The first case report of Leishmania (leishmania) chagasi in Panthera leo in Brazil

Dahroug, Magyda Arabia Araji; Almeida, Arleana B.P.F.; Sousa, Valéria Régia Franco; Dutra, Valéria; Guimarães, Lia Buarque de Macedo; Soares, César E; Souza, Roberto Lopes de

doi:10.1016/s2221-1691(11)60036-1

Cited by 19 publications

(9 citation statements)

References 13 publications

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“…About 70 species of mammals, including humans, are considered vertebrate hosts of different species of Leishmania around the world, and some of them are reservoirs of the parasite in nature [ 1 ]. Although the natural infection in rodents [ 3 , 4 ] and canids [ 5 – 10 ] is more common, the parasite is able to infect xenarthrans [ 11 , 12 ], hyraxes [ 13 ], marsupials [ 14 ], chiropterans [ 15 – 17 ], lagomorphs [ 18 – 21 ], procyonids [ 11 , 22 ], felids [ 23 – 26 ], Perissodactyla [ 27 , 28 ], and primates [ 11 , 29 ]. Determining the precise role played by each host in the transmission cycle remains a challenge.…”

Section: Introductionmentioning

confidence: 99%

Canine Leishmaniasis: An Overview of the Current Status and Strategies for Control

Ribeiro

Michalick

Silva

et al. 2018

BioMed Research International

123

109

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Canine leishmaniasis (CanL) is a vector-borne disease caused by Leishmania infantum and is transmitted by female phlebotomine sand flies primarily between animals and secondarily to humans. The course of infection may be different from one individual dog to another, ranging from spontaneous cure to acute evolution that leads to death, if proper management and therapy are not adopted. A parasitological cure is rarely achieved and clinical recurrences in CanL are frequent. Vaccination associated with the use of topical insecticides is undoubtedly the most effective form of prevention and control of the disease. In order to integrate the most important scientific knowledge of the literature in one objective publication, this review proposes a short overview of the main points of CanL.

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Section: Introductionmentioning

confidence: 99%

Canine Leishmaniasis: An Overview of the Current Status and Strategies for Control

Ribeiro

Michalick

Silva

et al. 2018

BioMed Research International

123

109

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“…Infection with or without clinical disease has also been reported in non-domestic canines, such as foxes, wolves and jackals (Beck et al, 2008;Fallah and Khanmohammadi, 2011;, and in lions (Dahroug et al, 2011;Libert et al, 2012). Leishmania has also been detected in other wild carnivores, such as Egyptian mongooses and genets and Iberian lynx (Sobrino et al, 2008).…”

Section: Affected Speciesmentioning

confidence: 99%

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2015

EFSA Journal

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“…However, in endemic areas, there is a higher prevalence of subclinical infection than clinical disease in dogs (Moreno and Alvar, 2002, Miro et al, 2008, Solano-Gallego et al, 2009 (Fallah and Khanmohammadi, 2011, Tenorio Mda et al, 2011, Beck et al, 2008, Luppi et al, 2008 and lions (Dahroug et al, 2011, Libert et al, 2012.…”

Section: Animal Species Affected By Clinical Diseasementioning

confidence: 99%

“…The major route of transmission of the parasite in both canine and human populations was considered to be via bites of phlebotomine sand flies. Although many infections remain subclinical, leishmaniosis has been reported to cause disease in companion animals, wildlife species and humans (Poli et al, 2002, Marcos et al, 2009, Navarro et al, 2010, Ozon et al, 1998, Hervas et al, 1999, Solano-Gallego et al, 2003, Rolao et al, 2005, Koehler et al, 2002, Fallah and Khanmohammadi, 2011, Tenorio Mda et al, 2011, Beck et al, 2008, Luppi et al, 2008, Dahroug et al, 2011, Libert et al, 2012, Ready, 2010, SolanoGallego et al, 2011. Routinely collected companion animal epidemiological data were not available and based on results of an online veterinary questionnaire, clinical cases of CanL were estimated to be common in endemic parts of the EU with greatest estimates in Italy and Greece, and least disease reported in France of the five studied countries.…”

Section: Supporting Publications 2013:en-466 159mentioning

confidence: 99%

Data collection to characterise the impact of canine leishmaniosis and modelling of the role of animals in spreading Leishmania infantum within the European Union

Mattin

Brodbelt

Wylie

et al. 2014

EFSA Supporting Publications

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Canine leishmaniosis (CanL) is a major zoonosis transmitted by sand flies which can potentially cause severe fatal disease in humans and dogs. The disease is endemic in southern Europe and there are concerns about its introduction into the non-endemic areas of the European Union (EU). The objectives of this work were to investigate the efficacy of different control measures using a systematic review (SR), assess the role of dogs in the spread of Leishmania Infantum (L. infantum) in the EU and evaluate potential mitigation measures using simulation modelling, and evaluate the impact of the disease in endemic areas. The SR evaluated the effectiveness and safety of control measures for CanL using 23 clinical trials conducted on a total of 5861 dogs. Significant benefits were observed in the intervention groups for a number of vaccine types, deltamethrin collars, spot-ons, and prophylactic medication with domperidone. However, these results require confirmation in adequately powered well designed randomised controlled trials. The results of the stochastic simulation modelling suggest that there is a high risk of endemicity for disease-free EU regions with presence of a competent vector and where infected dogs are introduced. When evaluated individually and at a high level of implementation, the best mitigation measures in decreasing order of effectiveness were: repellent, vaccine, prophylactic medication and insecticide. Some combinations of mitigation measures showed a joint effect higher than the effect of individual measures. Test and exclusion of positive dogs moving into non-endemic areas was effective for low numbers of imports, but its benefits diminished as the number of imported dogs increased, given the low sensitivity of the diagnostic test used. The results of the impact assessment suggest clinical CanL is a common diagnosis in endemic parts of the EU. The estimated percentage of practice-attending dogs with a veterinary diagnosis of CanL by country was as follows: France 0.71%, Spain 3.71%, Portugal 2.92%, Italy 4.25% and Greece 7.80%. CanL can have a significant impact on the welfare of affected dogs and economic implications for owners, both for prevention and treatment. It is estimated that the use of preventative collars in these five countries cost dog owners €54 million in 2012 alone. The incidence of clinical human leishmaniosis is much lower than CanL, with reported data suggesting between 20 and 380 hospital admissions per country per year. Costs relating to hospital fees and time off work may amount to approximately €4.5million/year in Spain, Portugal, Italy and Greece. The current economic crisis is likely to have an adverse impact on the prevention and control of CanL.

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The first case report of Leishmania (leishmania) chagasi in Panthera leo in Brazil

Cited by 19 publications

References 13 publications

Canine Leishmaniasis: An Overview of the Current Status and Strategies for Control

Canine Leishmaniasis: An Overview of the Current Status and Strategies for Control

Untitled

Data collection to characterise the impact of canine leishmaniosis and modelling of the role of animals in spreading Leishmania infantum within the European Union

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