The five homologous CiaR-controlled Ccn sRNAs ofStreptococcus pneumoniaemodulate Zn-resistance
Nicholas R. De Lay,
Nidhi Verma,
Dhriti Sinha
et al.
Abstract:Zinc is a vital transition metal forStreptococcus pneumoniae, but is deadly at high concentrations. Zn intoxication ofS. pneumoniaeresults from a deficiency in Mn, which is required for key metabolic enzymes and defense against oxidative stress. Here, we report our identification and characterization of the function of the five homologous, CiaRH-regulated Ccn sRNAs in controllingS. pneumoniaevirulence and metal homeostasis. We show that deletion of all fiveccngenes (ccnA,ccnB,ccnC,ccnD, andccnE) fromS. pneumon… Show more
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