The first comparison of photophysical and photochemical properties of non-ionic, ionic and zwitterionic gallium (III) and indium (III) phthalocyanines

Çamur, Meryem; Ahsen, Vefa; Durmuş, Mahmut

doi:10.1016/j.jphotochem.2011.02.014

Cited by 49 publications

(14 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 Most in vitro and vivo PDT studies have used aluminum, zinc and silicon Pc complexes or derivatives as photosensitizing agents 12 which has lead to several Pc complexes such as the silicon (IV) Pc complex and a liposomal preparation of zinc (II) Pc complex into the clinical trial stages. 13 Currently, sulfonated aluminum Pc complex (Photosens®) is being clinically used as a PDT agent in Russia for the treatment of a range of cancers 13 with no PDT-related pain reported during treatment. 5 Nonetheless, the photodynamic activity of many metal Pc complexes (e.g.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of gallium phthalocyanine as a photosensitizing agent in photodynamic therapy for the treatment of cancer

Maduray

Odhav

2012

SPIE Proceedings

View full text Add to dashboard Cite

Photodynamic therapy is a revolutionary treatment aimed at treating cancers without surgery or chemotherapy. It is based on the discovery that certain chemicals known as photosensitizing agents (e.g. porphyrins, phthalocyanines, etc.) can kill cancerous cells when exposed to low level laser light at a specific wavelength. The present study investigates the cellular uptake and photodynamic effect of gallium (III) phthalocyanine chloride (GaPcCl) on Caco-2 cancer cells. Caco-2 cells were treated with different concentrations of GaPcCl for 2 h before treatment with a diode laser (λ = 661 nm, laser power = 90 mW) delivering a light dose of 2.5 J/cm 2 , 4.5 J/cm 2 or 8.5 J/cm 2 . After 24 h, the cell viability of post-irradiated cells was measured using the MTT assay. Cellular uptake studies were performed by photosensitizing cells with GaPcCl for 30 min, 2 h, 10 h, 12 h, 18 h and 24 h before lysing the treated cells into solution to measure the GaPcCl fluorescence emission at an excitation wavelength of 600 nm. Results showed an increase in fluorescence intensity of emission peaks at longer incubation times, indicating a greater cellular uptake of GaPcCl by Caco-2 cells at 24 h in comparison to 30 min. GaPcCl at a concentration of 100 µg/ml activated with a laser light dose of 8.5 J/cm 2 reduced the cell viability of Caco-2 cells to 27%. This concludes that GaPcCl activated with low level laser light can be used as a photosensitizing agent for the in vitro PDT treatment of colon cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Efficacy of gallium phthalocyanine as a photosensitizing agent in photodynamic therapy for the treatment of cancer

Maduray

Odhav

2012

SPIE Proceedings

View full text Add to dashboard Cite

show abstract

“…The molecular ion of the unsubstituted PC often results as the major peak in the spectra; fragment ions of substituted phthalocyanine are due to the effect of thermal depolymerization, MALD-TOF electron ionization induce dissociation and thermal decomposition. [28,29,30] Even at 500°C, apparently under the ionization condition, metal (Zn/Cu) Scheme 1. Synthesis of metallo-ionic phthalocyanines.…”

Section: Synthesis Of Metallo-ionic Phthalocyaninesmentioning

confidence: 99%

Supramolecular Self‐Assembly Properties of Metallo‐Ionic Phthalocyanines Constituting Regioisomers

et al. 2020

View full text Add to dashboard Cite

We describe the synthesis and properties of metallo‐ionic phthalocyanines (MIPCs), obtained upon interacting metalled phthalocyaninetetracarboxylic acid with 1‐ethyl‐3‐methyl imidazolium chloride in a methanolic sodium hydroxide (NaOH) condition. Two MIPCs analyzed by 1H‐NMR and MALDI‐TOF, additionally, the four positional regioisomers (Cs, C4h, D2hand C2v) confirm by High Performance Liquid Chromatography (HPLC) analysis indicate the purity of the sample. The UV‐visible and photoluminescence spectroscopy used to characterize the effects of peripheral substituents on the absorption and emission spectroscopy that featured the distinctive J(Jelly) and H(hypsochromic) aggregates of MIPCs in a polar solvent. Electrochemical characteristics evaluated through cyclic voltammetry (CV) confirms the redox properties and the electron transfer mechanism studied by DFT calculations. Gelation experiment demonstrated on zinc‐ionic phthalocyanine shows the entangled network as evaluated using Scanning Electron Microscopy (SEM) images. We also studied the chromonic liquid crystalline behavior of MIPCs.

show abstract

“…In the literature, there are studies on the use of quinoline substituted phthalocyanine compounds in many different application areas. [37][38][39][40][41] The aim of this study is to demonstrate the effectiveness of new phthalocyanine compounds fused with quinoline against Alzheimer's (AD) and DM diseases with experimental approaches. Besides, we have presented computationally the biological activities of all compounds against different cancer proteins.…”

Section: Introductionmentioning

confidence: 99%

Quinoline‐fused both non‐peripheral and peripheral Zn^IIand Mg^IIphthalocyanines: Anti‐cholinesterase, anti‐α‐glucosidase, DNA nuclease, antioxidant activities, and in silico studies

Yalazan

Tüzün

Akkaya

et al. 2022

Applied Organom Chemis

View full text Add to dashboard Cite

Quinoline-fused Zn II (ZnPc p /ZnPc np ) and Mg II (MgPc p /MgPc np ) phthalocyanines with four 4-methylquinolin-2-ol (1) at non-peripheral or peripheral positions of the phthalocyanine core have been synthesized via cyclotetramerization of phthalonitrile derivatives (CN p /CN np ) in the presence of zinc (II) and magnesium (II) metal ions in this study. After synthesis and characterization processes, anti-cholinesterase, anti-α-glucosidase, DNA nuclease, antioxidant activities, and in silico calculations of both peripheral and non-peripheral Zn II and Mg II phthalocyanines were investigated. The inhibitory effects of metallated phthalocyanines on acetylcholinesterase, butyrylcholinesterase, and α-glucosidase enzymes were tested by spectrophotometric method. Theoretical methods are used to compare both the chemical and biological activities of the studied phthalonitrile derivatives and metallated phthalocyanine compounds.

show abstract

The first comparison of photophysical and photochemical properties of non-ionic, ionic and zwitterionic gallium (III) and indium (III) phthalocyanines

Cited by 49 publications

References 51 publications

Efficacy of gallium phthalocyanine as a photosensitizing agent in photodynamic therapy for the treatment of cancer

Efficacy of gallium phthalocyanine as a photosensitizing agent in photodynamic therapy for the treatment of cancer

Supramolecular Self‐Assembly Properties of Metallo‐Ionic Phthalocyanines Constituting Regioisomers

Quinoline‐fused both non‐peripheral and peripheral Zn^IIand Mg^IIphthalocyanines: Anti‐cholinesterase, anti‐α‐glucosidase, DNA nuclease, antioxidant activities, and in silico studies

Contact Info

Product

Resources

About

The first comparison of photophysical and photochemical properties of non-ionic, ionic and zwitterionic gallium (III) and indium (III) phthalocyanines

Cited by 49 publications

References 51 publications

Efficacy of gallium phthalocyanine as a photosensitizing agent in photodynamic therapy for the treatment of cancer

Efficacy of gallium phthalocyanine as a photosensitizing agent in photodynamic therapy for the treatment of cancer

Supramolecular Self‐Assembly Properties of Metallo‐Ionic Phthalocyanines Constituting Regioisomers

Quinoline‐fused both non‐peripheral and peripheral ZnIIand MgIIphthalocyanines: Anti‐cholinesterase, anti‐α‐glucosidase, DNA nuclease, antioxidant activities, and in silico studies

Contact Info

Product

Resources

About

Quinoline‐fused both non‐peripheral and peripheral Zn^IIand Mg^IIphthalocyanines: Anti‐cholinesterase, anti‐α‐glucosidase, DNA nuclease, antioxidant activities, and in silico studies