The first ESR spin-trapping evidence for the formation of hydroxyl radical from the reaction of copper(II) complex with hydrogen peroxide in aqueous solution

Products of Cu(II)-catalyzed oxidation in the presence of hydrogen peroxide of the 1–10, 1–16 fragments of human and mouse β-amyloid peptide

“…It is assumed that H 2 O 2 reduces peptide-Cu 2þ to peptide-Cu þ , this is followed by the reaction of Cu þ with H 2 O 2 to give OH Å [44,45]. MCO of proteins is mainly a site-specific process in which only one or a few amino acids at metal-binding sites on the protein are preferentially oxidized [1,40,42,46,47].…”

Formation of hydroxyl radical (·OH) in illuminated surface waters contaminated with acidic mine drainage

“…A recent study [14] [16,17]. Hydroxyl radical is also formed by sunlight photolysis of hydrogen peroxide [18].…”

Products of Cu(II)-catalyzed oxidation of the N-terminal fragments of α-synuclein in the presence of hydrogen peroxide

“…For the Cu(II) complexes with peptides the generation of hydroxyl radicals was observed [27]. It is assumed that hydrogen peroxide reduces peptide-Cu(II) to peptide-Cu(I), this is followed by the reaction of Cu(I) with hydrogen peroxide to give Å OH [28]. However, it should be mentioned that the study clearly demonstrates that the mechanism of the Fenton reaction and Fenton-like reactions, in aerated solutions containing organic substrates, is considerable more complex than assumed earlier [29,30].…”