The first in vivo application of synthetic polymers based on methacrylic acid as an aflatoxin sorbent in an animal model

Arak, Homa; Torshizi, Mohammad Amir Karimi; Hedayati, Mehdi; Rahimi, Shaban

doi:10.1007/s12550-019-00353-z

Cited by 5 publications

(6 citation statements)

References 53 publications

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“…It should be noted that mycotoxins can be included in bird droppings not only in free form, but also in the matrix of sorbents that enter the litter in different ways [ 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ]. Bird droppings almost always contain sorbents, since they are used as a feed additive, introduced into the litter for sorption of droppings together with excess moisture to reduce the growth rate of mycelial fungi [ 47 ].…”

Section: Mycotoxins In Poultry Manurementioning

confidence: 99%

Destruction of Mycotoxins in Poultry Waste under Anaerobic Conditions within Methanogenesis Catalyzed by Artificial Microbial Consortia

Ефременко

Senko

Maslova

et al. 2023

Toxins

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To reduce the toxicity of modern feeds polluted by mycotoxins, various sorbents are added to them when feeding animals. A part of the mycotoxins is excreted from the body of animals with these sorbents and remains in the manure. As a result, bulk animal wastes containing mixtures of mycotoxins are formed. It is known that it is partially possible to decrease the initial concentration of mycotoxins in the process of anaerobic digestion (AD) of contaminated methanogenic substrates. The aim of this review was to analyze the recent results in destruction of mycotoxins under the action of enzymes present in cells of anaerobic consortia catalyzing methanogenesis of wastes. The possible improvement of the functioning of the anaerobic artificial consortia during detoxification of mycotoxins in the bird droppings is discussed. Particular attention was paid to the possibility of effective functioning of microbial enzymes that catalyze the detoxification of mycotoxins, both at the stage of preparation of poultry manure for methanogenesis and directly in the anaerobic process itself. The sorbents with mycotoxins which appeared in the poultry wastes composed one of the topics of interest in this review. The preliminary alkaline treatment of poultry excreta before processing in AD was considered from the standpoint of effectively reducing the concentrations of mycotoxins in the waste.

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Section: Mycotoxins In Poultry Manurementioning

confidence: 99%

Destruction of Mycotoxins in Poultry Waste under Anaerobic Conditions within Methanogenesis Catalyzed by Artificial Microbial Consortia

Ефременко

Senko

Maslova

et al. 2023

Toxins

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“…Many synthetic polymers, such as cholestyramine, divinylbenzene-styrene, and polyvinylpyrrolidone, have been shown to bind mycotoxins effectively [138]. More recently, Arak et al (2019) have synthesized polymers based on methacrylic acid, and a macroporous molecularly imprinted polymer, TMU95, was efficient in binding AFB1 in the feed of ducklings. It also had beneficial effects on the growth of the livestock and alleviated the harmful physiological effects of the mycotoxin [139].…”

Section: Agents Detoxifying Afs In Animal Husbandrymentioning

confidence: 99%

“…More recently, Arak et al (2019) have synthesized polymers based on methacrylic acid, and a macroporous molecularly imprinted polymer, TMU95, was efficient in binding AFB1 in the feed of ducklings. It also had beneficial effects on the growth of the livestock and alleviated the harmful physiological effects of the mycotoxin [139]. A new adsorbent was developed for the selective removal of AFM1 content of raw milk using a molecularly imprinted polymer, which is coated on the surface of the stainless-steel plate [140].…”

Section: Agents Detoxifying Afs In Animal Husbandrymentioning

confidence: 99%

Physical and Chemical Methods for Reduction in Aflatoxin Content of Feed and Food

Sípos

Peles

Brassó

et al. 2021

Toxins

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Aflatoxins (AFs) are among the most harmful fungal secondary metabolites imposing serious health risks on both household animals and humans. The more frequent occurrence of aflatoxins in the feed and food chain is clearly foreseeable as a consequence of the extreme weather conditions recorded most recently worldwide. Furthermore, production parameters, such as unadjusted variety use and improper cultural practices, can also increase the incidence of contamination. In current aflatoxin control measures, emphasis is put on prevention including a plethora of pre-harvest methods, introduced to control Aspergillus infestations and to avoid the deleterious effects of aflatoxins on public health. Nevertheless, the continuous evaluation and improvement of post-harvest methods to combat these hazardous secondary metabolites are also required. Already in-use and emerging physical methods, such as pulsed electric fields and other nonthermal treatments as well as interventions with chemical agents such as acids, enzymes, gases, and absorbents in animal husbandry have been demonstrated as effective in reducing mycotoxins in feed and food. Although most of them have no disadvantageous effect either on nutritional properties or food safety, further research is needed to ensure the expected efficacy. Nevertheless, we can envisage the rapid spread of these easy-to-use, cost-effective, and safe post-harvest tools during storage and food processing.

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“…Search for new binders is warranted by the predictable increase of the aflatoxin issue elicited by climate changes. These include natural clays and ashes from developing countries ( 43 ), yeast wall components ( 42 , 54 ), agricultural by-products ( 40 , 55 ), molecularly imprinted polymers ( 41 ) and nanomaterials ( 56 ). In particular, nanomaterials may operate through different modes of actions either by inhibiting the mold growth, mycotoxin adsorption, and also by reducing the toxic effect ( 57 ).…”

Section: Case Study 2: Aflatoxin Binders For Dairy Ruminantsmentioning

confidence: 99%

“…A reduced bioaccessibility in vitro or a reduced AFM1 excretion in cows exposed to feed with AF contamination above the legal limit can only provide supportive evidence (10). Surely, since the efficacy, and hence the health benefit, of mycotoxin binders must be assessed case-by-case, in vitro screening methods are of use, such as adsorption assays simulating physiological pH values (40)(41)(42)(43) or more complex models mimicking the rumen environment (44). From the -often overlooked -standpoint of safety, it is important to screen the interaction between mycotoxin binders and veterinary drugs with respect to the potential non-specific binding of drugs (45).…”

Section: Rbamentioning

confidence: 99%

Risk-Benefit Assessment of Feed Additives in the One Health Perspective

et al. 2022

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Safety and sustainability of animal feeds is a pillar of the safety of the entire food chain. Feed additive assessment incorporates consumer safety as well as animal health and welfare, which, in turn, can affect productivity and hence food security. The safety of feed users and the environment are other important components of the assessment process which, therefore, builds on a One Health perspective. In several instances the assessment entails a balanced assessment of benefits and risks for humans, animals and/or the environment. Three case studies are selected to discuss issues for a consistent framework on Risk-Benefit Assessment (RBA) of feed additives, based on EFSA opinions and literature: (a) Supplementation of feeds with trace elements with recognized human toxicity (cobalt, iodine) - RBA question: can use levels, hence human exposure, be reduced without increasing the risk of deficiency in animals?; (b) Aflatoxin binders in dairy animals - RBA question: can the use reduce the risk for human health due to aflatoxin M1, without unexpected adverse effects for animals or humans?; (c) Use of formaldehyde as preservative in feedstuffs to prevent microbial contamination - RBA question: is the reduction of microbiological risks outweighed by risks for the consumers, farmed animals or the workers? The case studies indicate that the safety of use of feed additives can involve RBA considerations which fit into a One Health perspective. As in other RBA circumstances, the main issues are defining the question and finding “metrics” that allow a R/B comparison; in the case of feed additives, R and B may concern different species (farm animals and humans). A robust assessment of animal requirements, together with sustainability considerations, might be a significant driving force for a RBA leading to a safe and effective use.

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The first in vivo application of synthetic polymers based on methacrylic acid as an aflatoxin sorbent in an animal model

Cited by 5 publications

References 53 publications

Destruction of Mycotoxins in Poultry Waste under Anaerobic Conditions within Methanogenesis Catalyzed by Artificial Microbial Consortia

Destruction of Mycotoxins in Poultry Waste under Anaerobic Conditions within Methanogenesis Catalyzed by Artificial Microbial Consortia

Physical and Chemical Methods for Reduction in Aflatoxin Content of Feed and Food

Risk-Benefit Assessment of Feed Additives in the One Health Perspective

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