The first asymmetric synthesis of all four isomers of cis- and trans-3,4-dihydroxy-3,4-dihydromollugin

Mudiganti, Naga Venkata Sastry; Claessens, Sven; Kimpe, Norbert De

doi:10.1016/j.tetlet.2008.09.138

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Hence, 2 was identified as the new 1-hydroxy-4-methoxy-3′,3′-dimethyl-3 H -benzo[ f ]chromene-2-carboxylic acid and was given the trivial name busseihydroquinone B. It should be noted that 2 is isomeric to mollugin, a natural product isolated from Pentas longiflora and synthetically extensively explored by De Kimpe et al − …”

Section: Resultsmentioning

confidence: 99%

Busseihydroquinones A–D from the Roots of Pentas bussei

et al. 2012

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Four new naphthohydroquinones, named busseihydroquinones A−D (1−4), along with a known homoprenylated dihydronaphthoquinone (5), were isolated from the CH 2 Cl 2 /MeOH (1:1) extract of the roots of Pentas bussei. Although the genus Pentas is frequently used by traditional healers for the treatment of malaria, only marginal activities against the chloroquine-sensitive (D6) and the chloroquineresistant (W2) strains of Plasmodium falciparum were observed for the crude root extract and the isolated constituents of this plant.

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Section: Resultsmentioning

confidence: 99%

Busseihydroquinones A–D from the Roots of Pentas bussei

et al. 2012

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“…Interestingly, the yellow bulk crystals were obtained from dye solution, which were confirmed to be mollugin by single crystal X-ray diffraction. On one hand, the mollugin was used as medicine with antitumor, antiviral and other activities, however, its crystal structure and fluorescence property were not well studied [19, 20, 21, 22]. Here, the cotton (natural fiber) and nylon (synthetic fiber) samples were chose to dye with the extracted solution before and after crystallization [23].…”

Section: Introductionmentioning

confidence: 99%

Simple crystallization approach for enhancing function of plant-based madder dye and performance of dyed fabric

Wang

Tian

et al. 2019

Heliyon

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In the present study, the natural madder dye was investigated to the simultaneous extraction and dyeing of cotton (natural fiber) and nylon (synthetic fiber). The optimum dye extraction conditions were found to be 80 °C, 60 min, and 1:6 with ethyl alcohol after madder had been fermenting for 24 hours with water as solvent. Interestingly, crystallization can be done to separate crystal mollugin from dyed solution. And then, dyed fabrics exhibited improved color strength and ultraviolet protection factor. Meanwhile, the mollugin showed a strong fluorescence emission with maximum emission band at 464 nm with 372 nm excitation in the solid state, which may provide potential molecular system for bio-based optoelectronics and chemical sensors.

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Facile Synthesis of Mollugin by Kinetic Control and anti-HCV (Hepatitis C Virus) Activity of Its Analogues

Kim¹,

Kim²,

Lee³

et al. 2014

Bulletin of the Korean Chemical Society

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Mollugin has been reported to have various biological activities including antineoplastic, antitumor, antiviral against the hepatitis B virus, anti-aging and antimutagenic activities. An effective and concise synthesis of mollugin in two steps including kinetic control from the cheap starting material 1,4-naphthoquinone has been introduced, and mollugin derivatives thus prepared are screened for their inhibition ability against the hepatitis C virus (HCV) and the dihydrobenzochromene structure might be an additional anti-HCV agent as a new leading compound.

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The first asymmetric synthesis of all four isomers of cis- and trans-3,4-dihydroxy-3,4-dihydromollugin

Cited by 3 publications

References 18 publications

Busseihydroquinones A–D from the Roots of Pentas bussei

Busseihydroquinones A–D from the Roots of Pentas bussei

Simple crystallization approach for enhancing function of plant-based madder dye and performance of dyed fabric

Facile Synthesis of Mollugin by Kinetic Control and anti-HCV (Hepatitis C Virus) Activity of Its Analogues

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