The flavonoid luteolin reduces mutant huntingtin aggregation and cytotoxicity in huntingtin-mutated neuroblastoma cells

Ramadan, Azza; Mohammed, Abuelnor; Elnour, Asim Ahmed; Sadeq, Adel; Al Mazrouei, Nadia; Alkaabi, Maisoun; Al-Kubaisi, Khalid Awad; Beshir, Semira Abdi; Menon, Vineetha; AlAmoodi, Abdulla; Sam, Kishore Ganana; Saeed, Ali Awadallah Ali Mohamed; Abdalla, Sami Fatehi; Hussein, Samah Mohammed

doi:10.1016/j.jsps.2023.101871

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…In addition, luteolin reduces ROS levels and oxidative stress (in HD generated by, among others, the aggregation of mutant huntingtin) by increasing the levels of enzymes and compounds with antioxidant properties, like superoxide dismutase (SOD), glutathione peroxidase and catalase (CAT) [ 80 ]. Additionally, in a mouse model of HD, luteolin was shown to stimulate the Nrf2-HO-1 antioxidant pathway [ 81 ]. Studies with a cellular model of HD confirmed that luteolin effectively reduced levels of mHTT aggregates and protected cells from the cytotoxic effects of the mutation in HTT [ 81 ].…”

Section: Overview Of the Use Of Flavonoids In Neurodegenerative Disor...mentioning

confidence: 99%

“…Additionally, in a mouse model of HD, luteolin was shown to stimulate the Nrf2-HO-1 antioxidant pathway [ 81 ]. Studies with a cellular model of HD confirmed that luteolin effectively reduced levels of mHTT aggregates and protected cells from the cytotoxic effects of the mutation in HTT [ 81 ]. Experiments with the Drosophila model confirmed the results obtained in studies with cell lines, additionally indicating a delay in the loss of motile functions in flies treated with luteolin [ 82 ].…”

Section: Overview Of the Use Of Flavonoids In Neurodegenerative Disor...mentioning

confidence: 99%

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Effectiveness of Flavonoid-Rich Diet in Alleviating Symptoms of Neurodegenerative Diseases

Szulc,

Wiśniewska,

Żabińska

et al. 2024

Foods

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Over the past decades, there has been a significant increase in the burden of neurological diseases, including neurodegenerative disorders, on a global scale. This is linked to a widespread demographic trend in which developed societies are aging, leading to an increased proportion of elderly individuals and, concurrently, an increase in the number of those afflicted, posing one of the main public health challenges for the coming decades. The complex pathomechanisms of neurodegenerative diseases and resulting varied symptoms, which differ depending on the disease, environment, and lifestyle of the patients, make searching for therapies for this group of disorders a formidable challenge. Currently, most neurodegenerative diseases are considered incurable. An important aspect in the fight against and prevention of neurodegenerative diseases may be broadly understood lifestyle choices, and more specifically, what we will focus on in this review, a diet. One proposal that may help in the fight against the spread of neurodegenerative diseases is a diet rich in flavonoids. Flavonoids are compounds widely found in products considered healthy, such as fruits, vegetables, and herbs. Many studies indicated not only the neuroprotective effects of these compounds but also their ability to reverse changes occurring during the progression of diseases such as Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis. Here, we present the main groups of flavonoids, discussing their characteristics and mechanisms of action. The most widely described mechanisms point to neuroprotective functions due to strong antioxidant and anti-inflammatory effects, accompanied with their ability to penetrate the blood-brain barrier, as well as the ability to inhibit the formation of protein aggregates. The latter feature, together with promoting removal of the aggregates is especially important in neurodegenerative diseases. We discuss a therapeutic potential of selected flavonoids in the fight against neurodegenerative diseases, based on in vitro studies, and their impact when included in the diet of animals (laboratory research) and humans (population studies). Thus, this review summarizes flavonoids’ actions and impacts on neurodegenerative diseases. Therapeutic use of these compounds in the future is potentially possible but depends on overcoming key challenges such as low bioavailability, determining the therapeutic dose, and defining what a flavonoid-rich diet is and determining its potential negative effects. This review also suggests further research directions to address these challenges.

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Section: Overview Of the Use Of Flavonoids In Neurodegenerative Disor...mentioning

confidence: 99%

Section: Overview Of the Use Of Flavonoids In Neurodegenerative Disor...mentioning

confidence: 99%

Effectiveness of Flavonoid-Rich Diet in Alleviating Symptoms of Neurodegenerative Diseases

Szulc,

Wiśniewska,

Żabińska

et al. 2024

Foods

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Phytochemical Importance of Medicinal Plants as Potential Sources Against Neurodegenerative Diseases

Pandey,

Chakrabarty

2024

Sustainable Landscape Planning and Natural Resources Management

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Exploring the thermodynamics of protein aggregation: an insight to Huntington's disease therapeutics

Kaundal,

Pandey,

Pandey

2024

Neurosci Behav Physi

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The flavonoid luteolin reduces mutant huntingtin aggregation and cytotoxicity in huntingtin-mutated neuroblastoma cells

Cited by 4 publications

References 48 publications

Effectiveness of Flavonoid-Rich Diet in Alleviating Symptoms of Neurodegenerative Diseases

Effectiveness of Flavonoid-Rich Diet in Alleviating Symptoms of Neurodegenerative Diseases

Phytochemical Importance of Medicinal Plants as Potential Sources Against Neurodegenerative Diseases

Exploring the thermodynamics of protein aggregation: an insight to Huntington's disease therapeutics

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