The first spectrofluorimetric protocol for sensitive quantitative analysis of bromocriptine in its pure and pharmaceutical forms: evaluation of the greenness of the method

Abstract

Bromocriptine mesylate, a dopamine D2 receptor agonist, has been quantitatively determined using a sensitive, precise, quick, and affordable spectrofluorimetric method.

Ecofriendly micellar mediated spectrofluorimetric method for ultrasensitive quantification of the antiparkinsonian drug safinamide in pharmaceutical formulation and spiked human plasma

“…The reason behind this enhancement may be attributed to the formation of ion-pair complex between SAF due to the electrostatic attraction between the positively charged amino group of the drug and the negative sulfonyl group of SDS. Micellar binding increased the intensity of SAF fluorescence by reducing free rotation and collisions with the solvent molecules 6 . However, it was observed that Tween-80 and Triton X-100 decrease the RFI, as illustrated in Fig.…”

“…The capacity of these organized media to create a suitable microenvironment capable of altering the catalytic and luminescent characteristics of analytes is widely recognized. In addition, surfactants exhibit a lower environmental and human health impact than conventional organic solvents 6 – 9 . Using sodium dodecyl sulfate (SDS) as a micellar system was particularly effective in incorporating the hydrophobic compounds into the hydrophobic portion of the surfactant micelle in the aqueous solution which greatly enhanced the sensitivity of the method 10 – 13 .…”