The First In Vivo Study Shows That Gyrophoric Acid Changes Behavior of Healthy Laboratory Rats
Patrik Simko,
Andrea Leskanicova,
Maria Suvakova-Nunhart
et al.
Abstract:Gyrophoric acid (GA), a lichen secondary metabolite, has attracted more attention during the last years because of its potential biological effects. Until now, its effect in vivo has not yet been demonstrated. The aim of our study was to evaluate the basic physicochemical and pharmacokinetic properties of GA, which are directly associated with its biological activities. The stability of the GA in various pH was assessed by conducting repeated UV-VIS spectral measurements. Microsomal stability in rat liver micr… Show more
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