The flavonoid hesperidin methyl chalcone as a potential therapeutic agent for cancer therapy: Molecular docking, in vitro cytotoxicity, and in vivo antitumor activity

Rizvi, Syed Mohd Danish; Mudagal, Manjunatha P.; Boregowda, Sateesha Shivally; Hussain, Talib; Hagbani, Turki Al; Abdallah, Marwa H.; Khafagy, El-Sayed; Hussain, Arshad; Adam, Fahad Abdelrahman Yousif; Lila, Amr S. Abu

doi:10.1016/j.arabjc.2023.104769

Cited by 5 publications

(1 citation statement)

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“…Hesperidin usually has a low solubility in water; however, this can be overcome by an alkaline methylation procedure. This process leads to the creation of HMC by promoting hesperidin's isomerization and improving its solubility (Rizvi et al 2023).…”

Section: Corrosion Inhibitormentioning

confidence: 99%

Corrosion Inhibitive Action of Hesperidin methyl chalcone (HMC) on Aluminum in H2SO4

Mohamed,

Alkorbi

2024

Preprint

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Using both theoretical and experimental techniques, the impact of Hesperidin methyl chalcone (HMC) on Aluminum corrosion in 0.5M H2SO4 was examined at various temperatures. Measurements of weight loss revealed that the inhibitory efficiency rises with rising HMC concentrations and falls with rising temperatures. An inhibitor's overall rising inhibitory efficacy is ascribed to the bulk of the solution's adsorption onto the aluminum surfaces. The Langmuir adsorption isotherm is best fitted by the adsorption process model, as well as calculated thermodynamic parameters, were spoken about. Thermodynamic characteristics show that the HMC uses a combination of physisorption and chemisorption to adsorb spontaneously onto metal surfaces and delay corrosion. The effect of temperature on Aluminum's HMC inhibition efficiency in 0.5M H2SO4 is explained by the activation parameters. The experimental results are supported by the quantum chemical parameters, which likewise show good agreement with them.

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Section: Corrosion Inhibitormentioning

confidence: 99%