The first choice of the preimplantation embryo: How compaction and polarity build cell identity

Martin, Angel; Santos, Ma José de los

doi:10.1016/j.medre.2020.01.001

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2023

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“…Embryo compaction, which is the first critical morphogenetic process that occurs during embryonic development is initiated at the 8-cell stage ( 25 ). Starting from cell contact points proceeding outwards, adjacent blastomeres flatten against each other, maximizing their contacts and generating a mass of cells with no distinguishable cell boundaries ( 26 ).…”

Section: Adherens Junctionsmentioning

confidence: 99%

Overview of junctional complexes during mammalian early embryonic development

2023

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Cell-cell junctions form strong intercellular connections and mediate communication between blastomeres during preimplantation embryonic development and thus are crucial for cell integrity, polarity, cell fate specification and morphogenesis. Together with cell adhesion molecules and cytoskeletal elements, intercellular junctions orchestrate mechanotransduction, morphokinetics and signaling networks during the development of early embryos. This review focuses on the structure, organization, function and expressional pattern of the cell–cell junction complexes during early embryonic development. Understanding the importance of dynamic junction formation and maturation processes will shed light on the molecular mechanism behind developmental abnormalities of early embryos during the preimplantation period.

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Section: Adherens Junctionsmentioning

confidence: 99%