The First Report of Otarine Herpesvirus-1-Associated Urogenital Carcinoma in a South American Fur Seal (Arctocephalus australis)

Dagleish, Mark P.; Barrows, Michelle; Maley, Madeleine; Killick, Rowena; Finlayson, J.; Goodchild, Ralph E.; Valentine, A. R.; Saunders, Richard; Willoughby, Kim; Smith, Ken; Stidworthy, Mark F.

doi:10.1016/j.jcpa.2012.10.002

Cited by 21 publications

(11 citation statements)

References 15 publications

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“…Sexual transmission is thought to occur and females may transmit the virus to pups during birth (Browning et al 2015;Buckles et al, 2007). The virus has also been associated with a single case of genital carcinoma in a South American fur seal and detected in a Steller sea lion without evidence of neoplasia (Dagleish et al, 2013).…”

Section: Dna Virusesmentioning

confidence: 99%

Pinnipediae

Colegrove

Burek‐Huntington²,

Roe

et al. 2018

Pathology of Wildlife and Zoo Animals

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Section: Dna Virusesmentioning

confidence: 99%

Pinnipediae

Colegrove

Burek‐Huntington²,

Roe

et al. 2018

Pathology of Wildlife and Zoo Animals

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“…Within the order Carnivora , in the suborder Caniformia , herpesvirus has been described in 11 species [ 4 - 10 ], five of which belong to the superfamily Pinnipedia : three form part of the family Phocidae [harbor seal ( Phoca vitulina ) [ 11 - 14 ], Hawaiian monk seal ( Monachus schauinslandi ) [ 15 ], northern elephant seal ( Mirounga angustirostris ) [ 16 ]], and two belong to the family Otariidae [California sea lion ( Zalophus californianus ) [ 17 , 13 , 3 ] and South American fur seal ( Arctocephalus australis ) [ 18 ]]. Antibodies against phocine herpesvirus (PhHV) 1 and 2 have been detected in walruses from Alaska and Russia with high seroprevalence [189/341 (55.42%) for PhHV-1, 98/341 (28.74%) for PhHV-2, 61/341 (17.89%) for both viruses in the same sample and 115/341 (33.72%) were negative] [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

First molecular detection and characterization of herpesvirus and poxvirus in a Pacific walrus (Odobenus rosmarus divergens)

et al. 2014

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BackgroundHerpesvirus and poxvirus can infect a wide range of species: herpesvirus genetic material has been detected and amplified in five species of the superfamily Pinnipedia; poxvirus genetic material, in eight species of Pinnipedia. To date, however, genetic material of these viruses has not been detected in walrus (Odobenus rosmarus), another marine mammal of the Pinnipedia clade, even though anti-herpesvirus antibodies have been detected in these animals.Case presentationIn February 2013, a 9-year-old healthy captive female Pacific walrus died unexpectedly at L’Oceanografic (Valencia, Spain). Herpesvirus was detected in pharyngeal tonsil tissue by PCR. Phylogenetic analysis revealed that the virus belongs to the subfamily Gammaherpesvirinae. Poxvirus was also detected by PCR in skin, pre-scapular and tracheobronchial lymph nodes and tonsils. Gross lesions were not detected in any tissue, but histopathological analyses of pharyngeal tonsils and lymph nodes revealed remarkable lymphoid depletion and lymphocytolysis. Similar histopathological lesions have been previously described in bovine calves infected with an alphaherpesvirus, and in northern elephant seals infected with a gammaherpesvirus that is closely related to the herpesvirus found in this case. Intracytoplasmic eosinophilic inclusion bodies, consistent with poxviral infection, were also observed in the epithelium of the tonsilar mucosa.ConclusionTo our knowledge, this is the first molecular identification of herpesvirus and poxvirus in a walrus. Neither virus was likely to have contributed directly to the death of our animal.

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“…It is interesting to note that an OtHV-1-associated UGC has recently been reported in a South American fur seal ( Arctocephalus australis ) 27 , indicating that other pinnipeds are susceptible to UGC, and further implicating OtHV-1 as a causative agent. Furthermore, a recent analysis of cytological smears collected from California sea lions in the Gulf of California revealed that transformation of the genital epithelium may be relatively common in this species 28 .…”

Section: Discussionmentioning

confidence: 96%

No evidence for clonal transmission of urogenital carcinoma in California sea lions (Zalophus californianus)

Leathlobhair¹,

Gulland²,

Murchison³

2017

Wellcome Open Res

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Urogenital carcinoma is a highly metastatic cancer affecting California sea lions ( Zalophus californianus). The disease has high prevalence amongst stranded animals, and is one of the most commonly observed cancers in wildlife. The genital localisation of primary tumours suggests the possibility that coital transmission of an infectious agent could underlie this disease. Otarine herpesvirus type 1 has been associated with lesions, however a causative role for this virus has not been confirmed. We investigated the possibility that urogenital carcinoma might be clonally transmissible, spread by the direct transfer of cancer cells. Analysis of sequences at the mitochondrial DNA control region in seven matched tumour and host pairs confirmed that tumour genotypes were identical to those of their matched hosts and did not show similarity with tumours from other individuals. Thus our findings suggest that urogenital carcinoma in California sea lions is not clonally transmitted, but rather arises from transformed host cells.

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The First Report of Otarine Herpesvirus-1-Associated Urogenital Carcinoma in a South American Fur Seal (Arctocephalus australis)

Cited by 21 publications

References 15 publications

Pinnipediae

Pinnipediae

First molecular detection and characterization of herpesvirus and poxvirus in a Pacific walrus (Odobenus rosmarus divergens)

No evidence for clonal transmission of urogenital carcinoma in California sea lions (Zalophus californianus)

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