The multi-critical fixed points of O(N ) symmetric models cease to exist in the N → ∞ limit, but the mechanism regulating their annihilation still presents several enigmatic aspects. Here, we explore the evolution of high-order multi-critical points in the (d, N ) plane and uncover a complex mosaics for their asymptotic behaviour at large N . This picture is confirmed by various RG approaches and constitutes a fundamental step towards the full comprehension of critical behaviour in O(N ) field theories.