The first case series of Chinese patients in Hong Kong with familial Alzheimer’s disease compared with those with biomarker-confirmed sporadic late-onset Alzheimer’s disease

Shea, Yat‐Fung; Chu, Leung Wing; Sc, Lee; Chan, Alex W.H.

doi:10.12809/hkmj176845

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…Familial AD has been reported in Hong Kong, and these patients may need to be referred for genetic counselling and testing. 48,49 This should be followed by a complete physical examination, including a neurological examination, to identify any clinical features of obstructive sleep apnoea, focal neurologic signs that may suggest vascular aetiology, or bradykinesia, rigidity, or tremors that would suggest a Parkinsonian syndrome. 12…”

Section: History and Physical Examinationmentioning

confidence: 99%

Assessment and diagnosis of dementia: a review for primary healthcare professionals

Lam

Chan

Luk³

et al. 2019

Hong Kong Med J

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Dementia is one of the most costly, disabling diseases associated with ageing, yet it remains underdiagnosed in primary care. In this article, we present the comprehensive approach illustrated with a classical case for diagnosing dementia which can be applied by healthcare professionals in primary care. This diagnostic approach includes history taking and physical examination, cognitive testing, informant interviews, neuropsychological testing, neuroimaging, and the utility of cerebrospinal fluid biomarkers. For the differential diagnosis of cognitive impairment, the differences and similarities among normal ageing, mild cognitive impairment, depression, and delirium are highlighted. As primary care physicians are playing an increasingly prominent role in the caring of elderly patients in an ageing population, their role in the diagnosis of

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Section: History and Physical Examinationmentioning

confidence: 99%

Assessment and diagnosis of dementia: a review for primary healthcare professionals

Lam

Chan

Luk³

et al. 2019

Hong Kong Med J

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“…Many theories about pathological processes can be learned from literature including genetics which can play a role in some types of familiar and early-onset degenerative disorders of Alzheimer type (9)(10)(11) and be a link between immunity and the disease (12,13). When searching the molecular processes related to Alzheimer disease, two dominant pathological hallmarks were identifi ed.…”

Section: Current Therapy and The Major Pathological Processes Relatedmentioning

confidence: 99%

Oxidative stress in Alzheimer disease as a target for therapy

Pohanka¹

2018

BLL

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In the recent time, neurodegenerative disorders like Alzheimer disease were recognized for their significant role in the current healthcare because of their growing incidence and costs for health insurance systems. Effective therapy is missing and even etiology of the diseases like Alzheimer disease is not deeply known. In the case of Alzheimer disease, it is probable that oxidative stress is at least a factor involved in the disease. Nevertheless, the current literature is controversial and ambiguous in this matter. This review is focused on mapping the role of oxidative stress as well as on a consideration that oxidative stress represents the pathway at which a therapeutic strategy can be aimed. This paper provides a survey of contemporary literature on oxidative stress in Alzheimer disease and discusses the opportunities for establishing a therapy based on interfering the stress (Fig. 5, Ref. 117).

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“…Recent studies in Hong Kong have also highlighted some novel findings that could be applicable for care of dementia. [24][25][26][27][28] In addition to training professionals, building an appropriately structured partnership, EDITORIAL which takes incentives for both primary care providers and specialists, the welfare of patients and caregivers, and the cost of government and society into consideration, is also a challenge for policymakers in redesigning healthcare policy. It is also essential to enhance public awareness so that dementia patients and their caregivers are encouraged to seek help from professional care facilities for reducing their physical and mental burden.…”

mentioning

confidence: 99%

Crucial role of primary healthcare professionals in the assessment and diagnosis of dementia

2019

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The first case series of Chinese patients in Hong Kong with familial Alzheimer’s disease compared with those with biomarker-confirmed sporadic late-onset Alzheimer’s disease

Cited by 4 publications

References 19 publications

Assessment and diagnosis of dementia: a review for primary healthcare professionals

Assessment and diagnosis of dementia: a review for primary healthcare professionals

Oxidative stress in Alzheimer disease as a target for therapy

Crucial role of primary healthcare professionals in the assessment and diagnosis of dementia

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