The Finite Partial Fitted Journal Bearing

Disposition of chloroquine in man after single intravenous and oral doses.

“…As hearing impairment is a reported adverse effect of chloroquine (Dwivedi & Mehra, 1978: Hart & Naunton, 1976 audiometry was performed on all subjects. Pure tone audiometry in frequencies above the conventional test range has been claimed to be useful for early detection of hearing impairment induced by drugs (Jacobson et al, 1969). We applied a method for high frequency audiometry (Anggard et al, 1976) together with routine audiometry both before the start of the experiment, 2-3 h after each drug intake and usually 14 days later.…”

The bulk of endogenously produced IgG2a is eliminated from the serum of adult C57BL/6 mice with a half‐life of 6–8 days

“…Another way of assaying for the presence of allotype-specific antibodies in suppressed animals is to follow the decay of a mAb of the Iglb allotype injected into these mice and to compare its rate with that seen in control animals [8]. If suppressed animals are indeed producing anti-allotypic antibodies in amounts high enough to clear existing Iglb molecules from the serum, then the decay of Iglb antibodies is expected to be faster in suppressed than in control animals.…”

Chemistry and Pharmacology of Homologs of 6-Acetyl- and 3,6-Diacetylmorphine

“…As seen in Table 1, the 3,6-diformyl (11), 3,6-dipropanoyl (III), and 6-propanoyl (VI) derivatives were comparable to heroin (I) and 6acetylmorphine (IV) in analgesic potency and were three to four times as potent as morphine (6,7). 3-Acetylmorphine (VII) sulfamate (4) was nearly identical in potency to morphine.…”

“…It was dissolved in acetone-ether (3:l) and treated (to pH 4-5) with hydrogen chloride gas to give (ice cooling) 2.2 g of VI hydrochloride, which was dissolved in 140 ml of boiling acetone. The solution was concentrated to 45-50 ml NCH, (6,7). Numbers in parentheses are the 95% S E limits, as obtained by probit anal sis.…”