The first experience of using of99mTc-Al2O3for detection of sentinel lymph nodes in breast cancer

Дорошенко, А. В.; Чернов, В. И.; Медведева, А. А.; Zelchan, Roman; Slonimskaya, Е. М.; Варламова, Н. В.; Скуридин, В. С.; Дергилев, А. П.; Синилкин, И. Г.

doi:10.1088/1757-899x/135/1/012011

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…В 2016 г. в Томском политехническом университете в рамках проекта N 16.N08.12.1011 «Доклинические исследования нового лимфотропного радиофармацевтического препарата на основе меченного технецием-99m гамма-оксида алюминия» (ФЦП «Развитие фармацевтической и медицинской промышленности Российской Федерации на период до 2020 г. и дальнейшую перспективу») был разработан оригинальный РФП на основе меченного технецием-99m гаммаоксида алюминия ( 99m Тс-Al 2 O 3 ) с размером частиц 52-77 нм. В клиническом исследовании было доказано, что 99m Тс-Al 2 O 3 активно накапливается (по сравнению с зарубежными аналогами до 12 %) в СЛУ и может быть применен с целью их определения [20].…”

Section: радиоизотопный методunclassified

Methods for Sentinel Lymph Node Detection in Patients With Breast Cancer

Зикиряходжаев

Грушина²,

Старкова³

et al. 2020

Sib. onkol. ž.

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Objective: to provide various methods for sentinel lymph node detection considering their advantages and disadvantages.Material and Methods. The search of the relevant articles published in Pubmed, MedLine, RINTs, etc. database was conducted. 49 publications from 1970 to 2018 were analyzed.Results. Currently, sentinel lymph node biopsy (SLN biopsy) has become a worthy alternative to traditional lymphatic surgery for early breast cancer. SLN biopsy significantly decreases the number of postoperative complications caused by lymphadenectomy and improves the quality of life of cancer patients. So far, a large number of SLN detection techniques have accumulated. Each of these techniques has its own advantages and disadvantages.Conclusion. Despite a large number of SLN detection methods, the question of the optimal technique is currently debatable.

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Section: радиоизотопный методunclassified

Methods for Sentinel Lymph Node Detection in Patients With Breast Cancer

Зикиряходжаев

Грушина²,

Старкова³

et al. 2020

Sib. onkol. ž.

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Trace impurities analysis of aluminum nanopowder and its air combustion product

Kabanov¹,

Merkulov²,

Mostovshchikov³

et al. 2018

AIP Conference Proceedings

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Study of Pharmacokinetics of a New Radiopharmaceutical on the Basis of Technetium-99m Labeled Glucose

Zelchan¹,

Синилкин²,

Медведева³

et al. 2019

Medical Radiology and Radiation Safety

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Purpose: To study the features of the distribution and removal of a new radiopharmaceutical (RPH) on the basis of a labeled 99mTc glucose derivative for radionuclide diagnostics of oncological diseases in the body of experimental animals. Material and methods: The main stage of the study was performed on 65 mature conventional outbred white rats and 9 rabbits of the Soviet Chinchilla breed. To study the dynamics of changes in the concentration of the studied RPH in the blood plasma and its distribution in the main organs and tissues, as well as to study the metabolic features of the drug and its excretion, the RPH studied was administered intravenously, once in activity of 20 MBq. Multiple introduction of the RPH was performed in order to study the cumulative properties of the study drug, and to elucidate the possibilities of predicting the cumulation processes from the data obtained with a single administration of RPH. For this purpose, intravenous RPH was administered at the same time 1 time / day for 5 days, at a dose of 20 MBq. To confirm the theory of linearity of the pharmacokinetics of the RFP studied, three groups of laboratory animals received the drug in three activity levels – 10, 20 and 40 MBq were used. After euthanasia, the animals were autopsied and removed the necessary organs and tissues. The prepared and washed organs were placed in tubes for further radiometry in order to study the concentrations of the RPH in the bioassay. Results: It has been established that the RPH being studied practically does not accumulate in the main organs and tissues, accumulating mainly in the kidneys and bladder. The main organs of elimination of the test drug are the kidneys, and the main excreta are urine. The half-life of the drug from the blood was 10 minutes. Pharmacokinetics of the drug is linear and does not depend on the administered activity, and the drug itself does not possess cumulative properties. Conclusion: A study of the pharmacokinetics of the RPH 99mTc-1-Thio-D-glucose showed that the preparation possesses optimal properties for the diagnostic agent. The drug stably does not accumulate in the main organs and tissues, which allows it to be reused, for example at the stages of dynamic observation of cancer patients.

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The first experience of using of^99mTc-Al₂O₃for detection of sentinel lymph nodes in breast cancer

Cited by 4 publications

References 4 publications

Methods for Sentinel Lymph Node Detection in Patients With Breast Cancer

Methods for Sentinel Lymph Node Detection in Patients With Breast Cancer

Trace impurities analysis of aluminum nanopowder and its air combustion product

Study of Pharmacokinetics of a New Radiopharmaceutical on the Basis of Technetium-99m Labeled Glucose

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