The first presentation of diabetes in a four-month-old infant with diabetic ketoacidosis (DKA) precipitating by COVID-19: a case report

Maleki, Elham; Baniasad, Amir; M, Sepehran; Davoudian, Najmeh

doi:10.22541/au.162927045.59295984/v1

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…Additionally, most studies are related to T1DM, and a few studies have evaluated the condition of DKA in type 2 diabetes mellitus (T2DM). On the other hand, the study on DKA during COVID-19 in Iran is limited, and there are only a few case-report studies (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Diabetic Ketoacidosis Characteristics During- and Before the COVID-19 Pandemic

Injinari

Ghoshouni

Mehrabbeik

et al. 2023

Int J Endocrinol Metab

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Background: Despite evidence about the relationship between diabetic ketoacidosis (DKA) and infectious diseases, our knowledge of DKA during the coronavirus disease 2019 (COVID-19) pandemic remains unclear. Objectives: This study aimed to compare the DKA situation among individuals with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) during the COVID-19 pandemic compared to pre-pandemic. Methods: This retrospective-longitudinal study included individuals with T1DM and T2DM hospitalized with newly diagnosed DKA before (March to August 2018 and 2019) and during (March to August 2020 and 2021) the COVID-19 pandemic. Demographics, the frequency of new-onset diabetes mellitus (DM) and new-onset DKA, days of hospitalization, DKA severity, laboratory tests, and mortality were assessed. Results: Of 162 patients with DKA, 139 patients were newly diagnosed. The frequency of individuals with new-onset DM had increased during the pandemic compared to pre-pandemic (P = 0.047). Moreover, new-onset DKA was higher in 2020 and 2021 versus 2019 and 2018 (P = 0.002). Significantly, there were no T2DM patients with DKA in pre-pandemic, but DKA admissions in people with T2DM increased in 2021 (P < 0.001). The severity of new-onset DKA had increased during the pandemic compared to pre-pandemic (P = 0.000). However, there was no significant difference between pre-and the pandemic regarding mortality (P = 0.981). Additionally, hospitalization length (P = 0.043) and mortality (P = 0.038) were higher in patients with T2DM compared to T1DM. Conclusions: During the COVID-19 pandemic, the frequency of DKA and its severity was higher than in pre-pandemic, and COVID-19 can be more life-threatening in patients with T2DM. Therefore, healthcare providers should be alert to DKA, especially in patients with T2DM.

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Section: Introductionmentioning

confidence: 99%