The Fischer 344 rat as a model of presbycusis

Syka, Josef

doi:10.1016/j.heares.2009.11.003

Cited by 73 publications

(67 citation statements)

References 56 publications

(76 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Long Evans rats, with a life-span of about three years and with a relatively slowly-progressing hearing impairment with age, represent a suitable model for investigating presbycusis [40]. In contrast to the Fischer 344 strain, which is frequently used as a model of fast aging (see [41] for a review), Long-Evans rats serve as a model of relatively normal aging. Three different measures of temporal auditory resolution were used in the study: i) GDT, ii) GDDL and iii) MLR amplitude-rate function for click stimulation.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

See 1 more Smart Citation

Age-related changes in auditory temporal processing in the rat

Šuta

Rybalko

Pelánová

et al. 2011

Experimental Gerontology

Self Cite

View full text Add to dashboard Cite

ACCEPTED MANUSCRIPTABBREVIATIONS: dB SPL -dB sound pressure level, GDDL -gap duration difference limen, GDT-gap detection threshold, MLR -middle latency response ABSTRACT Presbycusis, as the deterioration of hearing ability occurring with aging, can be manifested not only in a shift of hearing thresholds, but also in a deterioration of the temporal processing of acoustical signals, which may in elderly people result in degraded speech comprehension.In this study we assessed the age-related changes in the temporal processing of acoustical signals in the auditory system of pigmented rats (Long Evans strain). The temporal resolution was investigated in young adult (3-4 months) and old (30-34 months) rats by behavioral and electrophysiological methods: the rats' ability to detect and discriminate gaps in a continuous noise was examined behaviorally, and the amplitude-rate function was assessed for the middle latency response (MLR) to clicks. A worsening of the temporal resolution with aging was observed in the results of all tests. The values of the gap detection threshold (GDT) and the gap duration difference limen (GDDL) in old rats increased about two-fold in comparison with young adult rats. The MLR to a click train in old rats exhibited a significantly faster reduction in amplitude with an increasing stimulation rate in comparison with young adult rats. None of the age-related changes in the parameters characterizing temporal resolution (GDT, GDDL and MLR to a click train) correlated with the degree of the age-related hearing loss. However, the age-related changes in MLR amplitude-rate function correlated with the age-related changes in GDDL, but not with the changes in GDT. The behavioral and electrophysiological data clearly show that aging in rats is accompanied with a pronounced deficit in the temporal processing of acoustical signals that is associated with the deteriorated function of the central auditory system.

show abstract

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…many indicators point to insufficient inhibition at both the cortical and subcortical levels of the central auditory system [41,63]. Further experiments are necessary to prove this hypothesis and eventually to identify tools to remedy this defect.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Age-related changes in auditory temporal processing in the rat

Šuta

Rybalko

Pelánová

et al. 2011

Experimental Gerontology

Self Cite

View full text Add to dashboard Cite

show abstract

“…One animal model of aging in rats demonstrated an age-related decrease in the number of SMI-32 neurons (Burianová et al 2009, Syka 2016) and inhibitory GABAergic interneurons that are associated with determining the time parameters of sounds (Syka 2016). These experiments suggest that the central auditory system is associated with a decreased capacity for inhibitory processes, which may negatively impact the ability to differentiate rapid changes in sound stimuli and to differentiate them from background noise (Syka 2016).…”

Section: Introductionmentioning

confidence: 94%

“…These experiments suggest that the central auditory system is associated with a decreased capacity for inhibitory processes, which may negatively impact the ability to differentiate rapid changes in sound stimuli and to differentiate them from background noise (Syka 2016). Interestingly, however, the same GABAergic inhibitory system and the same types of neurons have also been shown to deteriorate in Alzheimer´s disease (Morrison andHof 2002, Oyelami et al 2016).…”

Section: Introductionmentioning

confidence: 98%

Influence of age on speech intelligibility in babble noise

Černý¹,

Vokřál²,

Dlouhá³

2018

Acta Neurobiologiae Experimentalis

View full text Add to dashboard Cite

Problems with hearing aids, particularly with regard to speech intelligibility in the presence of noise, are commonly reported by older individuals in everyday practice. The main goal of this study was to measure differences in speech intelligibility between older and younger people and to establish how speech intelligibility in competitive noise differs between younger and older populations with similar hearing status. More than 400 persons were tested using the Czech Test of Sentence Intelligibility in Babble Noise and divided into younger (40-65 years) and older (66-85 years) age groups. Test performance was compared between age groups based on subgroups stratified by SRT values (speech reception threshold in word audiometry in silence). Results showed a significant correlation between older age and diminished sentence intelligibility in competitive noise. Evaluation using a nonparametric U-test showed a statistical difference between the younger and older groups in sentence intelligibility, with a speech signal presented at 65 dB sound pressure level (SPL) and competitive babble noise also presented at 65 dB SPL. Increased difficulty in the use of hearing aids in older users is related, among other things, to a reduced ability to discriminate speech not only in silence but particularly in competitive variable noise due both to their aging auditory functions and to a diminished capacity to differentiate the time factors of sounds. It is probably connected with the diminished function of inhibitory neurons.

show abstract

“…• Sprague-Dawley, Long-Evans, and Fischer rats can be used on longer-term studies as they generally present with age-related hearing loss after 12 months of age (Bielefeld et al 2005;Buckiova et al 2007;Keithley and Feldman 1982;Popelar et al 2006;Syka 2010). …”

Section: Ratmentioning

confidence: 99%

The Safety Pharmacology of Auditory Function

Abernathy

2015

Principles of Safety Pharmacology

View full text Add to dashboard Cite

Safety pharmacology satisfies a key requirement in the process of drug development. Safety pharmacology studies are required to assess the impact of a new chemical entity (NCE) or biotechnology-derived product for human use on vital systems, such as those subserving auditory function. Safety pharmacology studies accordingly are defined as those studies that investigate the potential undesirable effects of a substance on auditory functions in relation to exposure in and above the therapeutic range. Auditory safety studies should be designed with the primary objective of determining how administration of a compound influences normal hearing. If an effect on hearing is identified, then it is necessary to determine through histopathology the underlying mechanism for the observed hearing loss. Since the auditory system contains a heterogeneous mixture of structural and cellular components that are organized in a very complex and integrated manner, it is necessary to clearly identify the underlying primary mechanism or target of the new chemical entity that produced the hearing loss. This chapter will highlight major components of auditory function with regard to potential opportunities for drug interaction. Aspects of designing ototoxicity studies will be discussed with an emphasis on standards deemed necessary by the US Food and Drug Administration. Additionally, classes of ototoxic compounds and their proposed mechanisms of action are described in depth.

show abstract

The Fischer 344 rat as a model of presbycusis

Cited by 73 publications

References 56 publications

Age-related changes in auditory temporal processing in the rat

Age-related changes in auditory temporal processing in the rat

Influence of age on speech intelligibility in babble noise

The Safety Pharmacology of Auditory Function

Contact Info

Product

Resources

About