The first 1000 days: A critical period of nutritional opportunity and vulnerability

Scott, Jane

doi:10.1111/1747-0080.12617

Cited by 23 publications

(20 citation statements)

References 23 publications

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“…Pregnancy and the first 1000 days of life are a critical period during which nutrition can have lifelong impacts on mother and child [ 1 , 8 , 9 ]. However, pregnancy is also a life stage that presents particular challenges to preparing and consuming healthy meals and snacks [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…These conditions are associated with increased risk of maternal, perinatal, and neonatal complications including early pregnancy loss, abnormal fetal growth patterns, labor complications, preterm birth, postpartum weight retention, childhood obesity, and cardiovascular disease and impaired glucose metabolism in mother and child [ 4 , 6 ]. Additionally, the first 1000 days of life—from conception to age two—have been identified as a critical period for physical and cognitive development during which optimal nutrition is key [ 1 , 8 , 9 ]. Thus, interventions to improve diet quality during pregnancy provide a unique and powerful opportunity to improve health across the lifespan.…”

Section: Introductionmentioning

confidence: 99%

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A Qualitative Study of Motivators, Strategies, Barriers, and Learning Needs Related to Healthy Cooking during Pregnancy

et al. 2021

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Nutrition during pregnancy has lifelong impacts on the health of mother and child. However, this life stage presents unique challenges to healthy cooking and eating. Cooking interventions show promising results, but often lack theoretical basis and rigorous evaluation. The objective of this formative, qualitative study was to explore motivators, strategies, and barriers related to healthy cooking during pregnancy. Pregnant individuals’ preferences for a cooking education program were also explored. We conducted five focus groups with pregnant individuals (n = 20) in Southeast Michigan in 2019. Focus groups were audio-recorded and transcribed verbatim, then double coded by two members of the research team. Mean gestational age was 18.3 ± 9.6 weeks. Common motivators included feeding other children, avoiding pregnancy complications, promoting fetal growth, and avoiding foodborne illness. Challenges included pregnancy symptoms, navigating nutrition recommendations, mental energy of meal planning, family preferences, and time constraints. Strategies employed were meal planning and including a variety of foods. Participants identified organizational strategies, recipes, nutrition information, and peer support as important components of a cooking intervention during pregnancy. This study characterized multiple challenges to healthy home cooking during pregnancy, providing novel insight to inform the development of cooking skills education programs during this important life stage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Qualitative Study of Motivators, Strategies, Barriers, and Learning Needs Related to Healthy Cooking during Pregnancy

et al. 2021

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“…This systematic review was designed to assess the evidence for an association between prenatal exposure to mercury and neurodevelopment in early childhood (0–5 years) from studies published up to December 2020. The age range of 0–5 years was selected because the first years of infancy are understood to form a critical window of brain development [ 29 ], and the clearance rate of mercury and methylmercury is such that prenatal exposure would not be expected to last beyond the first few years of life [ 30 , 31 ]. Studies which used biological samples to measure mercury concentrations during pregnancy or at delivery were included; ethylmercury was not included because the pathways to exposure and biological mechanisms are different from other forms of mercury.…”

Section: Methodsmentioning

confidence: 99%

Prenatal Mercury Exposure and Neurodevelopment up to the Age of 5 Years: A Systematic Review

Dack

Fell

Taylor

et al. 2022

IJERPH

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Neurodevelopmental delays can interfere with children’s engagement with the world and further development, and may have negative consequences into adulthood. Mercury is highly toxic and may negatively influence neurodevelopment because it can freely cross the placenta and accumulate in the fetal brain. We searched four publication databases (Embase, PsycINFO, PubMed/MEDLINE, Scopus) for studies examining the relationship between early life mercury exposure and scores on neurodevelopmental performance measures in children aged 0 to 5 years old. Study quality was assessed using the National Institutes of Health (NIH) Quality Assessment Tool. Thirty-two prospective studies were included in the review. Neurodevelopmental performance was measured using 23 different scales, most commonly the Bayley Scales of Infant and Toddler Development (BSID). In most cases, the evidence for an association between mercury and neurodevelopment was weak. There did not appear to be exceptions for particular childhood ages, outcome scales, or mercury levels. The small number of results to the contrary were more likely to be studies which did not meet our high-quality criteria, and could be a consequence of multiple testing, selection bias, or incomplete confounder adjustment. Based on current evidence, dietary mercury exposure during pregnancy is unlikely to be a risk factor for low neurodevelopmental functioning in early childhood.

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“…Disruption or delay to the formation of the PNN results in the resumption or extension of the time window for neuroplasticity in the brain [23], wherein the nervous system is more sensitive to epigenetic, physical, biochemical, environmental, and nutritional factors. The effects of nutrition on individuals during gestational and early development have been extensively researched, leading many researchers to conclude that nutritional factors such as vitamins, folate and iodine can cause long-lasting impacts in neurodevelopment [24,25]. As the foetus' and newborn's acquisition of vitamins like B 12 and D, depends to a great extent on maternal diet, such research has increasingly focussed on the impact of the mothers' vitamin deficiency on their offspring's brain development during the foetal and exclusive breastfeeding stages.…”

Section: Effect Of Reelin Concentrations In the Ecm On Nmda Signalling Reelin Activates Adaptor Protein Disabled 1 (Dab1) By Binding Withmentioning

confidence: 99%

Vitamins D and B₁₂, Altered Synaptic Plasticity and Extracellular Matrix

Echeverry¹,

Takada²,

Arruda³

et al. 2022

B-Complex Vitamins - Sources, Intakes and Novel Applications

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Brain plasticity is regulated through dynamic interactions between perineuronal nets, matrix metalloproteases (MMPs) and the extracellular matrix (ECM). Several studies have identified a crucial role for vitamins D and B12 in brain development and a deficiency in these vitamins may contribute to the emergence of cognitive deficits, as well as the onset of both autism spectrum disorder and schizophrenia. However, the mechanisms underlying the interplay between ECM, MMPs, vitamins and these neuropsychiatric conditions are poorly understood. In this chapter, we seek to understand how the risk of neurodegeneration in vulnerable individuals and the aetiology of specific neuropsychiatric disorders are affected by vitamin D and B12 deficiency, in conjunction with low levels of the antioxidant glutathione, impaired GABAergic inhibition, and alterations in the permanent ECM.

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The first 1000 days: A critical period of nutritional opportunity and vulnerability

Cited by 23 publications

References 23 publications

A Qualitative Study of Motivators, Strategies, Barriers, and Learning Needs Related to Healthy Cooking during Pregnancy

A Qualitative Study of Motivators, Strategies, Barriers, and Learning Needs Related to Healthy Cooking during Pregnancy

Prenatal Mercury Exposure and Neurodevelopment up to the Age of 5 Years: A Systematic Review

Vitamins D and B₁₂, Altered Synaptic Plasticity and Extracellular Matrix

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The first 1000 days: A critical period of nutritional opportunity and vulnerability

Cited by 23 publications

References 23 publications

A Qualitative Study of Motivators, Strategies, Barriers, and Learning Needs Related to Healthy Cooking during Pregnancy

A Qualitative Study of Motivators, Strategies, Barriers, and Learning Needs Related to Healthy Cooking during Pregnancy

Prenatal Mercury Exposure and Neurodevelopment up to the Age of 5 Years: A Systematic Review

Vitamins D and B12, Altered Synaptic Plasticity and Extracellular Matrix

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Vitamins D and B₁₂, Altered Synaptic Plasticity and Extracellular Matrix