The first draft reference genome of the American mink (Neovison vison)

Cai, Zexi; Petersen, Bent; Sahana, Goutam; Madsen, Lone Bruhn; Larsen, Knud; Thomsen, Bo; Berthou, Christian; Lund, Mogens Sandø; Guldbrandtsen, Bernt; Panitz, Frank

doi:10.1038/s41598-017-15169-z

Cited by 19 publications

(25 citation statements)

References 76 publications

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“…The number of sites for each individual and average read depth for each individual are presented in Additional file 1 : Table S1. The mink genome assembly has 7175 scaffolds [ 9 ]. Of these, 945 contained at least one SNP.…”

Section: Resultsmentioning

confidence: 99%

“… Base positions refer to the mink reference genome [ 9 ]. SNP effects are given as unsigned allele substitution effects in gram …”

Section: Resultsmentioning

confidence: 99%

“…However, without information on sequences of flanking markers from a reference genome, the usability of these markers remains impeded. Recently, Cai et al published the first draft mink genome assembly [ 9 ], which made it possible to identify SNPs across the mink genome [ 10 ] using genotyping-by-sequencing (GBS) [ 11 ]. GBS takes advantages of next-generation sequencing (NGS) technology to achieve low cost and high throughput genotyping.…”

Section: Introductionmentioning

confidence: 99%

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SNP markers associated with body size and pelt length in American mink (Neovison vison)

et al. 2018

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BackgroundIdentification of genes underlying production traits is a key aim of the mink research community. Recent availability of genomic tools have opened the possibility for faster genetic progress in mink breeding. Availability of mink genome assembly allows genome-wide association studies in mink.ResultsIn this study, we used genotyping-by-sequencing to obtain single nucleotide polymorphism (SNP) genotypes of 2496 mink. After multiple rounds of filtering, we retained 28,336 high quality SNPs and 2352 individuals for a genome-wide association study (GWAS). We performed the first GWAS for body weight, behavior, along with 10 traits related to fur quality in mink.ConclusionsCombining association results with existing functional information of genes and mammalian phenotype databases, we proposed WWC3, MAP2K4, SLC7A1 and USP22 as candidate genes for body weight and pelt length in mink.Electronic supplementary materialThe online version of this article (10.1186/s12863-018-0688-6) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

“… Base positions refer to the mink reference genome [ 9 ]. SNP effects are given as unsigned allele substitution effects in gram …”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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SNP markers associated with body size and pelt length in American mink (Neovison vison)

et al. 2018

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“…Nevertheless, further heritability estimation of growth curve parameters and their genetic correlations with other economically important traits could be useful for future implementation of genetic/genomic selection for improvement of body shape (weight and/or length) based on growth curve parameters. Moreover, the genetic mapping in mink is necessary to better understand the biology underlying growth traits to increase the accuracy of genomic prediction if applied [39][40][41]. In this study, Richards model was suggested for modelling growth in mink but it might be required to be validated in other farms with more records before implementing in the future genetic or genomic selection programs.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Growth Curve Models for Body Weight in American Mink

Ngoc

Miar

2019

Animals

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Simple Summary: Understanding the animal growth is important for optimized management and feeding practices as well as genetic improvement of animals; however, little is known about the growth of mink raised in Canada. This study evaluated the performances of ten models to find the best models describing the growth curves in mink. The results showed that Logistic and Richards were the best model for males and females, respectively. Growth curves were different between males and females. These results suggested that Richards model can be used for modelling the mink growth and modelling might be performed separately for male and female individuals.Abstract: Modelling the growth curves of animals is important for optimizing the management and efficiency of animal production; however, little is known about the growth curves in American mink (Neovison vison). The study evaluated the performances of four three-parameter (Logistic, Gompertz, von Bertalanffy, and Brody), four four-parameter (Richards, Weibull, Bridges, and Janoscheck) and two polynomial models for describing the growth curves in mink. Body weights were collected from the third week of life to the week 31 in 738 black mink (373 males and 365 females). Models were fitted using the nls and nlsLM functions in stats and minpack.lm packages in R software, respectively. The Akaike's information criterion (AIC) and Bayesian information criterion (BIC) were used for model comparison. Based on these criteria, Logistic and Richards were the best models for males and females, respectively. Four-parameter models had better performance compared to the other models except for Logistic model. The estimated maximum weight and mature growth rate varied among the models and differed between males and females. The results indicated that males and females had different growth curves as males grew faster and reached to the maximum body weight later compared to females. Further studies on genetic parameters and selection response for growth curve parameters are required for development of selection programs based on the shape of growth curves in mink.

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“…The American mink (Neovison vison), which is a semiaquatic species of mustelid [18], is the most common farmed animal for fur, exceeding the silver fox, sable, marten, and skunk in economic importance. Minks are known to be susceptible to SIB, which seriously hinders the development of the fur industry of minks.…”

Section: Introductionmentioning

confidence: 99%

A mink (Neovison vison) model of self injury: effects of CBP-CREB axis on nerve injury and behavior

Liu

Guo

et al. 2020

Preprint

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BackgroundSelf-injurious behavior (SIB) is a clinically challenging problem within both the general population and several clinical disorders. However, the precise molecular mechanism of SIB is still confused, and few animal models exist. Here, we systematic investigated the genesis and development of SIB based on behavioral and pathophysiology study in mink (Neovison vison) models.MethodWe used night-vision video to observe the mink behavior for four weeks,HE stain was performed to characteristic the pathology change of brain. We performed IHC assay to detect the protein level of Iba-1、p-CREB 、CBP and p300 in the brain tissues. Elisa assay used to examined the levels of NfL and NfH in serum and CSF of mink. qRT-PCR assay was mused to detected the expression of Bcl2, NOR1, FoxO4、c-FOS、CBP and p300 in brain tissues. Western blot was used to detect the protein levels of p-CREB、CBP and p300 in brain tissues. We also used Evans Blue as a tracer to detect whether the blood brain barrier was impaired in the brain of mink.RusultFirst we combine behavioral testing, histopathological and molecular biology experiments found that CBP was related with SIB. Mechanism analysis showed that the dysregulation of CBP in brain activated CREB signaling, resulting in nerve damage of brain and SIB symptoms in minks. Importantly, the CBP-CREB interaction inhibitor helped to relieve SIB and nerve damage in brain tissues.ConclusionOur results illustrate an induction of CBP and an activation of CREB, as a novel mechanism in the genesis of SIB. These finding indicate that CBP-CREB axis is critical for SIB and demonstrate the efficacy of the CBP-CREB interaction inhibitor in treating these behaviors.

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The first draft reference genome of the American mink (Neovison vison)

Cited by 19 publications

References 76 publications

SNP markers associated with body size and pelt length in American mink (Neovison vison)

SNP markers associated with body size and pelt length in American mink (Neovison vison)

Evaluation of Growth Curve Models for Body Weight in American Mink

A mink (Neovison vison) model of self injury: effects of CBP-CREB axis on nerve injury and behavior

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