The first evidence of zoonotic hepatitis E virus (HEV) exposure in domestic cats in Türkiye

Çağırgan, Abdurrahman Anıl; Yıldırım, Yakup; Okulmus, Caglar

doi:10.1016/j.cimid.2022.101820

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…The HEV seroprevalence observed in Switzerland (38.0%) [56] and Germany (56.5%) [57], however, was significantly higher than what we observed. The seroprevalence found in our cats was 17.7%, which is approximately at a mean level compared to the results of other European countries: Spain (2.8%) [24], and (37.0%) [58]; Italy (3.1%) [59]; Turkey (5.4%) [60]; Netherlands (14.8%) [53]; and Germany (32.3%) [57]. Although it is difficult to make a comparison between different studies due to the use of different serological tests and a difference in the number of animals studied, we can state that the seroprevalence of HEV in cats and dogs in Bulgaria should be considered moderate.…”

Section: Discussionsupporting

confidence: 50%

“…Italian researchers found 0.0% (<2 years old) HEV seropositivity in household cats; 4.4% in cats aged 2–8 years, 4.6% in cats aged 9–14 years, 0.0% in cats >14 years or of an undetermined age [ 59 ]. Cagirgan et al reported 3.2% HEV positivity in domestic cats (0–2 age group); 1.09% in cats of the 2–8 age group, and 1.09% in those older than 8 years [ 60 ]. Our overall HEV seropositivity in dogs (21.1%) and cats (17.7%) is similar to that of Li et al from the Netherlands, who reported 18.5% among dogs and 14.8% in cats [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

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First Insight into the Seroepidemiology of Hepatitis E Virus (HEV) in Dogs, Cats, Horses, Cattle, Sheep, and Goats from Bulgaria

Tsachev,

Gospodinova,

Pepovich

et al. 2023

Viruses

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In recent years, hepatitis E virus (HEV) infection has been found to be widespread among different animal species worldwide. In Bulgaria, high HEV seropositivity was found among pigs (60.3%), wild boars (40.8%), and East Balkan swine (82.5%). The aim of the present study was to establish the seroprevalence of HEV among dogs, cats, horses, cattle, sheep, and goats in Bulgaria. In total, 720 serum samples from six animal species were randomly collected: dogs—90 samples; cats—90; horses—180; cattle—180; sheep—90; and goats—90. The serum samples were collected from seven districts of the country: Burgas, Kardzhali, Pazardzhik, Plovdiv, Sliven, Smolyan, and Stara Zagora. The animal serum samples were tested for HEV antibodies using the commercial Wantai HEV-Ab ELISA kit (Beijing, China). The overall HEV seroprevalence among different animal species from Bulgaria was as follows: dogs—21.1%; cats—17.7%; horses—8.3%; cattle—7.7%; sheep—32.2%; and goats—24.4%. We found the lowest overall HEV seropositivity in Plovdiv district (6.2%; 4/64; p = 0.203) and Smolyan district (8.8%; 4/45; p = 0.129), vs. the highest in Pazardzhik district (21.6%; 29/134; p = 0.024) and Burgas district (28.8%; 26/90; p = 0.062). To the best of our knowledge, this is the first serological evidence of HEV infection in dogs, cats, horses, cattle, sheep, and goats from Bulgaria. We found high HEV seropositivity in small ruminants (sheep and goats), moderate seropositivity in pets (dogs and cats), and a low level of seropositivity in large animals (horses and cattle). Previous Bulgarian studies and the results of this research show that HEV infection is widespread among animals in our country. In this regard, the Bulgarian health authorities must carry out increased surveillance and control of HEV infection among animals in Bulgaria.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

First Insight into the Seroepidemiology of Hepatitis E Virus (HEV) in Dogs, Cats, Horses, Cattle, Sheep, and Goats from Bulgaria

Tsachev,

Gospodinova,

Pepovich

et al. 2023

Viruses

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“…In Italy, 3.1% of the tested household cats were HEV-seropositive [106]. Similarly, 5.4% of the tested cats in Turkey were positive for anti-HEV antibodies [107]. However, HEV RNA was not detected in the tested cats in several previous reports [90,[105][106][107].…”

Section: Catmentioning

confidence: 74%

“…Similarly, 5.4% of the tested cats in Turkey were positive for anti-HEV antibodies [107]. However, HEV RNA was not detected in the tested cats in several previous reports [90,[105][106][107]. In Spain, a high seroprevalence (18.2%) was recorded in free-ranging and captive Iberian lynx (Lynx pardinus) and the captive cats were more seropositive than the free-ranging ones [108].…”

Section: Catmentioning

confidence: 74%

Is Hepatitis E Virus a Neglected or Emerging Pathogen in Egypt?

Sayed

Abdelwahab

2022

Pathogens

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Though Egypt ranks among the top countries for viral hepatitis and death-related liver disease, Hepatitis E virus (HEV) is a neglected disease. Living in villages and rural communities with low sanitation, use of underground well water and contact with animals are the main risk factors for HEV infection. Domestic animals, especially ruminants and their edible products, are one source of infection. Contamination of water by either human or animal stools is the main route of infection. In addition, HEV either alone or in coinfection with other hepatotropic viruses has been recorded in Egyptian blood donors. HEV seropositivity among Egyptian villagers was 60–80%, especially in the first decade of life. Though HEV seropositivity is the highest among Egyptians, HEV infection is not routinely diagnosed in Egyptian hospitals. The initial manifestations of HEV among Egyptians is a subclinical infection, although progression to fulminant hepatic failure has been recorded. With the improvement in serological and molecular approaches and increasing research on HEV, it is becoming clear that HEV represents a threat for Egyptians and preventive measures should be considered to reduce the infection rate and possible complications.

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No evidence of hepatitis E virus (HEV) infection among pet cats and dogs, and low seroprevalence of hepatitis E virus among pet rabbits in Poland

Turlewicz-Podbielska,

Ruszkowski,

Wojciechowski

et al. 2023

Vet Res Commun

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The seroprevalence of Paslahepevirus balayani genotype 3 (hepatitis E virus genotype 3 – HEV-3; Hepeviridae family, genus Paslahepevirus) in pet cats, dogs and rabbits was evaluated. Samples from cats and dogs were collected from three veterinary practices from various parts of Poland: Poznan (wielkopolskie voivodeship), Przemysl (podkarpackie voivodeship) and Lublin (lubelskie voivodeship). Samples from rabbits were collected in Poznan. In total, serum samples from 90 cats, 82 dogs and 71 rabbits were selected and tested for specific anti-HEV-3 immunoglobulin (IgG) antibodies using a commercial ELISA test. Pathogen seroprevalence among rabbits was calculated at a 95% confidence interval (CI) for each gender, age (up to 12 months, 1–3 years, 4–7 years and over 8 years), symptoms group (healthy, gastrointestinal disorders, other disorders) and compared with a chi-squared test. No anti-HEV-3 IgG antibodies were detected in any of the samples from cats and dogs. Anti-HEV-3 IgG antibodies were detected in 2.82% of the serum samples from rabbits (2/71; 95% CI: 0.78–9.70). No significant correlations between seropositivity and gender, age, and symptoms (p > 0.05) were observed in rabbits. Our findings indicate that pet rabbits in Poland are exposed to HEV-3, develop humoral response due to infection and might constitute a source for HEV-3 transmission to humans.

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The first evidence of zoonotic hepatitis E virus (HEV) exposure in domestic cats in Türkiye

Cited by 4 publications

References 35 publications

First Insight into the Seroepidemiology of Hepatitis E Virus (HEV) in Dogs, Cats, Horses, Cattle, Sheep, and Goats from Bulgaria

First Insight into the Seroepidemiology of Hepatitis E Virus (HEV) in Dogs, Cats, Horses, Cattle, Sheep, and Goats from Bulgaria

Is Hepatitis E Virus a Neglected or Emerging Pathogen in Egypt?

No evidence of hepatitis E virus (HEV) infection among pet cats and dogs, and low seroprevalence of hepatitis E virus among pet rabbits in Poland

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