The First Decade of Mandibular Distraction: Lessons We Have Learned

McCarthy, Joseph G.; Katzen, Janine; Hopper, Richard A.; Grayson, Barry H.

doi:10.1097/00006534-200212000-00013

Cited by 127 publications

(73 citation statements)

References 11 publications

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“…50 In addition, pin-tract infection is common 51 and cutaneous scars result from the pin use. 52 External devices can enable unidirectional, bidirectional, and multidirectional distraction, 53 whereas internal devices, in…”

Section: The Anchoring Tissuementioning

confidence: 99%

Biomechanical Configurations of Mandibular Transport Distraction Osteogenesis Devices

Zapata

Elsalanty

Dechow³

et al. 2010

Tissue Engineering Part B: Reviews

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Section: The Anchoring Tissuementioning

confidence: 99%

Biomechanical Configurations of Mandibular Transport Distraction Osteogenesis Devices

Zapata

Elsalanty

Dechow³

et al. 2010

Tissue Engineering Part B: Reviews

View full text Add to dashboard Cite

“…However, the long treatment period and the potential of fibrous union or nonunion under some circumstances remain major limitations that hamper its further clinical application. 1,2 Bone morphogenetic proteins (BMPs) are a group of osteoinductive proteins belonging to the TGFbeta superfamily, and are the most potent osteogenic factors discovered to date. The osteogenic function of BMPs is mediated by serine-threonine kinase cell surface transmembrane receptors and intracellular Smad signal cascades.…”

Section: Introductionmentioning

confidence: 99%

Callus formation enhanced by BMP‐7 ex vivo gene therapy during distraction osteogenesis in rats

Zou

et al. 2006

Journal Orthopaedic Research

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This study was designed to observe the effects of bone morphogenetic protein-7 (BMP-7) ex vivo gene therapy on callus formation during rat mandibular distraction osteogenesis (DO). Fifty-four Sprague-Dawley rats underwent osteodistraction of the right mandible and were then randomly divided into three groups. Immediately after distraction, autologous bone marrow mesenchymal stem cells (MSCs) transfected with BMP-7, MSCs untransfected with BMP-7, and physiological saline were injected into the distraction gaps of the mandibles in groups A, B, and C, respectively. Nine animals from each group were euthanized at 2 and 6 weeks after completion of distraction. The distracted mandibles were removed and processed for radiographic, histological, immunohistochemical, and scanning electron microscopic examinations as well as Ca/P ratio analysis. Group A animals showed greater bone formation and earlier mineralization in the distracted callus when compared with group B. Similarly increased callus formation was found in group B than group C. Positive immunostaining of BMP-7 was observed in the distracted callus in all groups. However, BMP-7 expression was much stronger in group A compared with groups B and C. The results of this study suggest that BMP-7-mediated ex vivo gene transfer based on MSCs may accelerate callus formation in distraction osteogenesis and facilitate consolidation. Local gene therapy may ultimately be an alternative or supplemental approach to DO enhancement, especially for patients whose osteogenic potentials are compromised by diseases such as osteoporosis, severe trauma, and postoncologic irradiation. ß

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“…16,17 Therefore, osteoinductive or angiogenic growth hormones or proteins were usually adopted to promote bone regeneration and shorten healing time. 6,7 In this study, the adiponectin was used to promote the new bone regeneration following DO. To maintain the effective local concentration, the distraction gap intermittent injection protocol was adopted.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5] However, the protracted treatment period and possible fibrous union or nonunion remain major limitation impeding its extensive clinical application. 6,7 Thus, facilitating the quality and rate of bone formation can markedly shorten the whole lengthening period and improve the postoperative quality of life, especially for the patients under poor osteogenic condition.…”

mentioning

confidence: 99%

Effect of intermittent administration of adiponectin on bone regeneration following mandibular osteodistraction in rabbits

Jiang

Song

et al. 2011

Journal Orthopaedic Research

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Adiponectin, a protein hormone produced and secreted exclusively by adipocytes, was reported to increase bone mass and stimulate angiogenesis. However, the effect of adiponectin on bone regeneration following distraction osteogenesis has not yet been reported. In this study, rapid unilateral mandibular osteodistraction (distraction rate ¼ 2 mm/day) was applied in 24 New Zealand white rabbits. The animals were then randomly divided into groups A and B (n ¼ 12 for each group). At the 1st, 3rd, and 5th day of the distraction, 200 ml PBS and 200 ml PBS contained 2 mg rh-adiponectin was intermittently injected into the distraction gap in groups A and B, respectively. At 6 weeks after the end of distraction, the rabbits were sacrificed, and the distracted mandibles were harvested and processed for radiography, dual energy X-ray absorptiometry (DXA), micro-CT, histology, and three-point bend testing. Under a rapid distraction, immature bone formation was seen in the distracted callus from group A. However, much greater bone formation and higher bone mineral density (BMD) and bone mineral content (BMC) of the distracted callus were observed in group B. Such finding was confirmed by histological, micro-CT examinations, and mechanical strength test. The results of this study suggest that intermittent administration of adiponectin can promote bone regeneration following rapid mandibular osteodistraction in rabbits. ß

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The First Decade of Mandibular Distraction: Lessons We Have Learned

Cited by 127 publications

References 11 publications

Biomechanical Configurations of Mandibular Transport Distraction Osteogenesis Devices

Biomechanical Configurations of Mandibular Transport Distraction Osteogenesis Devices

Callus formation enhanced by BMP‐7 ex vivo gene therapy during distraction osteogenesis in rats

Effect of intermittent administration of adiponectin on bone regeneration following mandibular osteodistraction in rabbits

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