The first pregnant woman with COVID-19 in Venezuela: Pre-symptomatic transmission

Forero‐Peña, David A.; Rodríguez, Mariana Isabel Dos Santos; Flora-Noda, David M.; Maricuto, Andrea L.; Velásquez, Viledy L.; Soto, Lili M.; Garcia, Yoel D.; Ureña, Francisco A.; Mosqueda, Mariangela; Franco-Lugo, Rommel; Marcano, María V.; Morillo, Grismely A.; Carballo, Martín; Caldera, Jocays; Redondo, María C.; Landaeta, María Eugenia

doi:10.1016/j.tmaid.2020.101805

Cited by 6 publications

(1 citation statement)

References 6 publications

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“…Recently, it was documented a high prevalence of maternal–fetal complications in Venezuela caused mainly by P. vivax [ 29 ], traditionally described as benign. On the other hand, while the clinical behavior of patients with COVID-19 during the first wave in Venezuela showed a high overall and in-hospital mortality [ 30 ], the clinical outcome of the first locally recorded pregnant woman infected with SARS-CoV-2 and her child was favorable [ 31 ]. However, two recent studies reported a high prevalence of maternal–fetal events among Venezuelan pregnant women with COVID-19 [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Plasmodium vivax and SARS-CoV-2 co-infection in Venezuelan pregnant women: a case series

Carrión‐Nessi

Mendoza-Millán

Omaña‐Ávila

et al. 2023

Malar J

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Background Malaria‐endemic areas are not spared from the impact of coronavirus disease 2019 (COVID-19), leading to co-infection scenarios where overlapping symptoms impose serious diagnostic challenges. Current knowledge on Plasmodium spp. and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co‐infection in pregnant women remains limited, especially in Latin America, where Plasmodium vivax infection is highly prevalent. Methods This is a case series of five pregnant women with P. vivax and SARS-CoV-2 co-infection hospitalized in two main malaria referral centers of the Capital District and Bolivar state, Venezuela between March 13, 2020 and December 31, 2021. Results Clinical and laboratory data from five pregnant women with a mean age of 22 years were analyzed; three of them were in the third trimester of pregnancy. Comorbidities included obesity in two cases, hypertension in one, and asthma in one. Three out of five patients had severe to critical COVID-19 disease. Dry cough, fever, chills, and headache were the most frequent symptoms reported. Laboratory analyses showed elevated aspartate/alanine aminotransferase and creatinine levels, thrombocytopenia, and severe anemia as the most relevant abnormalities. The mean period between symptom onset and a positive molecular test for SARS-CoV-2 infection or positive microscopy for Plasmodium spp. was 4.8 ± 2.5 days and 2.8 ± 1.6 days, respectively. The mean hospital stay was 5.4 ± 7 days. Three women recovered and were discharged from the hospital. Two women died, one from cerebral malaria and one from respiratory failure. Three adverse fetal outcomes were registered, two miscarriages and one stillbirth. Conclusion This study documented a predominance of severe/critical COVID-19 disease and a high proportion of adverse maternal–fetal outcomes among pregnant women with malaria and COVID-19 co-infection. More comprehensive prospective cohort studies are warranted to explore the risk factors, management challenges, and clinical outcomes of pregnant women with this co-infection.

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Section: Discussionmentioning

confidence: 99%

Plasmodium vivax and SARS-CoV-2 co-infection in Venezuelan pregnant women: a case series

Carrión‐Nessi

Mendoza-Millán

Omaña‐Ávila

et al. 2023

Malar J

Self Cite

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Burden of stillbirths among women vaccinated with COVID-19 vaccines: A systematic review and meta-analysis

Singh,

Padhi,

Gandhi

et al. 2023

Travel Medicine and Infectious Disease

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Transmission of SARS‐CoV‐2 through breast milk and breastfeeding: a living systematic review

Centeno‐Tablante

Medina‐Rivera

Finkelstein

et al. 2020

Annals of the New York Academy of Sciences

146

123

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The pandemic of coronavirus disease 2019 (COVID-19) is caused by infection with a novel coronavirus strain, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, there is limited information on potential transmission of the infection from mother to child, particularly through breast milk and breastfeeding. Here, we provide a living systematic review to capture information that might necessitate changes in the guidance on breast milk and breastfeeding given the uncertainty in this area. Our search retrieved 19,414 total records; 605 were considered for full-text eligibility and no ongoing trials were identified. Our review includes 340 records, 37 with breast milk samples and 303 without. The 37 articles with analyzed breast milk samples reported on 77 mothers who were breastfeeding their children; among them, 19 of 77 children were confirmed COVID-19 cases based on RT-PCR assays, including 14 neonates and five older infants. Nine of the 68 analyzed breast milk samples from mothers with COVID-19 were positive for SARS-CoV-2 RNA; of the exposed infants, four were positive and two were negative for COVID-19. Currently, there is no evidence of SARS-CoV-2 transmission through breast milk. Studies are needed with longer follow-up periods that collect data on infant feeding practices and on viral presence in breast milk.

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The first pregnant woman with COVID-19 in Venezuela: Pre-symptomatic transmission

Cited by 6 publications

References 6 publications

Plasmodium vivax and SARS-CoV-2 co-infection in Venezuelan pregnant women: a case series

Plasmodium vivax and SARS-CoV-2 co-infection in Venezuelan pregnant women: a case series

Burden of stillbirths among women vaccinated with COVID-19 vaccines: A systematic review and meta-analysis

Transmission of SARS‐CoV‐2 through breast milk and breastfeeding: a living systematic review

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