The firing activity of pyramidal neurons in medial prefrontal cortex and their response to 5-hydroxytryptamine-1A receptor stimulation in a rat model of Parkinson's disease

Acute and chronic methylphenidate alters prefrontal cortex neuronal activity recorded from freely behaving rats

“…All the recordings were confirmed to be recorded from the PFC after the histological verification. Most of the PFC neurons exhibited low firing rates between 0.1 to 5 spikes per second, similar observation was reported by Wang et al, (2009).…”

Activation of 5-HT1A receptors in the medial subdivision of the central nucleus of the amygdala produces anxiolytic effects in a rat model of Parkinson's disease

“…The neuronal loss in the midbrain raphe nuclei leads to reductions in 5-HT and 5-HT transporter levels in several brain areas, as well as alterations in the expression and function of subtypes of 5-HT receptors (Huot et al, 2011), especially in the changes of 5-HT 1A receptor levels (Chen et al, 1998;Frechilla et al, 2001;Hou et al, 2012). Electrophysiological studies from our laboratory have found that the lesion of the SNc results in the decreased response of neurons in the medial prefrontal cortex (mPFC) and DRN to 5-HT 1A receptors stimulation (Hou et al, 2012;Wang et al, 2009). Therefore, it is suggested that dysfunction and/or down-regulation of 5-HT 1A receptors appear to be a critical factor for anxiety in PD.…”

A combined solenoid‐surface RF coil for high‐resolution whole‐brain rat imaging on a 3.0 tesla clinical MR scanner

“…Coil performance was evaluated with the CuSO 4 phantom doped with NaCl. The following coils were assessed: (1) the rat brain coil, (2) a two‐channel phased‐array surface coil (24) (Pathway MRI, Seattle, WA), (3) a mouse body coil (Philips), (4) a 3‐cm surface coil, and (5) a modified Helmholtz coil. The two‐channel phased‐array surface coil and mouse body coil are commercially available products, and technical details can be obtained either from Hayes et al (24) or the manufacturer, respectively.…”

“…Models derived from the rat brain have been used to study human neurological disorders from a spectrum of disciplines, including oncology (1), trauma (2), psychiatry (3), and neurology (4). MRI has extended research opportunities within these fields by affording the serial evaluation of the in vivo rat brain to monitor disease progression and/or response to therapy.…”

“…In this study, we sought to develop an RF receive‐only coil dedicated for rat whole‐brain imaging at 3.0 T. The advantages provided by solenoid and surface coils were combined to yield a multichannel coil with high SNR specific to the entire rat brain volume. Performance was compared with (1) a commercially available, two‐channel, phased‐array carotid surface coil; (2) a commercially available multiturn solenoid mouse body coil; (3) a single‐loop, surface coil with internal diameter of 3 cm; and (4) a two‐turn, single‐channel solenoid coil (i.e., a modified Helmholtz coil).…”