The Flavonoid Kaempferol Suppresses the Graft-versus-Host Reaction by Inhibiting Type 1 Cytokine Production and CD8+ T Cell Engraftment

Enhancement of Interleukin-2 Production in CCRF-CEM, Human T-Cell Leukemia, by Tea Flavonols

“…However, we did not clarify why different influences were observed between kaempferol or quercetin and myricetin. Recent reports showed that kaempferol suppressed interferon-γ and IL-2 production in an in vivo experiment 8 . These results differ between in vivo and in vitro experiments, so it is necessary to analyze more in vitro experiments using T-cell leukemia.…”

Kaempferol from Semen cuscutae attenuates the immune function of dendritic cells

“…A number of reports have shown the immunomodulatory effect of kaempferol on T lymphocytes (Okamoto et al 2002), B cells (Zunino and Storms 2009), macrophages (Comalada et al 2006;Hamalainen et al 2007;Harasstani et al 2010;Kim et al 2005;Liang et al 2001), neutrophils (Moreira et al 2007;Selloum et al 2001;Wang et al 2006), basophils (Shim et al 2009), and mast cells (Kempuraj et al 2005;Lee et al 2010). Here we reported that kaempferol attenuates DC activation for the first time.…”

Anti-inflammatory and Immunomodulatory Properties of 2-Amino-3H-phenoxazin-3-one

“…22) Briefly, spleen cells were incubated in FCS-coated plastic plates for 1.5 h at 37°C. After incubation, non-adherent cells were seeded onto goat anti-mouse Ig (DAKO, Glostrup, Denmark)-coated plates for 1 h at 4°C to remove B cells, and the recovered non-adherent cells incubated with ascites fluid containing rat anti-mouse CD4 mAb from the GK1.5 hybridoma (a gift from Dr. E. Nakayama, Okayama University Medical School, Okayama, Japan) for 30 min on ice, and then washed twice with medium.…”