The five-year survival rate after endoscopic submucosal dissection for superficial esophageal squamous cell neoplasia

Nagami, Yasuaki; Ominami, Masaki; Shiba, Masatsugu; Minamino, Hiroaki; Fukunaga, Shusei; Kameda, Natsuhiko; Sugimori, Satoshi; Machida, Hirohisa; Tanigawa, Tetsuya; Yamagami, Hirokazu; Watanabe, Toshio; Tominaga, Kazunari; Fujiwara, Yasuhiro; Arakawa, Tetsuo

doi:10.1016/j.dld.2016.12.009

Cited by 60 publications

(64 citation statements)

References 32 publications

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“…Esophageal cancer has a poor prognosis, and this relates to difficulties associated with early detection . New optical imaging techniques; for example, narrow‐band imaging endoscopy, have facilitated the detection of early‐stage esophageal cancer, and curative endoscopic resection has improved survival rates . In addition, en bloc resections can be achieved for superficial esophageal neoplasias using endoscopic submucosal dissection (ESD) regardless of tumor size .…”

Section: Introductionmentioning

confidence: 99%

“…1,2 New optical imaging techniques; for example, narrow-band imaging endoscopy, have facilitated the detection of early-stage esophageal cancer, 3,4 and curative endoscopic resection has improved survival rates. [5][6][7][8] In addition, en bloc resections can be achieved for superficial esophageal neoplasias using endoscopic submucosal dissection (ESD) regardless of tumor size. [6][7][8] However, widespread resection involving over 71% of the circumferential mucosal defect by ESD has led to a high incidence of stricture formation.…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7][8] In addition, en bloc resections can be achieved for superficial esophageal neoplasias using endoscopic submucosal dissection (ESD) regardless of tumor size. [6][7][8] However, widespread resection involving over 71% of the circumferential mucosal defect by ESD has led to a high incidence of stricture formation. 9,10 Serious dietary deficiencies caused by refractory esophageal stricture formation reduce the quality of life of patients and necessitate multiple endoscopic balloon dilatation (EBD) sessions that incur high medical costs.…”

Section: Introductionmentioning

confidence: 99%

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Prediction of esophageal stricture in patients given locoregional triamcinolone injections immediately after endoscopic submucosal dissection

Nagami

Ominami

Shiba

et al. 2017

Digestive Endoscopy

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prediction of esophageal stricture in patients given locoregional triamcinolone injections immediately after endoscopic submucosal dissection

Nagami

Ominami

Shiba

et al. 2017

Digestive Endoscopy

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“…Endoscopic submucosal dissection (ESD) is an endoscopic technique for gastrointestinal neoplasms that allows the en bloc resection of entire circumferential esophageal lesions regardless of tumor size or location . Compared with endoscopic mucosal resection, esophageal ESD is considered to be more effective in enabling en bloc resections and reducing the recurrence rate . However, as esophageal ESD is more likely to cause lesions of larger size, it is of the high incidence to form post‐ESD esophageal strictures.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Compared with endoscopic mucosal resection, esophageal ESD is considered to be more effective in enabling en bloc resections and reducing the recurrence rate. 3 However, as esophageal ESD is more likely to cause lesions of larger size, it is of the high incidence to form post-ESD esophageal strictures. More particularly, postoperative stenosis occurs in all patients who underwent complete circumference resection.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of steroid in the prevention of esophageal stricture after endoscopic submucosal dissection: A network meta‐analysis

Yang

Wang

et al. 2019

J of Gastro and Hepatol

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Background and Aim Even though endoscopic submucosal dissection is an important endoscopic resection technique for gastrointestinal neoplasms, there are chances that postoperative esophageal stricture might take place as a side effect. Steroid applications were reported to be effective for the prevention of stricture formation. Therefore, this study aims to evaluate the efficacy and safety of different steroid applications. Methods Eligible studies published on PubMed, the Cochrane Library, Embase, Web of Science, and Chinese Biomedical Literature Database before August 2018 were reviewed. The preventions were divided as placebo/no treatment, long‐term oral steroid (LOS), median‐term oral steroid, short‐term oral steroid, single‐dose steroid injection, multiple‐dose steroid injection, topical superficial steroid, steroid injection combined with oral steroid, and preemptive endoscopic balloon dilatation. The primary outcomes were postoperative esophageal stricture rate and endoscopic balloon dilatation sessions required. Complications were also analyzed. Results A total of 19 studies were included. The network meta‐results illustrated that compared with the placebo, all kinds of steroid interventions were associated with lower rates of postoperative esophageal stenosis and less number of endoscopic balloon dilatation sessions. Moreover, combined therapy was no better than single regimen therapy. No significant differences between various steroid applications in the incidence of complications were spotted during this study. Based on the results of the network and clustered ranking, LOS might be the superior prevention for postoperative stricture with satisfying efficacy. Conclusion The present study showed that LOS appears to be the optimal prevention method for postoperative stricture formation.

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Endoscopic resection of esophageal squamous cell carcinoma: Current indications and treatment outcomes

et al. 2021

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Endoscopic resection (ER) is an alternate minimally invasive treatment for superficial esophageal squamous cell carcinoma (SESCC). We aimed to review the clinical indications and treatment outcomes of ER for SESCC. Endoscopic mucosal resection is relatively easy and efficient for SESCC ≤ 15 mm. In contrast, endoscopic submucosal dissection (ESD) is recommended to achieve en bloc resection for lesions >15 mm, in view of the accurate pathological evaluation. The Japan Gastroenterological Endoscopy Society guidelines recommend ER for non‐circumferential cT1a‐EP/LPM (epithelium/lamina propria mucosae), cT1a‐MM/T1b‐SM1 (muscularis mucosa/superficial submucosa ≤ 200μm) SESCC, and whole‐circumferential T1a‐EP/LPM SESCC ≤ 50 mm (upon implementing preventive measures for stenosis), considering the risk‐benefit balance of ER. It defines pT1a‐EP/LPM without lymphovascular invasion as a curative endoscopic resection. The guidelines recommend additional esophagectomy or chemoradiotherapy for pT1b SESCC or any SESCC, with lymphovascular invasion. However, there is no recommendation for or against the administration of additional treatments for pT1a‐MM without lymphovascular invasion, owing to limited evidence. Researchers have reported on high en bloc and R0 resection rates of ESD, and a randomized controlled trial demonstrated that clip‐line traction‐assisted ESD could significantly reduce the ESD procedural time. Moreover, steroid treatment has been developed to prevent post‐ESD esophageal strictures. There have been reports on favorable long‐term outcomes of ESD. However, most of them are retrospective studies. Further robust data in prospective trials are warranted to achieve a definitive evidence of ESD, which will be beneficial to patients with SESCC.

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The five-year survival rate after endoscopic submucosal dissection for superficial esophageal squamous cell neoplasia

Cited by 60 publications

References 32 publications

Prediction of esophageal stricture in patients given locoregional triamcinolone injections immediately after endoscopic submucosal dissection

Prediction of esophageal stricture in patients given locoregional triamcinolone injections immediately after endoscopic submucosal dissection

Efficacy and safety of steroid in the prevention of esophageal stricture after endoscopic submucosal dissection: A network meta‐analysis

Endoscopic resection of esophageal squamous cell carcinoma: Current indications and treatment outcomes

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