The five choice serial reaction time task: Comparison between Sprague–Dawley and Long–Evans rats on acquisition of task, and sensitivity to phencyclidine

Auclair, Agnès; Besnard, Joël; Newman‐Tancredi, Adrian; Depoortère, R.

doi:10.1016/j.pbb.2009.01.005

Cited by 28 publications

(24 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, increases in anticipatory responding only emerged after several days of PCP injection when the non-specific response suppressant effects had subsided. The differences in sensitivity to PCP between this study and the present one may partly be reflected in the rat strain differences (Wister versus LongEvans rats), and dose/route of administration of PCP employed; an explanation supported by Auclair et al (2009). The dosing regime that we employed may produce more regionally selective deficits in prefrontal circuitry (Cochran et al 2003;Morris et al 2005;Pratt et al 2008) to induce the relatively specific effects on premature responding.…”

Section: Pcp Treatment and Anticipatory (Premature) Respondingmentioning

confidence: 62%

Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine

et al. 2010

View full text Add to dashboard Cite

Acute NMDA receptor antagonism impairs inhibitory control, whereas repeated treatment produces delayed deficits in cognitive processing speed. The ability of clozapine partially to restore persistent PCP-induced deficits in processing speed and in lnBeta is consistent with clinical findings. This suggests that the enduring effects of repeated PCP treatment, combined with SDA, offers a useful, translational, approach to evaluate novel cognitive enhancers in the 5-CSRTT.

show abstract

Section: Pcp Treatment and Anticipatory (Premature) Respondingmentioning

confidence: 62%

Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine

et al. 2010

View full text Add to dashboard Cite

show abstract

“…For example, Sprague-Dawley rats have lower baseline levels of performance than do Lister hooded rats 28 . In contrast, Auclair and colleagues 50 found that Sprague-Dawley rats acquired the task faster (i.e., in fewer training sessions) than did Long-Evans rats but both groups ultimately attained the same level of performance. Strain differences have also been observed when using mice; C57BL/6 mice are more accurate and make fewer premature responses than do DBA/2 mice when the stimulus duration is shortened 51 .…”

Section: Discussionmentioning

confidence: 86%

The 5-Choice Serial Reaction Time Task: A Task of Attention and Impulse Control for Rodents

Asinof

Paine

2014

JoVE

View full text Add to dashboard Cite

This protocol describes the 5-choice serial reaction time task, which is an operant based task used to study attention and impulse control in rodents. Test day challenges, modifications to the standard task, can be used to systematically tax the neural systems controlling either attention or impulse control. Importantly, these challenges have consistent effects on behavior across laboratories in intact animals and can reveal either enhancements or deficits in cognitive function that are not apparent when rats are only tested on the standard task. The variety of behavioral measures that are collected can be used to determine if other factors (i.e., sedation, motivation deficits, locomotor impairments) are contributing to changes in performance. The versatility of the 5CSRTT is further enhanced because it is amenable to combination with pharmacological, molecular, and genetic techniques.

show abstract

“…First exposure to these drugs often leads to non-specific effects in some animals such as ataxia and head weaving which are incompatible with the performance of this task while after repeated exposures these effects subside and rats start to show the characteristic deficit in performance; decreased accuracy and increased impulsivity and compulsivity (Grottick and Higgins, 2000; Higgins et al, 2003b; Le Pen et al, 2003; Amitai et al, 2007; Auclair et al, 2009; Amitai and Markou, 2010; Smith et al, 2011). In contrast rats tested after a wash-out period from sub-chronic PCP treatment do not show any performance deficit in the 5-CSRT task.…”

Section: Nmda Receptors In the Mpfc And 5-csrt Task Performancementioning

confidence: 99%

Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task

Carli

Invernizzi

2014

Front. Neural Circuits

View full text Add to dashboard Cite

Executive functions are an emerging propriety of neuronal processing in circuits encompassing frontal cortex and other cortical and subcortical brain regions such as basal ganglia and thalamus. Glutamate serves as the major neurotrasmitter in these circuits where glutamate receptors of NMDA type play key role. Serotonin and dopamine afferents are in position to modulate intrinsic glutamate neurotransmission along these circuits and in turn to optimize circuit performance for specific aspects of executive control over behavior. In this review, we focus on the 5-choice serial reaction time task which is able to provide various measures of attention and executive control over performance in rodents and the ability of prefrontocortical and striatal serotonin 5-HT1A, 5-HT2A, and 5-HT2C as well as dopamine D1- and D2-like receptors to modulate different aspects of executive and attention disturbances induced by NMDA receptor hypofunction in the prefrontal cortex. These behavioral studies are integrated with findings from microdialysis studies. These studies illustrate the control of attention selectivity by serotonin 5-HT1A, 5-HT2A, 5-HT2C, and dopamine D1- but not D2-like receptors and a distinct contribution of these cortical and striatal serotonin and dopamine receptors to the control of different aspects of executive control over performance such as impulsivity and compulsivity. An association between NMDA antagonist-induced increase in glutamate release in the prefrontal cortex and attention is suggested. Collectively, this review highlights the functional interaction of serotonin and dopamine with NMDA dependent glutamate neurotransmission in the cortico-striatal circuitry for specific cognitive demands and may shed some light on how dysregulation of neuronal processing in these circuits may be implicated in specific neuropsychiatric disorders.

show abstract

The five choice serial reaction time task: Comparison between Sprague–Dawley and Long–Evans rats on acquisition of task, and sensitivity to phencyclidine

Cited by 28 publications

References 43 publications

Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine

Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine

The 5-Choice Serial Reaction Time Task: A Task of Attention and Impulse Control for Rodents

Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task

Contact Info

Product

Resources

About