Abstract:The confirmation of the Intracellular Lactate Shuttle proposed by Brooks and colleagues in 1998 revolutionized the way lactate metabolism was studied in the field of exercise physiology, nutrition, metabolism, and medicine. Previous investigations identified the structure of the mitochondrial Lactate Oxidation Complex (mLOC) which includes MCT1, LDH, COX4, and CD147. While the predominant view in research and textbooks was that pyruvate was imported into the mitochondria to be oxidized it wasn’t until 2009 tha… Show more
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