easily found in several fruits and vegetables and consumed in the daily food intake. Flavonoids vary in terms of classes, and while structurally unique, they share a basic structure formed by three rings, known as the flavan nucleus. Structural differences can be found in the pattern of substitution in one of these rings. The hydroxyl group (-OH) position in one of the rings determines the mechanisms of action of the flavonoids and reveals a complex multifunctional activity. Flavonoids have been widely used for their antioxidant, analgesic, and anti-inflammatory effects along with safe preclinical and clinical profiles. In this review, we discuss the preclinical and clinical evidence on the analgesic and anti-inflammatory proprieties of flavonoids. We also focus on how the development of formulations containing flavonoids, along with the understanding of their structure-activity relationship, can be harnessed to identify novel flavonoid-based therapies to treat pathological pain and inflammation.

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Section: Pre-clinical Evidence Of Flavonoids For Pain Controlmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

et al. 2020

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“…Enzymatic antioxidant defenses are composed of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase, while nonenzymatic systems comprise substances such as vitamin C, vitamin E, carotenoids, and flavonoids. 17,18 Quercetin is an exogenous anti-inflammatory and antioxidant compound belonging to the flavonoid class of polyphenols, [19][20][21][22] and also has anticarcinogenic, analgesic, antihypertensive, and antiulcer effects. 19,23 Clinical and experimental data have shown the cardio-and bowelprotective functions of this flavonoid.…”

mentioning

confidence: 99%

“…17,18 Quercetin is an exogenous anti-inflammatory and antioxidant compound belonging to the flavonoid class of polyphenols, [19][20][21][22] and also has anticarcinogenic, analgesic, antihypertensive, and antiulcer effects. 19,23 Clinical and experimental data have shown the cardio-and bowelprotective functions of this flavonoid. [19][20][21][22] Several fruits and vegetables including capers, dill, cilantro, broccoli, onions, and various berries (such as chokeberries, cranberries, and lingonberries) contain quercetin.…”

mentioning

confidence: 99%

“…19,23 Clinical and experimental data have shown the cardio-and bowelprotective functions of this flavonoid. [19][20][21][22] Several fruits and vegetables including capers, dill, cilantro, broccoli, onions, and various berries (such as chokeberries, cranberries, and lingonberries) contain quercetin. 24,25 Quercetin fights oxidative stress by eliminating free radicals and inhibiting oxidation of many molecules.…”

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confidence: 99%

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Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

Saccol

Silveira

Manzoni

et al. 2019

J of Cellular Biochemistry

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Rheumatoid arthritis is a highly debilitating inflammatory autoimmune disease which is characterized by joint destruction. The present study sought to investigate the effect of quercetin in rats with complete Freund's adjuvant‐induced arthritis. Animals were divided into control/saline, control/quercetin (5 mg/kg, 25 mg/kg, and 50 mg/kg) arthritis/saline, and arthritis/quercetin (5 mg/kg, 25 mg/kg, and 50 mg/kg); the treatments were administered for 45 days. Biochemical, oxidative stress, genotoxicity, and cytotoxicity parameters were evaluated. All doses of quercetin reduced the levels of aspartate aminotransferase, thiobarbituric acid‐reactive substances, and reactive oxygen species; however, only treatment with 25 or 50 mg/kg increased catalase activity. Total thiol and reduced glutathione levels were not significantly affected by the induction nor by the treatments. Genotoxicity assessed by DNA damage, and cytotoxicity through picogreen assay, decreased after treatments with quercetin. Our results present evidence of the antioxidant, cytoprotective, genoprotective and hepatoprotective, and effects of quercetin, demonstrating its potential as a candidate for coadjuvant therapy.

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COand Pain Management

Pol¹

2022

Carbon Monoxide in Drug Discovery

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The flavonoid quercetin inhibits titanium dioxide (TiO 2 )-induced chronic arthritis in mice

Cited by 69 publications

References 69 publications

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

COand Pain Management

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