The Finnish evidence‐based guideline for open‐angle glaucoma

Tuulonen, Anja; Pj, Airaksinen; Erola, E; Forsman, Eva; Friberg, Kalevi; Kaila, Minna; Klemetti, Anneli; Mākelä, Marjukka; Oskala, Pertti; Puska, Päivi; Suoranta, Liisa; Teir, H; Uusitalo, H; Vainio-Jylhä, Elina; Ml, Vuori

doi:10.1034/j.1600-0420.2003.00021.x

Cited by 84 publications

(125 citation statements)

References 199 publications

(222 reference statements)

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…XFS is a major risk factor for development and progression of exfoliation glaucoma (XFG). 1 Approximately one quarter of XFS patients have elevated intraocular pressure and one-third of these have XFG. [2][3][4] XFS and XFG occur worldwide, but their prevalence varies between different populations.…”

Section: Introductionmentioning

confidence: 99%

Association of LOXL1 gene with Finnish exfoliation syndrome patients

et al. 2009

View full text Add to dashboard Cite

In this study, three single-nucleotide polymorphisms (SNPs) on the lysyl oxidase-like 1 (LOXL1) gene associated with exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) were investigated in the Finnish population. A case-control study of 59 sporadic patients with XFS, 82 with XFG, 71 with primary open-angle glaucoma (POAG) and 26 individuals without these disorders from the southern Finnish population, and a family study of an extended family with 28 patients with XFS or XFG and 92 unaffected relatives from Kö kar islands, Southwestern Finnish archipelago, were conducted. Anonymous blood donors (n¼404) were studied as population-based controls. Three SNPs, rs1048661 (R141L), rs3825942 (G153D) and rs2165241, of the LOXL1 gene were genotyped by PCR sequencing. Association and linkage analyses were carried out. In both case-control and family materials, significant association for allele G of rs1048661 (P¼2.65Â10 À5 ; P¼0.0007), allele G of rs3825942 (P¼2.24Â10 À8 ; P¼0.49) and allele T of rs2165241 (P¼2.62Â10 À13 ; Po0.0001) was found in XFS/XFG. However, linkage was not observed for LOXL1 risk alleles. The corresponding three-locus haplotype GGT increased the risk of XFS/ XFG nearly 15-fold relative to low-risk haplotype GAC (odds ratio (OR): 14.9, P¼1.6Â10 À16 ). In conclusion, the earlier reported polymorphisms of the LOXL1 gene showed significant association also in the Finnish population.

show abstract

Section: Introductionmentioning

confidence: 99%

Association of LOXL1 gene with Finnish exfoliation syndrome patients

et al. 2009

View full text Add to dashboard Cite

show abstract

“…3,5,7,304 Evidence-based guidelines for the management of OAG are in development as part of the clinical guidelines programme of NICE. 305 Criterion met?…”

Section: Does Screening For Open Angle Glaucoma Meet the National Scrmentioning

confidence: 99%

“…Screening for OAG among 'at-risk' target populations with interval screening offered at selected sites has not been adopted in any country, but a number of ad hoc strategies exists, with clinical guidelines for the detection and subsequent management of glaucoma. [3][4][5][6][7] For screening for OAG to be considered, several criteria should be addressed. In the UK, the NSC provides advice to government on which population screening programmes should be introduced.…”

Section: Introductionmentioning

confidence: 99%

The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation

Burr¹,

Mowatt²,

Hernández³

et al. 2007

Health Technol Assess

328

380

View full text Add to dashboard Cite

Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment ProgrammeT he Health Technology Assessment (HTA) programme, now part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the costs, effectiveness and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care, rather than settings of care. The research findings from the HTA Programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA Programme is needs-led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research are actively sought from people working in the NHS, the public and consumer groups and professional bodies such as r...

show abstract

“…This fact may support the use of RNFL red-free photography because evaluation of the entire bundle of fibers could be more accurate than evaluation with imaging devices of the peripapillary retina. In fact, there are no reports on this type of glaucoma in the literature (6), and the Finnish Guideline for Open-Angle Glaucoma recommends that a diagnosis other than glaucoma be considered (eg, neurologic disease) in such cases.…”

Section: Eyementioning

confidence: 99%

“…3 Major scientific societies have presented recommendations for glaucoma management, for example, the European Glaucoma Society Guidelines, the American Academy of Ophthalmology Preferred Practice Patterns for Open-Angle Glaucoma, and the Finnish Evidence-Based Guideline for Open-Angle Glaucoma. [4][5][6] The latter guideline is on the basis of evaluation of the ONH and RNFL and the recommendations for action are on the basis of very high quality studies. These guidelines are aimed at providing a uniform diagnosis and treatment of glaucoma by applying evidence-based knowledge to central issues.…”

Section: Introductionmentioning

confidence: 99%

Performance of GDx and HRT in the Finnish Evidence-Based Guideline for Open-Angle Glaucoma

Pablo

Larrosa

Polo

et al. 2009

Eye

View full text Add to dashboard Cite

Aim To compare the performance of Heidelberg retina tomograph (HRT) and scanning laser polarimetry (GDx) with photographic evaluation of the optic nerve head (ONH) and retinal nerve fiber layer (RNFL) in the application of the Finnish Evidence-Based Guideline for Open-Angle Glaucoma. Methods A total of 41 control participants and 312 patients referred for glaucoma evaluation were included in the study. All the participants underwent ophthalmic evaluation, ONH stereophotography, monochromatic RNFL photography, HRT, optical coherence tomography, and GDx evaluation. Participants were classified on the basis of stereophotographic or imaging device results based by applying the Finnish Guideline.Results Agreement between the stereophotographic evaluation and that on the basis of the imaging devices was 52.9%. Classification of patients with similar management advice on the basis of these evaluations had 56.4% agreement. The specificity of the Finnish guideline for detecting normal patients was 78% (stereophotography) and 83% (imaging devices). Optic disc size interfered with the diagnosis in patients evaluated using the HRT3 glaucoma probability score. Structural changes were more frequently detected before functional changes. Conclusion The Finnish Evidence-Based Guideline for Open-Angle Glaucoma is useful for classifying normal participants and patients with suspected glaucoma or glaucoma through either conventional stereophotographic evaluation of the neuroretinal structures or with the new imaging devices.

show abstract

The Finnish evidence‐based guideline for open‐angle glaucoma

Cited by 84 publications

References 199 publications

Association of LOXL1 gene with Finnish exfoliation syndrome patients

Association of LOXL1 gene with Finnish exfoliation syndrome patients

The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation

Performance of GDx and HRT in the Finnish Evidence-Based Guideline for Open-Angle Glaucoma

Contact Info

Product

Resources

About