The Findings of Electrocardiography in Patients with Cardiac Amyloidosis

Cheng, Zhongwei; Zhu, Kongbo; Tian, Zhuang; Zhao, Dachun; Cui, Quancai; Fang, Quan

doi:10.1111/anec.12018

Cited by 53 publications

(52 citation statements)

References 12 publications

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“…A QS pattern in at least two precordial chest leads ("a pseudo-infarct pattern") and an inversion or depression of the T or ST section in the lateral chest leads can be seen in some patients [35][36][37][38][39] . The Holter ECG shows episodes of ventricular and supraventricular arrhythmia in a large number of asymptomatic patients.…”

Section: Electrocardiographymentioning

confidence: 99%

“…However, echocardiography cannot confirm diagnosis in isolation and is also unable to distinguish between various types of amyloidosis. A finding typical for infiltrative affection of the myocardium is end-diastolic thickness of the interventricular septum or left ventricular wall > 12 mm 35 . The use of the term "hypertrophy" is, in this case, incorrect, as the condition is not caused by the hypertrophy of cardiomyocytes, but by amyloid deposition.…”

Section: Echocardiographymentioning

confidence: 99%

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Amyloid cardiomyopathy

Karafiátová¹,

Pika²

2017

BIOMED PAP

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Section: Electrocardiographymentioning

confidence: 99%

Section: Echocardiographymentioning

confidence: 99%

Amyloid cardiomyopathy

Karafiátová¹,

Pika²

2017

BIOMED PAP

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“…However, this is thought to be the result of signficant under diagnosis and as improved non-invasive diagnostic approaches arise, this number is likely to increase [3]. In one recent analysis, ATTRwt occurs in greater than 25% of individuals at autopsy but the clinical significance of this finding remains unclear [4,5]. In an often cited but likely regionally, ethnic diversity limited survey, the age-adjusted incidence of AL amyloidosis is estimated to be beetween 5.1 and 12.8 per million person years [6].…”

Section: Epidemiologymentioning

confidence: 99%

“…As the heart becomes progressively larger and as the amyloid deposits into the heart's conduction system, patients are prone to arrythmias, especially atrial fibrillation [1,5]. Sudden cardiac death, often from ventricular and PEA rhythms, have also been associated [3].…”

Section: Epidemiologymentioning

confidence: 99%

“…When both were present, there was a high specificity and positive predictive value for cardiac amyloidosis, of 98% and 96% respectively. Unfortunately, this combination also proved to be very insensitive, with a sensitivity of only 28% [5,6]. Not surprisingly, those diagnosed with cardiac amyloidosis via autopsy versus those diagnosed when alive, showed a lower percentage of low voltage ECGs (17.65% versus 66.67% respectively) [7].…”

Section: Diagnostic Evaluationmentioning

confidence: 99%

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Cardiac amyloidosis: a case review series

2015

J Integr Cardiol

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Amyloidosis includes a spectrum of diseases that involve the deposition of misfolded proteins in various tissues throughout the body. There are many different proteins known to cause amyloidosis and the etiology of the amyloid subtype determines where the abnormal proteins deposit. AL, ATTRwt (formerly senile systemic amyloidosis), and ATTRm (formerly familial amyloidosis) are the most common amyloid subtypes that infiltrate cardiac tissue, resulting in a restrictive cardiomyopathy. In this series we report one case of each cardiac amyloidosis subtype, AL, ATTRwt, and ATTRm, that presented to Harbor-UCLA Medical Center between 2012-2013. All three patients had biopsies confirming cardiac amyloidosis as well as a cardiac MRI. Unfortunately, two of the three patients with cardiac amyloidosis passed away from PEA arrest illustrating the high mortality rate for this disease process. Since early diagnosis and treatment has shown improved median survival rates, we aim to review the diagnostic evaluation, treatment approaches, and prognosis for AL, ATTRwt, and ATTRm cardiac amyloidosis.

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Expert consensus on the monitoring of transthyretin amyloid cardiomyopathy

García‐Pavía

Bengel

Brito

et al. 2021

European J of Heart Fail

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Transthyretin amyloid cardiomyopathy (ATTR‐CM) is a life‐threatening condition with a heterogeneous clinical presentation. The recent availability of treatment for ATTR‐CM has stimulated increased awareness of the disease and patient identification. Stratification of patients with ATTR‐CM is critical for optimal management and treatment; however, monitoring disease progression is challenging and currently lacks best‐practice guidance. In this report, experts with experience in treating amyloidosis and ATTR‐CM developed consensus recommendations for monitoring the course of patients with ATTR‐CM and proposed meaningful thresholds and frequency for specific parameters. A set of 11 measurable features across three separate domains were evaluated: (i) clinical and functional endpoints, (ii) biomarkers and laboratory markers, and (iii) imaging and electrocardiographic parameters. Experts recommended that one marker from each of the three domains provides the minimum requirements for assessing disease progression. Assessment of cardiac disease status should be part of a multiparametric evaluation in which progression, stability or improvement of other involved systems in transthyretin amyloidosis should also be considered. Additional data from placebo arms of clinical trials and future studies assessing ATTR‐CM will help to elucidate, refine and define these and other measurements.

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The Findings of Electrocardiography in Patients with Cardiac Amyloidosis

Cited by 53 publications

References 12 publications

Amyloid cardiomyopathy

Amyloid cardiomyopathy

Cardiac amyloidosis: a case review series

Expert consensus on the monitoring of transthyretin amyloid cardiomyopathy

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