The first 2019 novel coronavirus case in Nepal

Bastola, Anup; Sah, Ranjit; Rodríguez‐Morales, Alfonso J.; Lal, Bibek Kumar; Jha, Runa; Ojha, Hemant Chanda; Shrestha, B; Chu, Daniel K W; Poon, Leo L M; Costello, Anthony; Morita, Kouichi; Pandey, Basu Dev

doi:10.1016/s1473-3099(20)30067-0

Cited by 288 publications

(302 citation statements)

References 6 publications

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“…In addition, the mortality rate of the first and second phases of the epidemic was 4.3-15% and thus significantly higher than the 1.36% determined for the later phase of the epidemic [13,21,29,33,34]. This higher mortality rate was either due to: (i) more people with underlying medical conditions, such as high blood pressure and diabetes [12,13,19,20,29,31,33];…”

Section: Clinical Phenotype Of Covid-19mentioning

confidence: 80%

“…Some patients showed atypical symptoms, such as diarrhea and vomiting. However, the clinical phenotype is confounded by the fact that 25.2% patients had at least one other underlying medical condition [13,15,[29][30][31][32]. The overall clinical characteristics of COVID-19 were also influenced by the different phases of this epidemic [12,13,21,29,33].…”

Section: Clinical Phenotype Of Covid-19mentioning

confidence: 99%

“…Asymptomatic infection was also documented in Germany: two asymptomatic patients' throat samples were tested positive by reverse transcription (RT)-PCR and by virus isolation, while both patients remained well and afebrile for 7 days [38]. Importantly, the asymptomatic manifestation jeopardizes the screening of infected people by temperature measurements or by overt signs and symptoms [12,13,19,20,29,31,33]. Virus infection is not selective in age, as it was reported even in a 1-month-old infant [20,21,37].…”

Section: Clinical Phenotype Of Covid-19mentioning

confidence: 99%

See 2 more Smart Citations

COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives

Sun

Wang

et al. 2020

Trends in Molecular Medicine

577

526

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Section: Clinical Phenotype Of Covid-19mentioning

confidence: 80%

Section: Clinical Phenotype Of Covid-19mentioning

confidence: 99%

Section: Clinical Phenotype Of Covid-19mentioning

confidence: 99%

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COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives

Sun

Wang

et al. 2020

Trends in Molecular Medicine

577

526

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“…The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), formerly known as the 2019 novel Coronavirus (2019nCoV), is a newly emerging zoonotic agent that appeared in December 2019 and causes the Coronavirus Disease 2019 (COVID-19) [1]. This pathogen results in a syndrome leading in some cases to a critical care respiratory condition, that requires specialized management at intensive care units (ICU) in many of them [2][3][4][5][6][7]. The SARS-CoV-2, taxonomically, is currently part of the species of the SARS-related coronaviruses that belong to the subgenus Sarbecovirus.…”

Section: Rationalementioning

confidence: 99%

Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis

Rodríguez‐Morales

Cardona-Ospina

Gutiérrez‐Ocampo

et al. 2020

Travel Medicine and Infectious Disease

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Methods:We performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. Observational studies and also case reports, were included, and analyzed separately. We performed a random-effects model meta-analysis to calculate the pooled prevalence and 95% confidence interval (95%CI).Results: 660 articles were retrieved for the time frame (1/1/2020-2/23/2020). After screening, 27 articles were selected for full-text assessment, 19 being finally included for qualitative and quantitative analyses. Additionally, 39 case report articles were included and analyzed separately. For 656 patients, fever (88.7%, 95%CI 84.5-92.9%), cough (57.6%, 40.8-74.4%) and dyspnea (45.6%, 10.9-80.4%) were the most prevalent manifestations. Among the patients, 20.3% (95%CI 10.0-30.6%) required intensive care unit (ICU), 32.8% presented with acute respiratory distress syndrome (ARDS) (95%CI 13.7-51.8), 6.2% (95%CI 3.1-9.3) with shock. Some 13.9% (95%CI 6.2-21.5%) of hospitalized patients had fatal outcomes (case fatality rate, CFR).Conclusion: COVID-19 brings a huge burden to healthcare facilities, especially in patients with comorbidities. ICU was required for approximately 20% of polymorbid, COVID-19 infected patients and hospitalization was associated with a CFR of over 13%. As this virus spreads globally, countries need to urgently prepare human resources, infrastructure and facilities to treat severe COVID-19.

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“…The virus has been detected in bronchoalveolar-lavage (Zhu et al, 2019), sputum (Lin et al, 2020), saliva (K.K. , throat (Bastola et al, 2020) and nasopharyngeal swabs .…”

Section: The Studymentioning

confidence: 99%

Genetic diversity and evolution of SARS-CoV-2

Phan

2020

Infection, Genetics and Evolution

600

585

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A B S T R A C TCOVID-19 is a viral respiratory illness caused by a new coronavirus called SARS-CoV-2. The World Health Organization declared the SARS-CoV-2 outbreak a global public health emergency. We performed genetic analyses of eighty-six complete or near-complete genomes of SARS-CoV-2 and revealed many mutations and deletions on coding and non-coding regions. These observations provided evidence of the genetic diversity and rapid evolution of this novel coronavirus.

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The first 2019 novel coronavirus case in Nepal

Cited by 288 publications

References 6 publications

COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives

COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives

Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis

Genetic diversity and evolution of SARS-CoV-2

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