The flavonoid fustin exerts anti-inflammatory effect in a model of carrageenan-induced paw oedema

Reyzov, M.; Павлов, Д. В.; Novakovic, M.; Tešević, Vele; Georgieva, Antoaneta; Eftimov, Miroslav; Todorova, M; Valcheva-Kuzmanova, Stefka

doi:10.1556/066.2022.00226

Cited by 3 publications

(2 citation statements)

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“…F5+PCM and F10+PCM animals received fustin at doses of 5 mg/kg and 10 ml/kg, respectively, as a 10 ml/kg suspension. These doses of fustin have been shown to exert anti-inflammatory and gastroprotective effects in our previous investigations [12,16].…”

Section: Experimental Animals and Treatmentmentioning

confidence: 99%

Hepatoprotective effect of the flavonoid fustin in a rat model of paracetamol-induced acute liver damage

Salbashian,

Stefanova,

Tzaneva

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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Paracetamol (PCM)-induced toxicity is a well-established pharmacological model. Cotinus coggygria is a medicinal plant rich in polyphenols, including the flavonoid fustin. The aim of the present study was to evaluate the effects of the flavonoid fustin isolated from Cotinus coggygria heartwood in a model of PCM-induced liver damage. Male Wistar rats (n=48) were allocated to four groups: Control, PCM, F5+PCM, F10+PCM. The rodents were treated daily orally for nine consecutive days as follows: groups F5+PCM and F10+PCM – with fustin (suspended in a vehicle) at doses of 5 and 10 mg/kg, respectively; groups Control and PCM – with the vehicle. PCM was injected intraperitoneally (1.0 g/kg) on day 7. At the end of the experiment, serum and liver samples were prepared. PCM caused a severe liver damage confirmed by histopathological, immunohistochemical and biochemical indices. Compared to PCM group, in F5+PCM and F10+PCM groups, the hepatic necrosis, steatosis, ballooning degeneration, inflammation and expression of NF-κB were significantly reduced. Fustin treatment resulted in a significant reduction of serum activities of alanine aminotransferase and gamma-glutamyl transferase to levels that did not differ from the control values. The present study demonstrated a hepatoprotective effect of the flavonoid fustin in a rat model of acute paracetamol-induced toxicity.

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Section: Experimental Animals and Treatmentmentioning

confidence: 99%

Hepatoprotective effect of the flavonoid fustin in a rat model of paracetamol-induced acute liver damage

Salbashian,

Stefanova,

Tzaneva

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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“…(Eurasian Smoke tree). It possesses antiinflammatory properties demonstrated in rat models of carrageenan-induced paw oedema [8] and indomethacin-induced gastric ulceration [9].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effects of the flavonoid fustin in a rat model of trinitrobenzensulfonic acid-induced colitis

Eftimov,

Georgieva,

Pavlov

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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Trinitrobenzene sulfonic acid (TNBS)-induced colitis is a widely used animal model that mimics the signs and symptoms of inflammatory bowel disease. Fustin is a flavonoid found in Cotinus coggygria. The aim of the present study was to investigate the effect of fustin isolated from Cotinus coggygria heartwood in a rat model of TNBS-induced colitis. In this experiment, 30 male Wistar rats were used, allocated to three groups: Control, TNBS and TNBS+F10. Colitis was induced by rectal application of TNBS. After the induction of colitis, fustin at a dose of 10 mg/kg was administered orally to TNBS+F10 group in the course of 8 days. Severity of colitis, oxidative stress and inflammation were assessed by macroscopic, histopathological, immunohistochemical and biochemical analyses. Rats from TNBS group demonstrated severe colonic damage. Fustin treatment ameliorated most of the macroscopic and some of the histopathological indices of colonic damage, and restored the activity of the endogenous antioxidant superoxide dismutase in tissue homogenate but did not affect the signs of inflammation measured by the activity of alkaline phosphatase in serum and tissue homogenate, as well as the expression of NF-kB in the colon. In conclusion, the ameliorative effects of fustin in the experimental TNBS-induced colitis might be the result of its antioxidant properties.

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Gastroprotective effect of the flavonoid fustin isolated from Cotinus coggygria heartwood in a rat model of indomethacin-induced gastric ulceration

Georgieva

Павлов

Tzaneva

et al. 2023

Acta Scientifica Naturalis

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Gastric ulcer is a common health issue. Cotinus coggygria heartwood extracts rich in the flavonoids fustin and sulfuretin have shown protective effects in a rat model of indomethacin-induced gastric ulceration. Fustin itself has been protective in a rat model of ethanol-induced gastric ulcer. In the present study we aimed to reveal the effect of the flavonoid fustin isolated from Cotinus coggygria heartwood in a rat model of indomethacin-induced gastric ulceration. Fustin was isolated from Cotinus coggygria heartwood and purified. The experiment was performed on 30 male Wistar rats allocated to three groups – Control, Indo and F10. F10 group was pretreated with fustin (10 mg/kg b.w. for 7 days). Rats were sacrificed and macroscopic, histopathological and immunohistochemical investigations of the stomachs were performed. Indomethacin caused severe mucosal damage, proven by the macroscopic, microscopic and immunohistochemical gastric mucosa investigation. Fustin pretreatment slightly reduced the macroscopic indices for gastric damage (ulcer number, area, score and index), and significantly alleviated the severity of the microscopic indices (mucosal erosions, necrosis, hemorrhages and inflammation). In fustin-pretreated rats, the expression of NF-κB was reduced in comparison with indomethacin-treated animals. In conclusion, fustin exerted a gastroprotective action in an indomethacin-induced gastric ulceration model, probably due to its anti-inflammatory activity.

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The flavonoid fustin exerts anti-inflammatory effect in a model of carrageenan-induced paw oedema

Cited by 3 publications

References 0 publications

Hepatoprotective effect of the flavonoid fustin in a rat model of paracetamol-induced acute liver damage

Hepatoprotective effect of the flavonoid fustin in a rat model of paracetamol-induced acute liver damage

Ameliorative effects of the flavonoid fustin in a rat model of trinitrobenzensulfonic acid-induced colitis

Gastroprotective effect of the flavonoid fustin isolated from Cotinus coggygria heartwood in a rat model of indomethacin-induced gastric ulceration

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