The First Epidemic of Dengue Hemorrhagic Fever in the People's Republic of China

Qiu, Fu‐Xi; Chen, Qiu-Qian; Ho, Qi-Ya; Wen-Zhou, Chen; Zhao, Zhiguo; Zhao, Bi-Wei

doi:10.4269/ajtmh.1991.44.364

Cited by 36 publications

(29 citation statements)

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“…In some studies, risk for DHF was associated with the DEN-1/DEN-2 infection sequence whereas in others it was the DEN-3/DEN-2 sequence [Sangkawibha et al, 1984;Burke et al, 1988;Hayes et al, 1988 ;Kouri et al, 1989;Guzman et al, 1990;Qiu et al, 1991].…”

Section: Discussionmentioning

confidence: 99%

Prospective study of the duration and magnitude of viraemia in children hospitalised during the 1996-1997 dengue-2 outbreak in French Polynesia

et al. 2000

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The magnitude and duration of viraemia in children admitted to the hospital with dengue was studied during a dengue 2 outbreak in French Polynesia in 1996-1997. Forty-nine patients from whom at least 3 plasma samples were available were included in the study. Based on analysis of IgG-ELISA and haemagglutination inhibition assay, 21 of these were primary and 28 were secondary infections. According to World Health Organization criteria, 42 were dengue fever and 7 were dengue haemorrhagic fever. Virus was detectable by reverse transcription-PCR in all patients for at least the first 3 days of the onset of fever, but was never detected after the 6th day (mean duration = 4.4 days). Plasma virus titers ranged from 1.7-5.6 Log(10) TCID(50)/ml. A significant difference was not observed in the magnitude and duration of viraemia in patients with primary versus secondary infections. The severity of the illness, however, was correlated with both criteria.

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Section: Discussionmentioning

confidence: 99%

Prospective study of the duration and magnitude of viraemia in children hospitalised during the 1996-1997 dengue-2 outbreak in French Polynesia

et al. 2000

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“…The first dengue case was reported as early as 1978 in China. 33,34 One of the most serious outbreaks took place in Hainan Island, and a total of 437,468 cases were reported with a morbidity level of 8,097/100,000 populations in 1980. 35 This shows that it is very important to establish a specific, sensitive, and rapid assay for the detection of DEN virus and to differentiate DEN from other viruses.…”

Section: Discussionmentioning

confidence: 99%

Rapid Identification of Chikungunya and Dengue Virus by a Real-Time Reverse Transcription-Loop-Mediated Isothermal Amplification Method

Lü

Li²,

Mo³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Both Chikungunya and Dengue virus belong to the acute arthropod-borne viruses. Because of the lack of specific symptoms, it is difficult to distinguish the two infections based on clinical manifestations. To identify and quantitatively detect Chikungunya and Dengue viruses, a real-time accelerated reverse-transcription-loop-mediated isothermal amplification (RT-LAMP) platform was developed, and 26-confirmed RNA samples, 42 suspects, and 18 healthy serum samples were evaluated by the method. The RT-polymerase chain reaction (PCR) and cDNA sequencing were used as references. The results showed that it could identify the Chikungunya and Dengue virus RNA correctly in all antibody-positive samples within 1 hour, without any cross-reactions. The virus load of the positive samples was quantitatively detected with a turbidimeter. The sensitivity was 100% and specificity was 95.25%. The findings indicate that the RT-LAMP is an effective method for rapid quantity detection of Chikungunya virus and Dengue virus in serum samples with convenient operation, high specificity, and high sensitivity.

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“…Thus, it is believed that the DF/ DHF outbreaks in Guangdong were caused mainly by cases imported from Southeast Asian countries around the time of the epidemics in Guangdong [3][4][5][6][7][8][9][10]14]. For example, the DF outbreak in Guangzhou, 2002, may have been caused by a case entering the province from Indonesia (Fig.…”

Section: Discussionmentioning

confidence: 98%

Molecular characterization of the E gene of dengue virus type 1 isolated in Guangdong province, China, in 2006

Zheng¹,

Zhou²,

Yan³

et al. 2008

Epidemiol. Infect.

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We determined the genetic relationships and origin of the dengue virus (DENV) responsible for an outbreak of dengue fever (DF) in Guangdong province, China, in 2006. Five DENV type 1 (DENV-1) isolates were obtained from human serum samples collected from DF patients during the outbreak. The nucleotide sequences of the E (envelope) gene were compared with those of 48 previous DENV-1 isolates: 18 from Guangdong province, one from Fujian province, one from Zhejiang province, and 28 from other countries in the South Asian region. The results suggested that four DENV-1 isolates identified in Guangdong province in 2006 might be in general circulation there, although these DENV-1 viruses may have been originally introduced into the province from other countries. In contrast, one isolate from Guangzhou city in 2006, may have been introduced by a recently imported case from Cambodia.

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The First Epidemic of Dengue Hemorrhagic Fever in the People's Republic of China

Cited by 36 publications

References 0 publications

Prospective study of the duration and magnitude of viraemia in children hospitalised during the 1996-1997 dengue-2 outbreak in French Polynesia

Prospective study of the duration and magnitude of viraemia in children hospitalised during the 1996-1997 dengue-2 outbreak in French Polynesia

Rapid Identification of Chikungunya and Dengue Virus by a Real-Time Reverse Transcription-Loop-Mediated Isothermal Amplification Method

Molecular characterization of the E gene of dengue virus type 1 isolated in Guangdong province, China, in 2006

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